Description and phylogenetic relationships of a new species of treefrog of the Dendropsophus leucophyllatus group (Anura: Hylidae) from the Amazon basin of Colombia and with an exceptional color pattern

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Report on the Meeting of delegates from CDCC countries attending the Regional Meeting of Latin America and the Caribbean Preparatory to the World Conference to Review and Appraise the Achievements of the United Nations Decade for Women: Equality, Development and Peace = Informe de la Reunión de delegados de los países del CDCC que participaron en la Reunión Regional de América Latina y el Caribe Preparatoria de la Conferencia Mundial para el Examen y Evaluación de los Logros del Decenio de las Naciones Unidas para la Mujer: Igualdad, Desarrollo y Paz

Informa sobre la reunion realizada con el objetivo de intercambiar informacion y buscar una posicion comun del Caribe en los temas a considerar en la Reunion Regional: problemas y logros alcanzados en la region en la implementacion de las metas y objetivos del decenio de las NU para la mujer, estrategia para el ano 2000.

Crecimiento y distribución de la población: su relación con el desarrollo y el medio ambiente = Population growth and distribution: their relations to development and the environment

Incluye Bibliografía

Actividades realizadas por la Comisión Económica para América Latina y el Caribe (CEPAL) para el fomento de la cooperación entre países y regiones en desarrollo (agosto de 1983 a julio de 1984) = Activities carried out by the Economic Commission for Latin America and the Caribbean (ECLAC) to promote co-operation among developing countries and regions (August 1983 to July 1984)

Resena las actividades de promocion de la cooperacion tecnica y economica entre paises en desarrollo realizadas por CEPAL en los planos regional e interregional, destacando los aportes hechos a las reuniones tecnicas convocadas por el Comite de Seguimiento y Coordinacion en el bienio 1983-1984.

Guía revisada para la cooperación técnica entre países en desarrollo (CTPD): oferta y directorio de instituciones = Revised guide to technical co-operation among developing countries (TCDC): supply and directory of institutions

Publicación bilingüe

Barreras que imponen los Estados Unidos a las exportaciones procedentes de América Latina y el Caribe 1992 = US barriers to Latin American and Caribbean exports 1992

Incluye Bibliografía

Comentarios al Capítulo 21 de la Agenda 21 Asuntos relativos al manejo ambientalmente adecuado de los residuos sólidos y de las aguas servidas" = Comments to Chapter 21 of Agenda 21 "Environmentally sound management of solid wastes and sewage-related issues""

Incluye Bibliografía

Barreras que imponen los Estados Unidos a las exportaciones procedentes de América Latina y el Caribe 1994 = US barriers to Latin American and Caribbean exports 1994

Incluye Bibliografía

Actividades de organismos de América Latina y el Caribe en relación a la utilización del espacio ultraterrestre con fines pacíficos: una base para fomentar la cooperación horizontal = Activities of Latin American and Caribbean organizations relating to the peaceful uses of outer space: a basis for developing horizontal co-operation

Incluye Bibliografía

A utilização do Resource Description and Access (RDA) na criação de registros de autoridade para pessoas, famílias e entidades coletivas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Down-regulation of ANAPC13 and CLTCL1: Early Events in the Progression of Preinvasive Ductal Carcinoma of the Breast

Alterations in the gene expression profile in epithelial cells during breast ductal carcinoma (DC) progression have been shown to occur mainly between pure ductal carcinoma in situ (DCIS) to the in situ component of a lesion with coexisting invasive ductal carcinoma (DCIS-IDC) implying that the molecular program for invasion is already established in the preinvasive lesion. For assessing early molecular alterations in epithelial cells that trigger tumorigenesis and testing them as prognostic markers for breast ductal carcinoma progression, we analyzed, by reverse transcription-quantitative polymerase chain reaction, eight genes previously identified as differentially expressed between epithelial tumor cells populations captured from preinvasive lesions with distinct malignant potential, pure DCIS and the in situ component of DCIS-IDC. ANAPC13 and CLTCL1 down-regulation revealed to be early events of DC progression that anticipated the invasiveness manifestation. Further down-regulation of ANAPC13 also occurred after invasion appearance and the presence of the protein in invasive tumor samples was associated with higher rates of overall and disease-free survival in breast cancer patients. Furthermore, tumors with low levels of ANAPC13 displayed increased copy number alterations, with significant gains at 1q (1q23.1-1q32.1), 8q, and 17q (17q24.2), regions that display common imbalances in breast tumors, suggesting that down-regulation of ANAPC13 contributes to genomic instability in this disease.

Development of an integrative cessation program for co-smokers of cigarettes and cannabis: demand analysis, program description, and acceptability

Abstract Background Tobacco and cannabis use are strongly interrelated, but current national and international cessation programs typically focus on one substance, and address the other substance either only marginally or not at all. This study aimed to identify the demand for, and describe the development and content of, the first integrative group cessation program for co-smokers of cigarettes and cannabis. Methods First, a preliminary study using expert interviews, user focus groups with (ex-)smokers, and an online survey was conducted to investigate the demand for, and potential content of, an integrative smoking cessation program (ISCP) for tobacco and cannabis co-smokers. This study revealed that both experts and co-smokers considered an ISCP to be useful but expected only modest levels of readiness for participation.Based on the findings of the preliminary study, an interdisciplinary expert team developed a course concept and a recruitment strategy. The developed group cessation program is based on current treatment techniques (such as motivational interviewing, cognitive behavioural therapy, and self-control training) and structured into six course sessions.The program was evaluated regarding its acceptability among participants and course instructors. Results Both the participants and course instructors evaluated the course positively. Participants and instructors especially appreciated the group discussions and the modules that were aimed at developing personal strategies that could be applied during simultaneous cessation of tobacco and cannabis, such as dealing with craving, withdrawal, and high-risk situations. Conclusions There is a clear demand for a double cessation program for co-users of cigarettes and cannabis, and the first group cessation program tailored for these users has been developed and evaluated for acceptability. In the near future, the feasibility of the program will be evaluated. Trial registration Current Controlled Trials ISRCTN15248397

Social anxiety and negative early life events in university students

INTRODUCTION: There is substantial evidence regarding the impact of negative life events during childhood on the aetiology of psychiatric disorders. We examined the association between negative early life events and social anxiety in a sample of 571 Spanish University students. METHODS: In a cross-sectional survey conducted in 2007, we collected data through a semistructured questionnaire of sociodemographic variables, personal and family psychiatric history, and substance abuse. We assessed the five early negative life events: (i) the loss of someone close, (ii) emotional abuse, (iii) physical abuse, (iv) family violence, and (v) sexual abuse. All participants completed the Liebowitz Social Anxiety Scale. RESULTS: Mean (SD) age was 21 (4.5), 75% female, LSAS score was 40 (DP = 22), 14.2% had a psychiatric family history and 50.6% had negative life events during childhood. Linear regression analyses, after controlling for age, gender, and family psychiatric history, showed a positive association between family violence and social score (p = 0.03). None of the remaining stressors produced a significant increase in LSAS score (p > 0.05). CONCLUSION: University students with high levels of social anxiety presented higher prevalence of negative early life events. Thus, childhood family violence could be a risk factor for social anxiety in such a population.