Iowa Spirits Price Book, November 2014,

Iowa Spirits Price Book is produced monthly details of the current prices of liquors in Iowa. Formerly titled Iowa Liquor Quarterly Spirits Price Book.

Iowa Spirits Price Book, December 2014,

Iowa Spirits Price Book is produced monthly details of the current prices of liquors in Iowa. Formerly titled Iowa Liquor Quarterly Spirits Price Book.

A fresh look at interferon-alpha signaling and treatment outcomes in chronic hepatitis C.

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The current standard therapy for chronic hepatitis C (CHC) consists of a combination of pegylated IFN alpha (pegIFNalpha) and ribavirin. It achieves a sustained viral clearance in only 50-60% of patients. To learn more about molecular mechanisms underlying treatment failure, we investigated IFN-induced signaling in paired liver biopsies collected from CHC patients before and after administration of pegIFNalpha. In patients with a rapid virological response to treatment, pegIFNalpha induced a strong up-regulation of IFN-stimulated genes (ISGs). As shown previously, nonresponders had high expression levels of ISGs before therapy. Analysis of posttreatment biopsies of these patients revealed that pegIFNalpha did not induce expression of ISGs above the pretreatment levels. In accordance with ISG expression data, phosphorylation, DNA binding, and nuclear localization of STAT1 indicated that the IFN signaling pathway in nonresponsive patients is preactivated and refractory to further stimulation. Some features characteristic of nonresponders were more accentuated in patients infected with HCV genotypes 1 and 4 compared with genotypes 2 and 3, providing a possible explanation for the poor response of the former group to therapy. Taken together with previous findings, our data support the concept that activation of the endogenous IFN system in CHC not only is ineffective in clearing the infection but also may impede the response to therapy, most likely by inducing a refractory state of the IFN signaling pathway.

ABD Promos, January 2015, Vol. 15, no. 1

The ABD Promos Newsletter is produced monthly and details Division announcements, holiday schedules, broker promotions and a newly listed codes clip out section.

Iowa Spirits Price Book, January 2015

Iowa Spirits Price Book is produced monthly details of the current prices of liquors in Iowa. Formerly titled Iowa Liquor Quarterly Spirits Price Book.

Capitol interior.

Audio files collected and compiled from the Iowa State Capitol grounds, monuments and memorials and building interior audio and video tour. The 18 areas featured and described correspond to stops on the Capitol visitor tours conducted by Legislative Services Agency guides

Iowa Spirits Price Book, February 2015

Iowa Spirits Price Book is produced monthly details of the current prices of liquors in Iowa. Formerly titled Iowa Liquor Quarterly Spirits Price Book.

ABD Promos, February 2015, Vol. 15, no. 2

The ABD Promos Newsletter is produced monthly and details Division announcements, holiday schedules, broker promotions and a newly listed codes clip out section.

Iowa Spirits Price Book, March 2015

Iowa Spirits Price Book is produced monthly details of the current prices of liquors in Iowa. Formerly titled Iowa Liquor Quarterly Spirits Price Book.

ABD Promos, March 2015, Vol. 15, no. 3

The ABD Promos Newsletter is produced monthly and details Division announcements, holiday schedules, broker promotions and a newly listed codes clip out section.

ABD Promos, April 2015, Vol. 15, no. 4

The ABD Promos Newsletter is produced monthly and details Division announcements, holiday schedules, broker promotions and a newly listed codes clip out section.

Iowa Spirits Price Book, April 2015

Iowa Spirits Price Book is produced monthly details of the current prices of liquors in Iowa. Formerly titled Iowa Liquor Quarterly Spirits Price Book.

Issue review : Nonresident deer hunting.

This issue review provides an overview of nonresidential deer-hunting licenses in Iowa.

Iowa : a picture of excellence, 1983

This brochure contains numerous picturesque photos and written descriptions of Iowa with the intent of inviting the film industry to do film production in Iowa.

Iowa Racing & Gaming Commission Annual Report 2013

The Annual Report of the Iowa Racing and Gaming Commission is committed to maintaining a vibrant racing and gaming industry that provides economic growth and development for the State of Iowa while continuing to promote responsible gaming.