Impacto do polimorfismo gen��tico do polipept��deo transportador de ��nions org��nicos 1B1 (OATP1B1) na efic��cia e seguran��a da atorvastatina

A atorvastatina, amplamente utilizada no tratamento de dislipidemias, �� f��rmaco inibidor da enzima 3-hidroxi-3-metilglutaril coenzima A redutase (HMG-CoA) redutase que atua na etapa limitante da s��ntese do colesterol nas c��lulas hep��ticas. O transporte hepatocelular da atorvastatina �� mediado principalmente pelo polipept��deo transportador de ��nions org��nicos (OATP) 1B1, o qual �� altamente polim��rfico geneticamente e est�� sujeito a intera����o com outros f��rmacos usados na cl��nica. O presente estudo teve como objetivo revisar a literatura cient��fica baseada em estudos cl��nicos, in vitro e experimentais a fim de avaliar o impacto de polimorfismos gen��ticos de OATP1B1 na disposi����o cin��tica, efic��cia e toxicidade da atorvastatina. Os estudos cl��nicos demonstram que o polimorfismo c.521T>C, presente nos alelos SLCO1B1 *5 e *15, resulta em altera����o funcional da atividade transportadora, sendo que indiv��duos homozigotos para o alelo raro C, apresentam maiores concentra����es plasm��ticas de atorvastatina e seus metab��litos ativos 2-hidroxiatorvastatina e 4- hidroxiatorvastatina. Entretanto, o aumento na concentra����o plasm��tica da atorvastatina e seus metab��litos ativos em indiv��duos c.521 CC parece n��o ser acompanhado de redu����o na concentra����o dos mesmos no s��tio alvo, tendo em vista que n��o foram encontradas diferen��as significativas na redu����o da LDL-C ou colesterol total quando comparados aos indiv��duos homozigotos para o alelo selvagem. O alelo SLCO1B1*15 mostrou-se significativamente associado a miopatia induzida pela atorvastatina, apesar do pequeno n��mero de pacientes investigados. Estudos in vitro em c��lulas expressando OATP1B1 s��o necess��rios a fim de investigar o impacto do polimorfismo c.521T>C na concentra����o de atorvastatina nos hepat��citos. Sugere-se ainda que estudos cl��nicos sejam conduzidos a fim de avaliar se a redu����o da dose de...

An��lise de SNPs do DNA mitocondrial em indiv��duos residentes no estado do Esp��rito Santo para aplica����o na Identifica����o Humana

P��s-gradua����o em Biotecnologia - IQ

As tem��ticas de pesquisa da geografia agr��ria nas disserta����es e teses dos programas de p��s-gradua����o em geografia na regi��o sudeste

Conselho Nacional de Desenvolvimento Cient��fico e Tecnol��gico (CNPq)

O casamento entre o ensino religioso e as teses p��s-modernas

This paper aims to base the thesis that the varied currents of the post-modern thought, in so far as have recourse to relativism to a greater or lesser degree, contribute to the legitimation of the religious education in public schools and, in a broader aspect, the religion in the public spaces. The methodological resource used to demonstrate the link between post-modern thought and religious education is the analysis at the historical and dialectical materialism perspective of publications produced to increase teachers on this discipline that is, in compliance with the Constitution, optional for students and mandatory for public elementary schools. The subject of this analysis is the learning content and has as prime concern to highlight the discourse of legitimation recurrent in authors when it is explicit in itself and explicit when it does not. The ���religious education in public schools��� as object of study allows us to understand the relationship between the post-modern thought, with its hegemony space within the human sciences and contextualized in the neoliberal economic environment, and the ���learning to learn��� pedagogies currently hegemonic in the educational landscape. We intend to contribute to the legal debate on laity, the philosophical debate on post-modernism and especially to the debate on the pedagogical theories in the educational fundaments.

A formula����o de uma corrente urban��stica: uma (re)visita ��s teses de Anhaia Mello para S��o Paulo

The present article aims to elaborate an objective analytical panel, initially from the 1920- 1930 when Luiz Ign��cio Romeiro de Anhaia Mello, cathedratic in the urban question, started to quote a series of authors and American plans as references to their reflections, mainly when the point was the verticalization or not at S��o Paulo City. From a broad bibliographic research with the systematization of the register from the debate between Anhaia Mello, this article intends to point out how the transposition of the urbanistic conceptions to the academic environment happened and, at the same time, the legal normatization of the S��o Paulo City that resulted in the creation of a draft of the regulations for use and occupation of the soil. The systematizations and analysis were based in a broad reading of the bibliography and documental sources that refer to the proposed theme. The books of the library of FAU-USP, specifically the one from SAGMACS ��� Sociedade de An��lises Gr��ficas e Mecanogr��ficas Aplicadas aos Complexos Sociais ( Society of Graphical Mechanical-Graphic Analysis Applied to Social Complexes) -, aiming to select papers and the collection of Anhaia Mello��s family, so that a reconstruction of the intellectual and professional journey of the Urbanism Professor. The systematization of the collected data and posterior comparison with the bibliographical study was fundamental for the reconstruction of the reflection of Anhaia Mello about the ways of the urban streets and roads at Sao Paulo City should be lead to on the middle of the XX century having as a guideline the debate between Anhaia Mello ��� very common on the 1950s for less important countries when dealing with the organization of the size of industrial metropolis. It was possible to identify the crystallization of one urbanistic proposal for the city: the from Anhaia Mello, that bet on the reversion of the metropolitan cycle by stopping the urban growth by the application of the theoretical conception of the garden city.

Achados cl��nicos, gen��ticos e microbiol��gicos de uma fam��lia com periodontite agressiva de Macei��

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Varia����o genética e desempenho de prog��nies de Pinus caribaea var. hondurensis para produ����o de madeira e resina

P��s-gradua����o em Agronomia - FEIS

An��lise da frequencia do polimorfismo rs12979860 C/T no gene IL28B em pacientes acometidos por c��ncer g��strico

P��s-gradua����o em Pesquisa e Desenvolvimento (Biotecnologia M��dica) - FMB

Estrutura genética de popula����es de Rhizoctonia oryzae-sativae do arroz em S��o Paulo, Brasil, e em meta, Col��mbia, e potencial adaptativo do pat��geno �� Urochloa spp

P��s-gradua����o em Agronomia - FEIS

Contribui����es da epistemologia genética para a constru����o do conhecimento na educa����o infantil

The kindergarten has as main objective the development of the child from zero to five years in their physical, emotional, cognitive and social domains. This is also the goal of the Centers for Children Living from the Universidade Estadual Paulista (UNESP) that caters to children of teachers, technical and administrative staff and students. In this work we report some of the action of the Technical Commission of the CCIs with reflections on the construction of children's knowledge through observations of the CCIs in different campuses of Unesp, conducted through technical visits. As a theoretical contribution we adopt the Genetic Epistemology of Jean Piaget. Partial results show that, although there are efforts to understand and assist the process of constructing knowledge of children, many challenges remain to be overcome in the realization of an excellent service to children.

Variabilidade do padr��o de esterases e atividade da glutationa S-transferase em linhagens geogr��ficas de Drosophila melanogaster e D. simulans resistentes e suscet��veis ao inseticida DDT

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

Estudo intra e interpopulacional de Pachycoris Torridus (Scopoli, 1772) (Heteroptera: Scutelleridae)

P��s-gradua����o em Genética - IBILCE

An��lise de Altera����es Cromoss��micas, Muta����es no ��xon 1 e do Padr��o de Metila����o da Regi��o Promotora do Gene FOXO3 em S��ndrome Mielodispl��sica

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

Associa����o genética de caracter��sticas de qualidade de carne e precocidade sexual em animais Nelore (Bos indicus)

P��s-gradua����o em Genética e Melhoramento Animal - FCAV

Diversidade cl��nica, epidemiol��gica e Genética do Mycobacterium tuberculosis na regi��o Noroeste paulista

P��s-gradua����o em Genética - IBILCE