Igneous garnet and amphibole fractionation in the roots of island arcs: experimental constraints on andesitic liquids

To evaluate the role of garnet and amphibole fractionation at conditions relevant for the crystallization of magmas in the roots of island arcs, a series of experiments were performed on a synthetic andesite at conditions ranging from 0.8 to 1.2 GPa, 800-1,000 degrees C and variable H2O contents. At water undersaturated conditions and fO(2) established around QFM, garnet has a wide stability field. At 1.2 GPa garnet ? amphibole are the high-temperature liquidus phases followed by plagioclase at lower temperature. Clinopyroxene reaches its maximal stability at H2O-contents <= 9 wt% at 950 degrees C and is replaced by amphibole at lower temperature. The slopes of the plagioclase-in boundaries are moderately negative in T-XH2O space. At 0.8 GPa, garnet is stable at magmatic H2O contents exceeding 8 wt% and is replaced by spinel at decreasing dissolved H2O. The liquids formed by crystallization evolve through continuous silica increase from andesite to dacite and rhyolite for the 1.2 GPa series, but show substantial enrichment in FeO/MgO for the 0.8 GPa series related to the contrasting roles of garnet and amphibole in fractionating Fe-Mg in derivative liquids. Our experiments indicate that the stability of igneous garnet increases with increasing dissolved H2O in silicate liquids and is thus likely to affect trace element compositions of H2O-rich derivative arc volcanic rocks by fractionation. Garnet-controlled trace element ratios cannot be used as a proxy

Proyecto de ejecución para las obras de concesión de dominio público para la reforma y adecuación de la central térmica y de la red de saneamiento en un hospital de 350 camas

El Hospital Punta de Europa en Algeciras (Cádiz), centro sanitario del Servicio Andaluz de Salud, desea optimizar la gestión de sus instalaciones de generación de energía térmica (vapor, agua caliente sanitaria y agua caliente de calefacción) y adecuarlas a la normativa vigente así como la sustitución de bajantes del edificio, para lo cual sacará a concurso público la licitación para la concesión de dominio público de dichas instalaciones. Para definir el alcance y condiciones de la citada concesión, el Hospital Punta de Europa (Algeciras) del Servicio Andaluz de Salud ha solicitado a Pedro Alonso Martín el estudio para la reforma y adecuación de las instalaciones productoras de energía térmica del citado Hospital. El objetivo principal de este trabajo es hacer un estudio, propuesta y valoración de las actuaciones necesarias para la reforma y mejora de la explotación de las instalaciones generadoras de energía térmica y de la red saneamiento interior del Hospital Punta de Europa de Algeciras (Cádiz). Las actuales instalaciones de generación térmica consumidoras de energía del hospital dentro del alcance de este Proyecto son: Generación de vapor (lavandería y esterilización). Producción de agua caliente sanitaria (ACS). Producción de agua caliente de calefacción. La mayoría de los equipos productores de energía datan del año 1975, por lo que en la mayoría de los casos se ha cumplido su plazo de amortización y periodo de vida útil. Se hace necesaria la instalación de gas natural, debido a que se tendrá que abastecer a todas las calderas de la central térmica. El diseño del sistema de producción de agua caliente sanitaria garantiza el máximo confort y economía del usuario, compatible con el máximo ahorro energético y la protección del medio ambiente, cubriendo las necesidades de agua caliente sanitaria mediante la combinación de un sistema de calderas a gas con los colectores solares.

Parametrización de CMS para análisis sanguíneos

El proyecto ha consistido en la implantación de una web para DBSS, con doble finalidad: una pública de información general sobre la misma y otra privada para la automatización de la entrada de datos de análisis de sangre y su posterior consulta por parte del paciente. Se han seleccionado las tecnologías adecuadas tanto para el diseño de la web como de las bases de datos asociadas. Se han programado la web y las bases de datos con éxito y se ha realizado la implementación del sistema, realizándose pruebas de funcionamiento internas y externas con éxito, comprobándose la bondad de la aplicación.

International Olympic Committee consensus statement on thermoregulatory and altitude challenges for high-level athletes.

Challenging environmental conditions, including heat and humidity, cold, and altitude, pose particular risks to the health of Olympic and other high-level athletes. As a further commitment to athlete safety, the International Olympic Committee (IOC) Medical Commission convened a panel of experts to review the scientific evidence base, reach consensus, and underscore practical safety guidelines and new research priorities regarding the unique environmental challenges Olympic and other international-level athletes face. For non-aquatic events, external thermal load is dependent on ambient temperature, humidity, wind speed and solar radiation, while clothing and protective gear can measurably increase thermal strain and prompt premature fatigue. In swimmers, body heat loss is the direct result of convection at a rate that is proportional to the effective water velocity around the swimmer and the temperature difference between the skin and the water. Other cold exposure and conditions, such as during Alpine skiing, biathlon and other sliding sports, facilitate body heat transfer to the environment, potentially leading to hypothermia and/or frostbite; although metabolic heat production during these activities usually increases well above the rate of body heat loss, and protective clothing and limited exposure time in certain events reduces these clinical risks as well. Most athletic events are held at altitudes that pose little to no health risks; and training exposures are typically brief and well-tolerated. While these and other environment-related threats to performance and safety can be lessened or averted by implementing a variety of individual and event preventative measures, more research and evidence-based guidelines and recommendations are needed. In the mean time, the IOC Medical Commission and International Sport Federations have implemented new guidelines and taken additional steps to mitigate risk even further.

El Brasil de los populismos: de la construcción de la identidad nacional a la supuesta democracia racial

El autor estudia la creación de una identidad nacional en Brasil durante los siglos XIX y XX, incidiendo en los intereses de las élites gobernantes para formular un determinado discurso integrador de lo indígena y lo africano. / L'autor estudia la creació d'una identitat nacional al Brasil durant els segles XIX i XX, incidint en els interessos de les èlits governants per formular un determinat discurs integrador d'allò indígena i allò africà. / The author studies the creation of a national identity in Brazil during the 19th and 20th century, focus on the elites rulers interests to formulate a determined integrative speech of the ¿native¿ and the ¿African¿.

Tiempos afroindigenas en la amazonia brasileña. Primera mitad del siglo XIX.

La Amazonia brasileña durante la primera mitad del siglo XIX estuvo marcada por una extraordinaria inestabilidad político-militar. Su adhesión tardía a la independencia de Brasil (1823), el debate sobre la esclavitud y la explosión de la Cabanagem fueron procesos que tuvieron como protagonistas no sólo a las elites políticas lusobrasileñas, sino también a diferentes grupos cimarrones e indígenas que actuaban desde amplios e intrincados espacios de frontera, atentos a las ideas revolucionarias que provenían del exterior y que jugaron un papel fundamental en la construcción de la especificidad del norte de Brasil.

Missatges autoreferencials dels actors del ritual de l'Id-al-ad·ha

L'article analitza la celebració de l'Id-al-ad·ha o "festa del sacrifici", ritual protagonitzat per la comunitat de musulmans el desè dia del mes de dhu-al-hijja. Es parteix d'exemples etnogràfics procedents del context de la diàspora musulmana al Tarragonès i de la societat emiral mauritana. El fenomen s'analitza des dels rols que els actors exerceixen en el ritual. L'argumentació vol subratllar la idea que tot ritual s'inscriu en un context social específic del qual n'és producte alhora que modulador, per mitjà del que Roy Rappaport anomena "missatges autoreferencials". Això no exclou l'existència d'un conjunt de denominadors comuns o "missatges canònics" entre les diverses pràctiques rituals referides.

Variabilidade espacial de atributos físicos de solo usada na identificação de classes pedológicas de microbacias na Amazônia meridional

A região noroeste do Estado de Mato Grosso compreende paisagens de grande complexidade para amostragem de solo. Isso ocorre devido à contínua atividade geomorfológica, que contribuiu para a existência de diferentes classes pedológicas em pequenas distâncias. O trabalho foi desenvolvido em Juruena (MT), com o objetivo de identificar as classes pedológicas em microbacias sob floresta não-perturbada, por meio do estudo da variabilidade espacial da textura (relação textural) e cor (índice de avermelhamento) do solo, considerando-se ainda a altitude da paisagem. A variabilidade espacial da textura e da cor do solo foi determinada em amostras de 185 pontos georreferenciados em malha sistemática regular com espaçamento de 20 x 20 m, abrangendo quatro microbacias. Usando profundidades de 0-20 e 40-60 cm, foi possível distinguir e mapear as principais classes de solo ocorrentes na área de estudo até o segundo nível categórico do Sistema Brasileiro de Classificação de Solos, associadas ao fator relevo da paisagem. Também foi estabelecida uma correspondência bastante satisfatória entre os intervalos do índice de avermelhamento do horizonte diagnóstico e as cores das classes de solo. As microbacias apresentaram as classes Plintossolos e Argissolos (com caráter plíntico) em altitudes inferiores a 280 m e Latossolos nas cotas superiores. Dessa forma, ficou evidenciada a possibilidade do uso da geoestatística para separar classes homogêneas de solo, além de estimar a precisão de mapeamento. Contudo, são indispensáveis o conhecimento pedológico e o trabalho posterior de campo para a aplicação e o ajuste dessa modelagem.

El camí a Europa: els serveis d'aprenentatge i recerca a les biblioteques de la UPC

The article shows how the library services of the Universitat Politècnica de Catalunya (UPC) manage change and explores the current opportunities available (university, electronic information, etc.) for converting the libraries into centres that actively support training and research at the university level. After providing information about the current university scenario, the article focuses on the road taken by the UPC libraries to overcome at both a conceptual and a practical level the major challenge of the millennium: transforming the traditional university library into a centre with resources for supporting academic teaching and research.

Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T Lymphocytes during cell polarization

During activation, T lymphocytes become motile cells, switching from a spherical to a polarized shape. Chemokines and other chemotactic cytokines induce lymphocyte polarization with the formation of a uropod in the rear pole, where the adhesion receptors intercellular adhesion molecule-1 (ICAM-1), ICAM-3, and CD44 redistribute. We have investigated membrane-cytoskeleton interactions that play a key role in the redistribution of adhesion receptors to the uropod. Immunofluorescence analysis showed that the ERM proteins radixin and moesin localized to the uropod of human T lymphoblasts treated with the chemokine RANTES (regulated on activation, normal T cell expressed, and secreted), a polarization-inducing agent; radixin colocalized with arrays of myosin II at the neck of the uropods, whereas moesin decorated the most distal part of the uropod and colocalized with ICAM-1, ICAM-3, and CD44 molecules. Two other cytoskeletal proteins, ß-actin and ¿-tubulin, clustered at the cell leading edge and uropod, respectively, of polarized lymphocytes. Biochemical analysis showed that moesin coimmunoprecipitates with ICAM-3 in T lymphoblasts stimulated with either RANTES or the polarization- inducing anti-ICAM-3 HP2/19 mAb, as well as in the constitutively polarized T cell line HSB-2. In addition, moesin is associated with CD44, but not with ICAM-1, in polarized T lymphocytes. A correlation between the degree of moesin-ICAM-3 interaction and cell polarization was found as determined by immunofluorescence and immunoprecipitation analysis done in parallel. The moesin-ICAM-3 interaction was specifically mediated by the cytoplasmic domain of ICAM-3 as revealed by precipitation of moesin with a GST fusion protein containing the ICAM-3 cytoplasmic tail from metabolically labeled Jurkat T cell lysates. The interaction of moesin with ICAM-3 was greatly diminished when RANTES-stimulated T lymphoblasts were pretreated with the myosin-disrupting drug butanedione monoxime, which prevents lymphocyte polarization. Altogether, these data indicate that moesin interacts with ICAM-3 and CD44 adhesion molecules in uropods of polarized T cells; these data also suggest that these interactions participate in the formation of links between membrane receptors and the cytoskeleton, thereby regulating morphological changes during cell locomotion.

MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration

Membrane organization into condensed domains or rafts provides molecular platforms for selective recruitment of proteins. Cell migration is a general process that requires spatiotemporal targeting of Rac1 to membrane rafts. The protein machinery responsible for making rafts competent to recruit Rac1 remains elusive. Some members of the MAL family of proteins are involved in specialized processes dependent on this type of membrane. Because condensed membrane domains are a general feature of the plasma membrane of all mammalian cells, we hypothesized that MAL family members with ubiquitous expression and plasma membrane distribution could be involved in the organization of membranes for cell migration. We show that myeloid-associated differentiation marker (MYADM), a protein with unique features within the MAL family, colocalizes with Rac1 in membrane protrusions at the cell surface and distributes in condensed membranes. MYADM knockdown (KD) cells had altered membrane condensation and showed deficient incorporation of Rac1 to membrane raft fractions and, similar to Rac1 KD cells, exhibited reduced cell spreading and migration. Results of rescue-of-function experiments by expression of MYADM or active Rac1L61 in cells knocked down for Rac1 or MYADM, respectively, are consistent with the idea that MYADM and Rac1 act on parallel pathways that lead to similar functional outcomes.

Reliure de : Bap. Platinae,... de Vitis ac gestis summorum pontificum ad sua usque tempora liber unus [cum authoris vita ex libro J. Trittemii "de Scriptoribus ecclesiasticis"]. Huic additae sunt vitae ac res gestae eorum qui interim fuere pontificum, a Paulo videlicet II, ad Julium hujus nominis III. Ejusdem item Platinae, de Falso et vero bono dialogi tres ; Contra amores I ; de Vera nobilitate I ; de Optimo cive II ; Panegyricus in Bessarionem,... Oratio ad Paulum II,... de bello Turcis inferendo. [-Panegyrici in Bap. Platinae parentalia.]

Numérisation partielle de reliure

Low noise pixel detectors based on gated geiger mode avalanche photodiodes

The gated operation is proposed as an effective method to reduce the noise in pixel detectors based on Geiger mode avalanche photodiodes. A prototype with the sensor and the front-end electronics monolithically integrated has been fabricated with a conventional HV-CMOS process. Experimental results demonstrate the increase of the dynamic range of the sensor by applying this technique.

Gated Geiger mode avalanche photodiode pixels with integrated readout electronics for low noise photon detection

Avalanche photodiodes operated in the Geiger mode offer a high intrinsic gain as well as an excellent timing accuracy. These qualities make the sensor specially suitable for those applications where detectors with high sensitivity and low timing uncertainty are required. Moreover, they are compatible with standard CMOS technologies, allowing sensor and front-end electronics integration within the pixel cell. However, the sensor suffers from high levels of intrinsic noise, which may lead to erroneous results and limit the range of detectable signals. They also increase the amount of data that has to be stored. In this work, we present a pixel based on a Geiger-mode avalanche photodiode operated in the gated mode to reduce the probability to detect noise counts interfering with photon arrival events. The readout circuit is based on a two grounds scheme to enable low reverse bias overvoltages and consequently lessen the dark count rate. Experimental characterization of the fabricated pixel with the HV-AMS 0.35µm standard technology is also presented in this article.