Sistema de Inscrição para Prova de Ingresso Online

Este trabalho visa apresentar o desenvolvimento de um Sistema de Inscrição Para a Prova de Ingresso Online, dando um especial enfoque à inscrição e selecção dos candidatos para a prova de ingresso na Uni-CV. A situação actual da gestão de inscrição para prova de ingresso era efectuada manualmente, sendo que isto causa alguns constrangimentos. Considera-se que deve primar para uma gestão mais eficiente. Neste sentido, define-se como objectivo o desenvolvimento desse Sistema de Inscrição para Prova de Ingresso Online na Uni-CV. Para o efeito, analisa-se neste trabalho o sistema actual numa perspectiva de concepção de uma aplicação que atenda as necessidades específicas e reais desta Instituição. Várias abordagens foram conceptualmente discutidas num referencial teórico para elaboração do sistema, tendo sido privilegiados os conhecimentos apreendidos durante a formação académica designadamente nas disciplinas Técnicas de Programação, Base de Dados, Sistemas de Informação, Desenvolvimento de Projectos Informáticos, Desenvolvimento avançado de aplicações internet, Planeamento e gestão de projectos, Projectos e Metodologias de Desenvolvimento de Sistemas de Informação. A análise do sistema e a geração de documentação da base de dados foram realizadas com os recursos das ferramentas de desenvolvimento. Para o desenvolvimento do sistema foram utilizados as linguagens de programação PHP, HTML, UML. Para a base de dados que elegeu-se o MySQL. Fundamentou-se essa opção, pelo facto de serem tecnologias modernas e que proporcionam ao sistema uma grande fiabilidade e também porque a Instituição utiliza-se as mesmas tecnologias, o que facilita as coisas.

Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.

Impairment of lung liquid absorption can lead to severe respiratory symptoms, such as those observed in pulmonary oedema. In the adult lung, liquid absorption is driven by cation transport through two pathways: a well-established amiloride-sensitive Na(+) channel (ENaC) and, more controversially, an amiloride-insensitive channel that may belong to the cyclic nucleotide-gated (CNG) channel family. Here, we show robust CNGA1 (but not CNGA2 or CNGA3) channel expression principally in rat alveolar type I cells; CNGA3 was expressed in ciliated airway epithelial cells. Using a rat in situ lung liquid clearance assay, CNG channel activation with 1 mM 8Br-cGMP resulted in an approximate 1.8-fold stimulation of lung liquid absorption. There was no stimulation by 8Br-cGMP when applied in the presence of either 100 μM L: -cis-diltiazem or 100 nM pseudechetoxin (PsTx), a specific inhibitor of CNGA1 channels. Channel specificity of PsTx and amiloride was confirmed by patch clamp experiments showing that CNGA1 channels in HEK 293 cells were not inhibited by 100 μM amiloride and that recombinant αβγ-ENaC were not inhibited by 100 nM PsTx. Importantly, 8Br-cGMP stimulated lung liquid absorption in situ, even in the presence of 50 μM amiloride. Furthermore, neither L: -cis-diltiazem nor PsTx affected the β(2)-adrenoceptor agonist-stimulated lung liquid absorption, but, as expected, amiloride completely ablated it. Thus, transport through alveolar CNGA1 channels, located in type I cells, underlies the amiloride-insensitive component of lung liquid reabsorption. Furthermore, our in situ data highlight the potential of CNGA1 as a novel therapeutic target for the treatment of diseases characterised by lung liquid overload.

BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.

B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.

Infancy Gospels. Stories and Identities

Even though the canonical Jesus' infancy stories have always provoked great interest in popular culture and in the arts, they have been neglected in research during the last decades due to the relatively late date of their redaction. Since the monograph by Raymond Brown, The Birth of the Messiah , the researchers working on this topic have not attempted to consider its historical impact. In this volume, an international team of scholars proposes firstly a reconsideration of the historical background of these stories in terms of early Jewish and Christian identity quests. Secondly, they deal with early Christian questions on Jesus' infancy and childhood through canonical and apocryphal Gospels including information from Patristic and documentary literature. On the theological level, this volume illustrates the impact that these apocryphal texts, recognized as "useful for the soul" (a phrase coined by François Bovon), have had on the Christian faith.