Análise da dinâmica do processo de reparo de alvéolos preenchidos com coágulo sanguineo e vidro bioativo (Perioglass®) em ratos não diabéticos, diabéticos controlados e não controlados: estudo histológico, histométrico e imunoistoquímico

Pós-graduação em Odontologia - FOA

Enxerto autógeno para aumento em espessura e ou altura do processo ósseo alveolar, transtornos de técnica cirúrgica, complicações e sobrevivência dos implantes

Pós-graduação em Odontologia - FOA

Avaliação da reação periodontal na técnica de colagem extra-alveolar de fraturas radiculares verticais simuladas: estudo histológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Reparação óssea após osteotomia com brocas de alta e baixa rotação e refrigeração líquida: estudo histológico comparativo entre tecido ósseo alveolar e extra-alveolar em suínos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito do L-Name na expressão de iNOS, MPO e na perda óssea alveolar em ratos diabéticos com periodontite experimental

Pós-graduação em Odontologia - FOAR

Avaliação microscópica da movimentação dentária induzida em dentes traumatizados: um estudo experimental em ratos

Pós-graduação em Odontologia - FOA

Estudo da influência de corticóides no processo inicial de osseointegração de implantes de titânio instalados em maxilas de ratos

Pós-graduação em Odontologia - FOA

Influência do estado diabético na doença periodontal induzida em ratos: análise metabólica, genética e radiográfica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Resonant properties, of modified triangular plasmonic nanoparticles with higher field concentration

In this paper, we present an analysis of the resonant response of modified triangular metallic nanoparticles with polynomial sides. The particles are illuminated by an incident plane wave and the method of moments is used to solve numerically the electromagnetic scattering problem. We investigate spectral response and near field distribution in function of the length and polynomial order of the nanoparticles. Our results show that in the analyzed wavelength range (0.5-1.8) µm these particles possess smaller number of resonances and their resonant wavelengths, near field enhancement and field confinement are higher than those of the conventional triangular particle with linear sides.

Therapeutic concentration of morphine reduces oxidative stress in glioma cell line

Morphine is a potent analgesic opioid used extensively for pain treatment. During the last decade, global consumption grew more than 4-fold. However, molecular mechanisms elicited by morphine are not totally understood. Thus, a growing literature indicates that there are additional actions to the analgesic effect. Previous studies about morphine and oxidative stress are controversial and used concentrations outside the range of clinical practice. Therefore, in this study, we hypothesized that a therapeutic concentration of morphine (1 μM) would show a protective effect in a traditional model of oxidative stress. We exposed the C6 glioma cell line to hydrogen peroxide (H₂O₂) and/or morphine for 24 h and evaluated cell viability, lipid peroxidation, and levels of sulfhydryl groups (an indicator of the redox state of the cell). Morphine did not prevent the decrease in cell viability provoked by H₂O₂) but partially prevented lipid peroxidation caused by 0.0025% H₂O₂) (a concentration allowing more than 90% cell viability). Interestingly, this opioid did not alter the increased levels of sulfhydryl groups produced by exposure to 0.0025% H₂O₂), opening the possibility that alternative molecular mechanisms (a direct scavenging activity or the inhibition of NAPDH oxidase) may explain the protective effect registered in the lipid peroxidation assay. Our results demonstrate, for the first time, that morphine in usual analgesic doses may contribute to minimizing oxidative stress in cells of glial origin. This study supports the importance of employing concentrations similar to those used in clinical practice for a better approximation between experimental models and the clinical setting.

Avaliação fotoelástica de overdentures mandibulares sobre implantes com três diferentes sistemas de retenção e prótese protocolo de Branemark

Pós-graduação em Odontologia - FOA

Intraspecific variability of Holostylis reniformis: concentration of lignans, as determined by maceration and supercritical fluid extraction (SFE-CO2), as a function of plant provenance and plant parts

Maceration and supercritical fluid extraction were used to prepare extracts from parts of plants (Holostylis reniformis) collected in two different regions of Brazil. ¹H NMR, HPLC-DAD-ESI/MS, HPLC-DAD, GC-MS, and chemometric techniques were used to analyse lignans in the extracts and showed that yields of SFE-CO2 were less than or equal to those of hexane maceration extracts. These analyses, in conjunction with the concentrations of aliphatic hydrocarbons, fatty acids and their methyl and ethyl derivatives in the extracts, also allowed the chemical composition of parts and provenance of the plant to be differentiated.

Análise através do método dos elementos finitos das tensões desenvolvidas no reborbo alveolar sob as próteses totais com três diferentes conceitos oclusais

Pós-graduação em Reabilitação Oral - FOAR

Histological analysis of the periodontal ligament and alveolar bone during dental movement in diabetic rats subjected to low-level laser therapy

Objective: The purpose of this research was to evaluate the histological changes of the periodontal ligament and alveolar bone during dental movement in diabetic rats subjected to low level laser therapy (LLLT).Methods: The movement of the upper molar was performed in 60 male Wistar rats divided into four groups (n = 15): CTR (control), DBT (diabetic), CTR/LT (irradiated control) and DBT/LT (irradiated diabetic). Diabetes was induced with alloxan (150 mg/kg, i.p.). LLLT was applied with GaAlAs laser at 780 nm (35 J/cm(2)). After 7, 13 and 19 days, the periodontal ligament and alveolar bone were histologically analyzed.Results: The mean of osteoblasts (p < 0.01) and blood vessels (p < 0.05) were significantly decreased in DBT compared with CTR at 7 days, whereas the mean of osteoclasts was lower at 7 (p < 0.001) and 13 days (p < 0.05). In DBT/LT, only the mean of osteoclasts was lower than in CTR (p < 0.05) at 7 days, but no difference was observed at 13 and 19 days (p > 0.05). The collagenization of the periodontal ligament was impaired in DBT, whereas DBT/LLT showed density/disposition of the collagen fibers similar to those observed in CTR.Conclusions: LLLT improved the periodontal ligament and alveolar bone remodeling activity in diabetic rats during dental movement. (C) 2014 Elsevier B.V. All rights reserved.