The North-South dimension of the environmental and cleaner technology industries

Includes bibliography

As TIC e o professor: uma reflexão sobre o potencial uso da TV digital no campo pedagógico

Pós-graduação em Televisão Digital: Informação e Conhecimento - FAAC

New technologies and methodologies for intervention to promote development

Includes bibliography

Electronic commerce, international trade and employment: review of the issues

Includes bibliography

O portal do professor e projetos de trabalho: uma proposta de construção de um ambiente de aprendizagem Matemática no ensino fundamental

Pós-graduação em Educação - FCT

Gestão estratégica de negócio e as tecnologias de informação: o caso do gerenciador financeiro do Banco do Brasil

Pós-graduação em Ciência da Informação - FFC

A tecnologia e a informação na construção de valores de responsabilidade social

Pós-graduação em Ciência da Informação - FFC

Os primeiros contatos de professores de línguas estrangeiras com a prática de Teletandem

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Investigando o processo ensino-aprendizagem de LE in-tandem: aprendizagem da língua francesa em contexto digital

Pós-graduação em Estudos Linguísticos - IBILCE

ICTs and information management (IM) in commercial agriculture: contributions from an evolutionary approach

Includes bibliography

The digital economy for structural change and equality

Includes bibliography.

Integralismo e ideologia autocrática chauvinista regressiva: crítica aos herdeiros do sigma

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise das práticas de E-GOV de municípios sulmineiros: estudos de casos múltiplos

Pós-graduação em Engenharia Mecânica - FEG

Tecnologias, mídias, criação e hipertextualidade na transformação da informação em conhecimento interativo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

GABA and glutamate transporters: new events and function in the vertebrate retina

The neural retina is a highly complex tissue composed of excitatory and inhibitory neurons and glial cells. Glutamate, the main excitatory neurotransmitter, mediates information transfer from photoreceptors, bipolar cells, and ganglion cells, whereas interneurons, mainly amacrine and horizontal cells, use γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter. In this review we place an emphasis on glutamate and GABA transporters as highly regulated molecules that play fundamental roles in neurotransmitter clearance, neurotransmitter release, and oxidative stress. We pharmacologically characterized glutamate transporters in chicken retina cells and identified two glutamate transporters: one Na+-dependent transporter and one Na+-independent transporter. The Na+-dependent uptake system presented characteristics related to the high-affinity xAG- system (EAAT1), and the Na+-independent uptake system presented characteristics related to the xCG- system, which highly contributes to glutamate transport in the retina. Glutamate shares the xCG- system with another amino acid, L-cysteine, suggesting the possible involvement of glutathione. Both transporter proteins are present mainly in Müller glial cells. GABA transporters (GATs) mediate high-affinity GABA uptake from the extracellular space and terminate the synaptic action of GABA in the central nervous system. GABA transporters can be modulated by molecules that act on specific sites to promote transporter phosphorylation and dephosphorylation. In addition to a role in the clearance of GABA, GATs may also release GABA through a reverse transport mechanism. In the chicken retina, a GAT-1 blocker, but not GAT2/3 blocker, was shown to inhibit GABA uptake, suggesting that GABA release from retina cells is mainly mediated by a GAT-1-like transporter.