Design and Characterization of Silicone and Surfactant Based Systems for Topical Drug Delivery

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento e validação de uma técnica quantitativa de análise de imagem para avaliação do teste do cometa corado pela prata

The comet assay is a method of DNA damage analysis widely used to quantify oxidative damage, crosslinks of DNA, apoptosis and genotoxicity of chemicals substances as chemical, pharmaceuticals, agrochemicals products, among others. This technique is suitable to detect DNA strand breaks, alkali-labile sites and incomplete excision repair sites and is based on the migration of DNA fragments by microeletroforesis, DNA migrates for the anode forming a “tail”, and the formed image has the appearance of a comet. The slides can be stained with fluorescence or silver, having differences in the microscopy type used for the analysis and the possibility of storage of the slides, moreover, the first one is a stained-method with more difficulties of accomplishment. The image analysis can be performed by a visual way, however, there is a disadvantage as the subjectivity on the results, that can be minimized by an automated method of digital analysis. This process was studied in this report with the aim to perceive the validation of the digital analysis turning it a quantitative method with larger reproductibility, minimizing the variability and imprecision due to the subjective analysis. For this validation we selected 50 comets photographed in a standardized way and printed, afterwards, pictures were submitted to three experienced appraisers, who quantified them manually. Later, the images were processed by free software ImageJ 1.38x, printed and quantified manually by the same appraisers. The intraclass correlation was higher to comet measures after image processing. Following, an algorithm of automated digital analysis from the measures of the comet was developed; the values obtained were compared with those 12 estimated manually after the processing resulting high correlation among the measures. The use of image analysis systems increases ...(Complete abstract click electronic access below)

Diagnóstico da gestão e do gerenciamento dos resíduos eletroeletrônicos gerados no campus da Faculdade de Engenharia de Guaratinguetá/Unesp

Currently, in Brazil, the quantity and quality of new types of wastes, discarded without criteria in urban areas, has been responsible for considerable impacts on public health and the environment. According to a report prepared by the Institute of Applied Economic Research (IPEA), the country loses about U.S. $ 8 billion annually, due lack of waste recycling, which go directly into landfills or dumps. Among these solid wastes are waste electrical and electronic equipment (WEEE), whose characteristics are complex, by having in its composition substances of high value-added and other health hazards which require different treatment of household waste. Aiming to fill the gap in Brazilian environmental legislation, on 02/08/2010, was sanctioned the National Policy Solid Waste (Law No. 12,305), already regulated on 23/12/2010 (Decree No 7404), whose based on the following principles:reduction of waste generation and toxicity of shared responsibility, proper planning management, social inclusion of waste pickers and sustainable production and consumption. Given the above, this work presented here, aims generally present a diagnosis of the current situation of electronic waste generated in the Faculty of Engineering, Campus Guaratinguetá, FEG / UNESP, to provide data for management and management of these waste, based on sustainability, the economic losses and minimizing environmental impacts and public health related to the flow and the improper disposal of these wastes

Deslocamento de caráter em hilídeos neotropicais (anura: hylidae)

The interspecific competition tends to favor the selection of divergent phenotypes minimizing the effect of this interaction. This process is termed character displacement and it is considered one of the main mechanisms promoting adaptive diversification. Brazil has the greatest diversity of amphibians on the planet and despite this great diversity; the role of character displacement in the process of Brazilian amphibian fauna diversification has not been studied. In the present study we tested the hypothesis of character displacement in four congeneric species pairs of frogs from the family Hylidae, occurring in the Atlantic Forest and Cerrado. We find evidence of character displacement for two pairs and parallel evolution for the remaining. Interestingly, the trend of character displacement was in species whose range covers less stable habitats. Since this is a pioneering study with neotropical hylid, we discussed issues considered relevant to elucidate mechanisms related to the maintenance of diversity

Análise crítica de contratos técnicos como ferramenta para melhoria da gestão da manutenção

Currently, due to the highly competitive search among industries are becoming more tools for managing product that provides higher availability and therefore profitability. Maintenance as a strategic sector and of fundamental importance in business, it seeks to maximize availability and available resources, minimizing costs and waste, which directly impacts the company's results. The present work has as main objective the review of contracts for maintenance services for companies contracted by a chemical company in the Paraíba Valley, since most of its maintenance services are outsourced, and raise these contracts which are more critical and higher risk to the company's success, thus creating a tool for decision-making by maintenance managers in the act of seeking renewals or new contracts to provide services. As a result after drawing up a standard procedure for contracting of services and a better structuring of the same, we developed a method for the calculation of the criticality of the contracts and based on these calculations, charts were prepared which showed that the current scenario of maintenance contracts the company studied. Thus it is possible to evaluate the contracts which are most critical to the success or failure of the company studied, and also pave the way for further studies on how this criticality of a contract can affect the relationship, the contractor x contracted

Feiras de negócios: o estande que fala : o Relações Públicas no planejamento estratégico de estandes para Feiras de Negócios, da estruturação à mensuração de resultados

All the time, organizations are seeking ways to relate to their audiences, in order to become stronger institutionally and merchandising. In the era of information technology contacts occur increasingly in virtual form, minimizing the face-to-face. Thus, this study contextualizes the trade fairs as a way to bring business relations / public interest in a real environment and provides the friendly atmosphere, much as in a short time, the company with a large amount of their customers, potential customers, partners, suppliers, and other audiences that may be interesting. However, shows that for the success of these events is a necessary strategic planning, so that subsequent implementation is possible to measure the results. It also envisions the trade fairs getting a new format, that is, their commercial character to give the space for the relational as a way to bring more awareness to organizations and to strengthen ties with their audiences. This beneath the optics of Public Relation as the appropriate professional to manage relationships and therefore be the strategist of the company's participation in a trade fair

Avaliação do gerenciamento e disposição final dos resíduos químicos de laboratórios do IGCE, UNESP - Rio Claro/SP

Laboratory of Chemical Waste Management programs are being implemented in various universities of the country and the world, in recognition of the urgent need to change the reality of disregard for the environment, together with objective responsibility of the generator, and especially the awareness of sustainability. Analysis and research laboratories involve a range of waste in developing their studies with intrinsic characteristics related to their form of generation. The amount of waste generated in this segment is negligible compared to industrial activities, but the environmental issue is that these residues do not have a standard technique for treatment due to the potential variation of its composition. This research project, aiming their suitability and continuous improvement, aims to diagnose and analyze the current situation of the management and disposal of chemical waste generated by the laboratories IGCE UNESP, Campus Rio Claro / SP. Universities, through their research, teaching and extension, end up generating potentially hazardous chemicals that may contaminate the environment when they are disposed of improperly, with no concern for the environment and / or public health. Aiming to assist in improvements with respect to this issue, the purpose of this study is to understand the management and disposal of chemical waste from the IGCE, laboratories UNESP - Rio Claro / SP, in order to discuss the situation of such waste, and present proposals to reduce generation of the same and minimizing the environmental impact, thereby increasing the local hygiene through proper disposal. The research instrument used interviews, questionnaires, review of recent literature and observations were made in order to develop proposals for the management and disposal of waste. These proposals based on prevention and corrective control, where the preventive approach aims at lifting techniques and actions to reduce the generating sources and...

Avaliação ambiental em empresas do distrito industrial Antônio Crepaldi, Presidente Prudente/SP

The sustainable development is the center of many discussions about the environment, economy and society. Environmental issues bring out problems with the fauna and flora, water resources, land use, population growth, residues, basic sanitation, and others. In this sense, the aim of the present work was to develop an environmental diagnostics and propose measures to mitigate the most significant environmental impacts generated by four enterprises in Antonio Crepaldi Industrial District, located at the city of Presidente Prudente/SP. In the study, it was used the methodology proposed by Moreira (2006), and it was done the following activities: monitoring and analyses of the production process, identification of potential environmental aspects and impacts; assessment of the impacts according to its nature, relevance and significance; proposition of measures to mitigate the critical impacts. As a final result, it was obtained an environmental diagnosis about the situation of each of the four companies studied, and it was possible to know the level of criticality of the impacts in each one, and proposing mitigation measures to control or minimizing them, bringing many benefits to the organization

Mapeamento de áreas susceptíveis para implantação de aterro sanitário no município de Rio Claro, SP

The inadequate disposal of municipal waste is one of the biggest environmental problems. The lack of long public politics makes this problem a challenge to their administrators. Finding a place for the disposal of waste is an easy task and the present work looks forward to a better understanding about the concepts involved in order to choose favorable areas for the development of sanitary landfills, minimizing environmental impacts. In this line of thought several areas in Rio Claro`s region were evaluated according to the environmental terms. The areas which were classified as good or almost good will have a more elaborated study such as field works, evaluation and understanding of the concepts analyzed so that there aren’t any waste of money, work, social and environmental waste in the area. These areas were analyzed according to secondary data such as geological and pedological formation and primary studies such as the assumption of the reality as showed in the map will be made in order to acquire better results.

Sistema de cálculo computacional da unidade monitora para feixes de elétrons em radioterapia

In radiation theraphy with electron beam, the electrons are produced in linear accelerators, and energy the most used have between 4MeV and 20MeV. Generally, the treatments are done for superficial injuries, because the low penetration of these particles. In this work a system for calculation of monitor units (U.M.) for cases of treatments with electron beam was developed. The Excel program of Microsoft was used and is easily found in the operational system of the personal microcomputers. In the Excel has been inserted the pertinent data of the linear accelerator of Varian, model 2100C, used in the Service of radiation theraphy of the Hospital of the Clinics of the College of Medicine of the UNESP of Botucatu. For some values of the physical parameters, such as: factors field and factors calibration, not supplied in the tests of acceptance of the machine, still proceeded calculations from interpolation and extrapolation. The mathematical formulas for automatic search of these and others factors used in the calculations of the determination of the U.M had been developed in agreement available routines in Excel. For this the functions had been used the function IF (that it imposes search condition) and the PROCH (that looks a value in a column from determined line), beyond the basic functions of addition, multiplication and division. It is intended to optimize the routine of the Services of radiation theraphy that perform through eletrontheraphy procedures, speeding the calculations and minimizing the occurrence of errors and uncertainties deriving of the maken a mistake manipulation of the parameters gotten in tables of data of electron beams

Os cadernos de física: algumas inquietações sobre o currículo oficial do Estado de São Paulo

The assumptions of Marxist philosophy helps us understand the inherent contradictions of the historical process. The category mode of production is understood as the means and the ends for which mankind produces and reproduces reality objectively and subjectively. The temporal evolution of the mode of production has spurred antagonistic social classes, which are the world capitalist bourgeoisie and proletariat. At the rise of the current mode of production each class produced a pedagogy according to your interests. The proposal of the workers is centered on unity between teaching and non-alienated labor, enabling the development of human potential and building a new social order. The last historical period was marked by the implementation of the neoliberal agenda to reduce social spending and market liberalization. The educational reforms of the state of São Paulo followed the same goals. From the program São Paulo Faz Escola, São Paulo School Curriculum was introduced in the State of São Paulo, which integrates several documents. The Student Notebook, separated by discipline and delivered bimonthly to students of public schools, is one of those publications. Specifically, the physics notebook brings a content with no depth, where theories are presented by minimizing the mathematical formalism for a broad education that meets the needs for dynamize the economy

Análise de risco em carteiras

The work consists of analyzing the risk management of investments by applying statistical concepts, economic and mathematical models considering the assets on the market on renowned financial institution. The assessment of these risks becomes increasingly interesting in view of minimizing your losses thus maximizing your chances of gains in both markets boom as extreme uncertainty, even with the sudden changes of scenery. Introducing concepts of investment funds, as well as the classification of the types of funds as funds management and equity, its guidelines, the concept of market investment funds. The types of assets comprising the investment funds, their taxation rules beyond the incidents that market widely used by investors and skilled people, both physical and legal, who keep their resources in this modality. With the historical data collected yields of investment funds of the Bank of Brazil, is an accomplished inflation adjustment and calculated the mean and variance for the verification of the model of Markowitz efficient frontier, a method used as investment analysis. This scan is used Matlab to obtain the set (or border) efficient portfolios. Once verified such data, there will be a critique of the Markowitz model as a quadratic programming and more coherent risk measures currently studied as VaR and CVaR minimizing the expected error, approaching our studies of current research. It is found that such studies have much to be explored, since there are many discussions about how effectively measure risk investments such as its characteristic and behavior, using a time series and volatility

Principais aspectos cirúrgicos da urolitíase em cães

Urolithiasis occurs with relatively frequency among the diseases that affect the urinary tract of dogs. It`s fundamental that samples of the uroliths are sent for analysis, because, in agreement with the mineral composition of the urolith and also its location, the choice is made between the surgical treatment or the clinical dissolution. Cystotomy is the surgical technique more accomplished in the bladder of small animals, due to its simplicity, when in comparison with other procedures for removal of calculi. With the aid of lithotripsy and endoscopy, the surgical interventions in the urinary treatment tend to be less and less invasive, minimizing the risks of subsequent complications. Chances of recurrence of the urolithiasis are usually larger in patients submitted to the surgical intervention. Besides, the time elapsed among regressive episodes is larger after the clinical dissolution

Prevalência de nematódeos em ovinos (Ovis aries) pertencentes a diferentes microrregiões do estado de São Paulo, Brasil

Pós-graduação em Medicina Veterinária - FCAV

Desenvolvimento de um smart meter: um estudo sobre eficiência energética através das redes inteligentes

Pós-graduação em Engenharia Elétrica - FEB