Report of the Workshop to Provide an Introduction to Basic Techniques for Library Organization and Services

Informe del taller de trabajo de capacitación en métodos de organización de colecciones, especialmente algunas de documentos adquiridos recientemente, y métodos para proveer acceso a la información y mejorar los servicios para los usuarios, en bibliotecas y servicios de información en San Vicente.

Questionnaire analysis special library units in the Republic of Trinidad and Tobago establishment, location and orientation of units

Includes bibliography

As tecnologias da Web Semântica no domínio bibliográfico

Pós-graduação em Ciência da Informação - FFC

The United States and Latin America and the Caribbean: highlights of economy and trade

Document prepared on the occasion of the visit of President Barack Obama to Brazil, Chile and El Salvador in March 2011

Airport systems: public service and private initiative

This issue analize the importance of air travel among other forms of transport has greatly increased, offering a viable option for the movement of people and goods.

Report of the planning meeting of partners of the Caribbean Information Societies Measurement Initiative

The Planning Meeting of Partners was organized jointly by the Economic Commission for Latin America and the Caribbean (ECLAC) Subregional Headquarters for the Caribbean, the Observatory for the Information Society in Latin America and the Caribbean (OSILAC - an ECLAC project supported by the International Development Research Centre (IDRC), the University of West Indies (UWI), St. Augustine Campus and the Telecommunications Policy and Management Programme, Mona School of Business at UWI, Jamaica. The Caribbean Information Societies Measurement Initiative (CISMI) is a component of the research proposal entitled “Networks for Development: The Caribbean ICT Research Programme”, recently submitted to IDRC for funding approval. The main objective of this programme is to “promote multi-stakeholder knowledge exchange and dialogue about the potential contribution of Information and Communications Technology for economic development and poverty alleviation in the Caribbean” The proposed budget for the CISMI component within the aforementioned proposal is US$ 150,000. The main objectives of the CISMI component are twofold: (a) to conduct a comprehensive Information and Communications Technology (ICT) survey in the Caribbean subregion to cover baseline information needs for studies and analysis from different partners involved in the construction of the Caribbean Information Societies; and (b) to analyze the household-level data, including the status of broadband and mobile usage in selected Caribbean countries in order to promote evidence-based policy planning and implementation with respect to ICT development and its impact on social and economic development in the subregion. The Planning Meeting of Partners was convened to: (a) discuss the CISMI component partnership arrangements, (b) discuss the design and implementation mechanisms of the survey instrument (questionnaire); (c) inform and engage potential key stakeholders; and (d) obtain information from potential service providers (survey companies). The Planning Meeting of Partners took place on 28 and 29 September 2009 in Port of Spain, Trinidad and Tobago.

O professor mediador de leitura na biblioteca escolar da rede municipal de Londrina: formação e atuação

Pós-graduação em Educação - FFC

Os discursos do jornal impresso O Liberal sobre violência escolar em Belém (2001-2010)

O presente trabalho investiga os discursos da mídia impressa (jornal), acerca da violência escolar em Belém do Pará, no período de 2001 a 2010. Ante tal iniciativa, aponta-se como questão norteadora do estudo, saber: Qual o(s) significado(s) e sentido(s) de violência escolar produzidos nos discursos do jornal impresso “O Liberal” em Belém, no período de 2001- 2010? Com o objetivo de: a) investigar quais os significados e sentidos produzidos pelo jornal impresso “O Liberal”, em Belém, no período de 2001-2010; (b) identificar qual a recorrência de matérias sobre violência escolar no jornal impresso “O Liberal” em Belém, no período de 2001-2010; (c) verificar que discursos são materializados no jornal impresso “O Liberal” em Belém, no período de 2001-2010, sobre a violência escolar, e por fim, (d) identificar a relação das imagens fotográficas com a construção discursiva do jornal impresso de “O Liberal”, em Belém, no período de 2001-2010, sobre violência escolar. E, uma vez partindo dos pressupostos da pesquisa documental, o corpus da pesquisa exploratória constitui-se de duzentos e sessenta (260) peças jornalísticas, levantadas junto à Biblioteca Pública Arthur Vianna (CENTUR). A partir desse corpus de 260 peças jornalísticas, consideramos vinte (20) peças jornalísticas, para compor o corpus de análise dessa dissertação, que se destaca por seu tratamento explícito e nomeado da violência escolar. A análise dar-se-á à luz da teoria/análise do discurso bakhtiniano; para a qual, todo discurso está impregnado de intenções ideológicas, o que dá significado e sentido às mensagens da mídia. O exame dos achados nos proporcionou concluir que, o número de publicações de peças com teor explícito na abordagem da violência escolar é muito pequeno em relação ao período estudado. Constatou-se também que o jornal “O Liberal” possui um posicionamento acerca da violência escolar que busca consolidar sempre que a aborda por meio da apropriação de falas testemunhais e do discurso científico. Verificou-se ainda que, a teia discursiva das matérias jornalísticas analisadas conjuga basicamente dez elementos quase sempre reiteráveis, sobre os quais compõe sentidos e apreciações que extrapolam significações dicionarizadas; em cuja trama, a imagem funciona como partícipe do movimento enunciativo que, da mesma forma evidencia a figura do aluno como principal ator das ocorrências violentas na escola e do fenômeno como caso de polícia e recursos de segurança. Neste sentido, espera-se poder contribuir para uma apreciação crítica da mídia em suas dimensões próprias de construção dos debates públicos; assim como para uma compreensão da violência escolar no âmbito da sua veiculação.

Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library

Chikungunya virus (CHIKV) is a mosquito-borne arthrogenic alphavirus that causes acute febrile illness in humans accompanied by joint pains and in many cases, persistent arthralgia lasting weeks to years. The re-emergence of CHIKV has resulted in numerous outbreaks in the eastern hemisphere, and threatens to expand in the foreseeable future. Unfortunately, no effective treatment is currently available. The present study reports the use of resazurin in a cell-based high-throughput assay, and an image-based high-content assay to identify and characterize inhibitors of CHIKV-infection in vitro. CHIKV is a highly cytopathic virus that rapidly kills infected cells. Thus, cell viability of HuH-7 cells infected with CHIKV in the presence of compounds was determined by measuring metabolic reduction of resazurin to identify inhibitors of CHIKV-associated cell death. A kinase inhibitor library of 4,000 compounds was screened against CHIKV infection of HuH-7 cells using the resazurin reduction assay, and the cell toxicity was also measured in non-infected cells. Seventy-two compounds showing >= 50% inhibition property against CHIKV at 10 mu M were selected as primary hits. Four compounds having a benzofuran core scaffold (CND0335, CND0364, CND0366 and CND0415), one pyrrolopyridine (CND0545) and one thiazol-carboxamide (CND3514) inhibited CHIKV-associated cell death in a dose-dependent manner, with EC50 values between 2.2 mu M and 7.1 mu M. Based on image analysis, these 6 hit compounds did not inhibit CHIKV replication in the host cell. However, CHIKV-infected cells manifested less prominent apoptotic blebs typical of CHIKV cytopathic effect compared with the control infection. Moreover, treatment with these compounds reduced viral titers in the medium of CHIKV-infected cells by up to 100-fold. In conclusion, this cell-based high-throughput screening assay using resazurin, combined with the image-based high content assay approach identified compounds against CHIKV having a novel antiviral activity -inhibition of virus-induced CPE - likely by targeting kinases involved in apoptosis.