Indenture between Henry Hope Graham and Robert Hill to Joseph Walker

Indenture of deed of land situate between Henry Hope Graham and Robert Hill, both of London, England called England Esquire Executors and Trustees under the Last Will and Testament of Lieutenant General Percy Hill of London, England to Joseph Walker of Queenston, Ontario. This is in regard to parts of Lots no. 113, 114 and 115 in the Township of Niagara. This was registered on Nov. 10, 1885 – instrument no. 2075, Oct. 31, 1885.

Invitation to the Funeral of Infant Henry Howard Woodruff

Invitation to the funeral of infant Henry Howard Woodruff on March 17, 1868. He was the son of Henry and Emma Woodruff. This is accompanied by an envelope. March 16, 1868.

Letter - Henry O'Laughlin to H.K. Woodruff

Letter from Henry O’Laughlin, secretary of the Central Fire Station of St. Catharines, Ont. to H.K. Woodruff informing him that he was elected as an active member of the Citizens’ Hose Co. No. 1, March 14, 1883.

Indenture Abraham Fuller Atkinson, Henry Riggs Goodman and William Hamilton Merritt to Thomas Lees Helliwell

Indenture between Abraham Fuller Atkinson of St. Catharines, rector of St. George’s Church, Henry Riggs Goodman and William Hamilton Merritt, wardens of St. George’s Church, to Thomas Lees Helliwell for pew no. 15 in St. George’s Church, Mar. 21, 1857.

Postcard Addressed to Mr. Henry Woodruff

Postcard addressed to Mr. Henry Woodruff of St. Davids regarding 33 bags placed to Mr. Woodruff’s credit. The postcard is signed by John May, Aug. 6, 1883.

Crick, Henry A., includes Application for Loan, and Mortgage Loan Envelope

Crick, Henry A., includes Application for Loan, Jan. 8, 1885 and Mortgage Loan Envelope no. 637 for Jan. 1, 1885 – Jan. 1, 1890.

Letter addressed to “dear sir” signed by Roland R. Conklin

Letter (1 page, typed) addressed to “dear sir” with a request to please forward your coupons for collection about 30 days before they become due. This is signed by Roland R. Conklin, secretary of Jarvis-Conklin Mortgage Trust Company, June 1, 1889.

License no. 67 of season 1873/74 made out to S.D. Woodruff for 36 square miles in berth no. 192

License no. 67 of season 1873/74 made out to S.D. Woodruff for 36 square miles in berth no. 192, June 13, 1873

License no. 68 of season 1873/74 made out to S.D. Woodruff for 35 ¾ square miles in berth no. 198

License no. 68 of season 1873/74 made out to S.D. Woodruff for 35 ¾ square miles in berth no. 198, June 13, 1873.

Letter to S.D. Woodruff regarding a resolution passed that the engineer be requested to examine the fence built by the contractors alongside of the Henry Vandenburgh Farm

Letter to S.D. Woodruff regarding a resolution passed that the engineer be requested to examine the fence built by the contractors alongside of the Henry Vandenburgh Farm and report to the secretary as to whether this is a lawful fence, completed according to Williams’ contract. This is signed by Duncan McFarland, president. There is a reply written by S.D. Woodruff at the bottom of the letter stating that the fence is not built in accordance with the contract, Dec. 18, 1856.

Letter with the salutation “Dear Sir” It is signed by John I. Mackenzie in which he states that he got the Globe to publish a letter about the Long Point expats which had been sent to the Ottawa Times

Letter with the salutation “Dear Sir” It is signed by John I. Mackenzie in which he states that he got the Globe to publish a letter about the Long Point expats which had been sent to the Ottawa Times. Most of the handwriting is illegible, Oct. 26, 1870.

Letter from John I. Mackenzie with the salutation “Dear Sir”

Letter from John I. Mackenzie with the salutation “Dear Sir” which states that Col. Tisdale and Hunter discussed the desirableness of transferring 5 of your shares over to Mackenzie (2 pages, handwritten). He also says that they will need funds for wages, March 28, 1878.

Letter (printed) with the salutation “Dear Sir”. The writer is John I. Mackenzie.

Letter (printed) with the salutation “Dear Sir”. The writer is John I. Mackenzie who outlines resolutions which were passed at the annual meeting of the Long Point Co., June 21, 1879.

Letter with the salutation “Dear Sir” and signed by Louis Cabot

Letter with the salutation “Dear Sir” and signed by Louis Cabot. He claims that he has written to George Richards to send a draft for $1,000.00 (2 pages, handwritten), March 23, n.d.

Mirroring Enzymes: The Role of H-Bonding In HQuin-BAM Catalyzed Asymmetric Aza-Henry Reactions: A DFT Study into the Reactivity, Mechanism, and Origins of Selectivity

The exact mechanistic understanding of various organocatalytic systems in asymmetric reactions such as Henry and aza-Henry transformations is important for developing and designing new synthetic organocatalysts. The focus of this dissertation will be on the use of density functional theory (DFT) for studying the asymmetric aza-Henry reaction. The first part of the thesis is a detailed mechanistic investigation of a poorly understood chiral bis(amidine) (BAM) Brønsted acid catalyzed aza-Henry reaction between nitromethane and N-Boc phenylaldimine. The catalyst, in addition to acting as a Brønsted base, serves to simultaneously activate both the electrophile and the nucleophile through dual H-bonding during C-C bond formation and is thus essential for both reaction rate and selectivity. Analysis of the H-bonding interactions revealed that there was a strong preference for the formation of a homonuclear positive charge-assisted H-bond, which in turn governed the relative orientation of substrate binding. Attracted by this well-defined mechanistic investigation, the other important aspect of my PhD research addressed a detailed theoretical analysis accounting for the observed selectivity in diastereoselective versions of this reaction. A detailed inspection of the stereodetermining C-C bond forming transition states for monoalkylated nitronate addition to a range of electronically different aldimines, revealed that the origins of stereoselectivity were controlled by a delicate balance of different factors such as steric, orbital interactions, and the extent of distortion in the catalyst and substrates. The structural analysis of different substituted transition states established an interesting dependency on matching the shape and size of the catalyst (host molecule) and substrates (guest molecules) upon binding, both being key factors governing selectivity, in essence, offering an analogy to positive cooperative binding effect of catalytic enzymes and substrates in Nature. In addition, both intra-molecular (intra-host) and inter-molecular (host-guest, guest-guest) stabilizing interactions play a key role to the high π-facial selectivity. The application of dispersion-corrected functionals (i.e., ωB97X-D and B3LYP-D3) was essential for accurately modeling these stabilizing interactions, indicating the importance of dispersion effects in enantioselectivity. As a brief prelude to more extensive future studies, the influence of a triflate counterion on both reactivity and selectivity in this reaction was also addressed.