The edge vascular response following implantation of the Absorb everolimus-eluting bioresorbable vascular scaffold and the XIENCE V metallic everolimus-eluting stent. First serial follow-up assessment at six months and two years: insights from the first-in-man ABSORB Cohort B and SPIRIT II trials

AIMS To assess serially the edge vascular response (EVR) of a bioresorbable vascular scaffold (BVS) compared to a metallic everolimus-eluting stent (EES). METHODS AND RESULTS Non-serial evaluations of the Absorb BVS at one year have previously demonstrated proximal edge constrictive remodelling and distal edge changes in plaque composition with increase of the percent fibro-fatty (FF) tissue component. The 5 mm proximal and distal segments adjacent to the implanted devices were investigated serially with intravascular ultrasound (IVUS), post procedure, at six months and at two years, from the ABSORB Cohort B1 (n=45) and the SPIRIT II (n=113) trials. Twenty-two proximal and twenty-four distal edge segments were available for analysis in the ABSORB Cohort B1 trial. In the SPIRIT II trial, thirty-three proximal and forty-six distal edge segments were analysed. At the 5-mm proximal edge, the vessels treated with an Absorb BVS from post procedure to two years demonstrated a lumen loss (LL) of 6.68% (-17.33; 2.08) (p=0.027) with a trend toward plaque area increase of 7.55% (-4.68; 27.11) (p=0.06). At the 5-mm distal edge no major changes were evident at either time point. At the 5-mm proximal edge the vessels treated with a XIENCE V EES from post procedure to two years did not show any signs of LL, only plaque area decrease of 6.90% (-17.86; 4.23) (p=0.035). At the distal edge no major changes were evident with regard to either lumen area or vessel remodelling at the same time point. CONCLUSIONS The IVUS-based serial evaluation of the EVR up to two years following implantation of a bioresorbable everolimus-eluting scaffold shows a statistically significant proximal edge LL; however, this finding did not seem to have any clinical implications in the serial assessment. The upcoming imaging follow-up of the Absorb BVS at three years is anticipated to provide further information regarding the vessel wall behaviour at the edges.

Analytical Models of Exoplanetary Atmospheres. II. Radiative Transfer via the Two-Stream Approximation

We present a comprehensive analytical study of radiative transfer using the method of moments and include the effects of non-isotropic scattering in the coherent limit. Within this unified formalism, we derive the governing equations and solutions describing two-stream radiative transfer (which approximates the passage of radiation as a pair of outgoing and incoming fluxes), flux-limited diffusion (which describes radiative transfer in the deep interior) and solutions for the temperature-pressure profiles. Generally, the problem is mathematically under-determined unless a set of closures (Eddington coefficients) is specified. We demonstrate that the hemispheric (or hemi-isotropic) closure naturally derives from the radiative transfer equation if energy conservation is obeyed, while the Eddington closure produces spurious enhancements of both reflected light and thermal emission. We concoct recipes for implementing two-stream radiative transfer in stand-alone numerical calculations and general circulation models. We use our two-stream solutions to construct toy models of the runaway greenhouse effect. We present a new solution for temperature-pressure profiles with a non-constant optical opacity and elucidate the effects of non-isotropic scattering in the optical and infrared. We derive generalized expressions for the spherical and Bond albedos and the photon deposition depth. We demonstrate that the value of the optical depth corresponding to the photosphere is not always 2/3 (Milne's solution) and depends on a combination of stellar irradiation, internal heat and the properties of scattering both in optical and infrared. Finally, we derive generalized expressions for the total, net, outgoing and incoming fluxes in the convective regime.

The Gests of King Alexander of Macedon; two middle-English alliterative fragments, Alexander A and Alexander B,

"Previous editions": p. 14-15.

A treatise of tenures, in two parts : containing I. The original, nature, use, and effect of feudal or common law tenures. II. Of custumary and copyhold tenures, explaining the nature and use of copyholds, and their particular customs, with respect to the duties of the lords, stewards, tenants, and suitors: with the nature of fines, forfeitures, hariots, escheats, descents, &c.

Spine title: Gilbert's tenures.

An account of the ceremonies observed in the coronations of the kings and queens of England : viz. King James II and his royal consort, King William III and Queen Mary, Queen Anne, King George I, and King George II and Queen Caroline.

In anticipation of the coronation of King George III.

The laws, ordinances and institutions of the Admiralty of Great Britain Civil and Military : comprehending, I. Such antient naval laws and customs as are still in use. II. An abstract of the Statutes in force relating to maritime affairs and commerce III. The Marine Treaties at large IV. A critical account of naval affairs and commerce, from the Reign of Alfred the Great. V. The present state of the navy, and of the officers, offices, ships [et]c. thereof. : interspers'd with dissertations, notes and comments for the use of the officers of the navy, masters of ship, mariners, merchants, insurers, and the trading part of the Nation in general : with a preface giving a more particular Account of the Nature, use and desing of this work : in two volumes ...

Mode of access: Internet.

The new pocket dictionary of the French and English languages : in two parts : I French and English, II English and French : containing all words of general use : and authorised by the best writers ... /

Mode of access: Internet.

An abridgment of Mr. Edwards's Civil and commercial history of the British West Indies : in two volumes, vol. I[-II]

Sabin 21904

Athenian letters: or, The epistolary correspondence of an agent of the king of Persia, residing at Athens during the Peloponnesian war. A new edition; to which is prefixed a geographical index. In two volumes. Illustrated with engravings, and a map of ancient Greece ...

The work of a group of English writers each letter being signed by an initial indicating the author, as follows. P.-Philip Yorke; C.-Charles Yorke; R.-G.H. Rooke; G.-John Green; W.-Daniel Wray; H.-Henry Heaton; E.-Wm. Heberden; O.-Henry Coventry; L.-John Lawry; T.-Catherine Talbot; B.-Thomas Birch; S.-Samuel Salter. The work was edited by Thomas Birch, the brothers Yorke having the largest share in the composition of the letters.

A new and improved Spanish grammar, designed for every class of learners, but especially for such as are their own instructors. In two parts: Part I. An easy introduction to the elements of the Spanish language. Part II. The rules of etymology and syntax fully exemplified, with occasional notes and observations.

Mode of access: Internet.

Eight chirurgical treatises, on these followings heads : (viz), I. Of tumors : II. Of ulcers : III. Of diseases of the anus : IV. Of the King's evil ... /

Mode of access: Internet.

Eight chirurgical treatises, on these followings heads : (viz), I. Of tumors : II. Of ulcers : III. Of diseases of the anus : IV. Of the King's evil ... /

Mode of access: Internet.

Eight chirurgical treatises, on these followings heads : (viz), I. Of tumors : II. Of ulcers : III. Of diseases of the anus : IV. Of the King's evil ... /

Mode of access: Internet.