A política de defesa do Japão na primeira década do Século XXI

Pós-graduação em Relações Internacionais (UNESP - UNICAMP - PUC-SP) - FFC

Whaling dispute continues

Apparently alarmed that an advertisement in Nature referencing the study of Baker and Palumbi (Science 265, 1538; 1994) might lend undeserved credence to the notion that illegal whale products find their way into Japanese markets, Milton Freeman (Nature 376, 11; 1995) reiterates the arguments of the Fisheries Agency of Japan (FAJ) that the study is fundamentally flawed. As Freeman's letter contains several serious errors, we feel obliged to comment.

DNA damage profiles induced by sunlight at different latitudes

Despite growing knowledge on the biological effects of ultraviolet (UV) radiation on human health and ecosystems, it is still difficult to predict the negative impacts of the increasing incidence of solar UV radiation in a scenario of global warming and climate changes. Hence, the development and application of DNA-based biological sensors to monitor the solar UV radiation under different environmental conditions is of increasing importance. With a mind to rendering a molecular view-point of the genotoxic impact of sunlight, field experiments were undertaken with a DNA-dosimeter system in parallel with physical photometry of solar UVB/UVA radiation, at various latitudes in South America. Onapplying biochemical and immunological approaches based on specific DNA-repair enzymes and antibodies, for evaluating sunlight-induced DNA damage profiles, it became clear that the genotoxic potential of sunlight does indeed vary according to latitude. Notwithstanding, while induction of oxidized DNA bases is directly dependent on an increase in latitude, the generation of 6-4PPs is inversely so, whereby the latter can be regarded as a biomolecular marker of UVB incidence. This molecular DNA lesion-pattern largely reflects the relative incidence of UVA and UVB energy at any specific latitude. Hereby is demonstrated the applicability of this DNA-based biosensor for additional, continuous field experiments, as a means of registering variations in the genotoxic impact of solar UV radiation. Environ. Mol. Mutagen. 2012. (c) 2012 Wiley Periodicals, Inc.