Efficiency calibration of neutron detector array for beta decay of exotic nuclei

The research of the in-beam efficiency calibration of Neutron Detector Array of Peking University using N-17 and C-16 beams was introduced in this paper. The efficiency of neutron wall and ball are comparable to the foreign similar devices and neutrons can be detected from low to high energies in high efficiency.

Study of buncher efficiency in axial injection system of SFC

In order to reduce the influence of the stray electric field of the buncher in the axial injection system of SFC and to improve the injection efficiency of SFC, the existing buncher electrode is investigated and a new electrode is designed. The influences of the electric field to the beams for the both cases are simulated. The simulation results show that the bunching efficiency is improved from 55% to 74% with the new electrode. At the same time, the influence of the space charge is computed and according to the results, the location of the buncher is readjusted too.

High-efficiency transfer and expression of AdCMV-p53 in human hepatocellular carcinoma cells induced by low-dose carbon-ion radiation

Objective To investigate whether the irradiation with C-beam could enhance adenovirus-mediated transfer and expression of p53 in human hepatocellular carcinoma. Materials and methods HepG2 cells were exposed to C-beam or gamma-ray and then infected with replicationdeficient adenovirus recombinant vectors containing human wild-type p53 or green fluorescent protein, respectively. The transfer efficiency and expression level of the exogenous gene were detected by flow cytometric analysis. Cell survival fraction was detected by clonogenic assay. Results The transfer frequency in C-beam or gamma-irradiated groups increased by 50-83% and 5.7-38.0% compared with the control, respectively (P < 0.05). Compared with C-beam alone, p53 alone, and gamma-ray with p53, the percentages of p53 positive cells for 1 Gy C-beam with p53 increased by 56.0-72.0%, 63.5-82.0%, and 31.3-72.5% on first and third day after the treatments, respectively (P < 0.05). The survival fractions for the 2Gy C-bearn and AdCMV-p53 infection groups decreased to similar to 2%. Conclusion C-beam irradiation could significantly promote AdCMV-green fluorescent protein transfer and expression of p53.

分离扇回旋加速器的接受度及效率；Acceptance and efficiency of sector-separated cyclotron

以9.7MeV/u的238U36+,5.62MeV/u的70Zn10+为典型离子,分析并模拟了分离扇回旋加速器(SSC)的注入、加速和引出,得到了SSC在理论等时场下横向和纵向的接受度。为了研究SSC在实际情况下的接受度,在实测场的基础上采用Kr-Kb方法以及Lagrange插值方法建立了与实际比较符合的等时场,计算了该等时场下SSC横向和纵向的接受度,发现了导致SSC实际接受度和传输效率低的主要原因在于注入系统中的MSI3元件和引出系统中的MSE3元件设计存在缺陷。模拟结果显示,通过改变MSI3和MSE3的曲率或者垫铁改变元件内部的场分布可以改善SSC的实际接受度和传输效率。

Efficiency Dynamics on Two Coupled Small-World Networks

We investigate the effect of clusters in complex networks on efficiency dynamics by studying a simple efficiency model in two coupled small-world networks. It is shown that the critical network randomness corresponding to transition from a stagnant phase to a growing one decreases to zero as the connection strength of clusters increases. It is also shown for fixed randomness that the state of clusters transits from a stagnant phase to a growing one as the connection strength of clusters increases. This work can be useful for understanding the critical transition appearing in many dynamic processes on the cluster networks.

EFFICIENCY DYNAMICS ON SCALE-FREE NETWORKS WITH COMMUNITIES

The simple efficiency model is developed on scale-free networks with communities to study the effect of the communities in complex networks on efficiency dynamics. For some parameters, we found that the state of system will transit from a stagnant phase to a growing phase as the strength of community decreases.

Structural determinants of steroids for cytochrome P450 3A4-mediated metabolism

Cytochrome P450 3A4 (CYP3A4), a major member of cytochrome P450 isoenzymes, metabolizes the majority of steroids in 6beta-position. For the purpose of determining requisite structural features of a series of structurally related steroids for CYP3A4-mediated metabolism, three-dimensional pharmacophore modeling as well as electrotopological state map were conducted for 15 steroids. Though prior studies speculated that the chemical reactivity of the allylic 6beta-position might have a greater influence on CYP3A4 selective 6-hydroxylation than steric constraints in the enzyme, our results reveal that for CYP3A4 steroidal substrates, it is not the chemical reactivity of atoms at 6beta-site, but the pharmacophoric features, i.e. the two hydrophobic rings together with two H-bond donors, that act as the key factors responsible for detemining the CYP3A4 selective 6-hydroxylation of steroids. (C) 2004 Elsevier B.V. All rights reserved.

Precipitation-use efficiency along a 4500-km grassland transect

National Natural Science Foundation of China [30590381, 40971027]; State Key Technologies RD Program [2006BAC08]; Chinese Academy of Sciences ; National Key Research and Development Program [2010CB833501]