Inhibition of reactive oxygen species production ameliorates inflammation induced by influenza A viruses via upregulation of SOCS1 and SOCS3.

Highly pathogenic avian influenza virus infection is associated with severe mortality in both humans and poultry. The mechanisms of disease pathogenesis and immunity are poorly understood although recent evidence suggests that cytokine/chemokine dysregulation contributes to disease severity following H5N1 infection. Influenza A virus infection causes a rapid influx of inflammatory cells, resulting in increased reactive oxygen species production, cytokine expression, and acute lung injury. Proinflammatory stimuli are known to induce intracellular reactive oxygen species by activating NADPH oxidase activity. We therefore hypothesized that inhibition of this activity would restore host cytokine homeostasis following avian influenza virus infection. A panel of airway epithelial and immune cells from mammalian and avian species were infected with A/Puerto Rico/8/1934 H1N1 virus, low-pathogenicity avian influenza H5N3 virus (A/duck/Victoria/0305-2/2012), highly pathogenic avian influenza H5N1 virus (A/chicken/Vietnam/0008/2004), or low-pathogenicity avian influenza H7N9 virus (A/Anhui/1/2013). Quantitative real-time reverse transcriptase PCR showed that H5N1 and H7N9 viruses significantly stimulated cytokine (interleukin-6, beta interferon, CXCL10, and CCL5) production. Among the influenza-induced cytokines, CCL5 was identified as a potential marker for overactive immunity. Apocynin, a Nox2 inhibitor, inhibited influenza-induced cytokines and reactive oxygen species production, although viral replication was not significantly altered in vitro. Interestingly, apocynin treatment significantly increased influenza virus-induced mRNA and protein expression of SOCS1 and SOCS3, enhancing negative regulation of cytokine signaling. These findings suggest that apocynin or its derivatives (targeting host responses) could be used in combination with antiviral strategies (targeting viruses) as therapeutic agents to ameliorate disease severity in susceptible species.

From chemical warfare to peace

Following the horrors of chemical warfare in two World Wars and the Vietnam War (see box), the international community worked to develop an encompassing treaty to prevent the use of chemical weapons. After extensive work, the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction came into force in 1997. Commonly known as the Chemical Weapons Convention (CWC), it requires member states to declare and destroy chemical weapons and provides for inspection of facilities and investigation into alleged use. The CWC has been ratified by 190 countries and is administered by the Organisation for the Prohibition of Chemical Warfare (OPCW). In 2013, the OPCW won the Nobel Peace prize "for its extensive efforts to eliminate chemical weapons". Notable in the official announcement is the reminder that neither the US nor Russia met the 2012 deadline for destruction of their stockpiles of chemical weapons, although both have made significant progress. In July 2005, an invitational joint International Union of Pure and Applied Chemistry (IUPAC)/OPCW Conference concluded that for the work of OPCW to succeed and be sustainable, engagement in formal educational contexts and public outreach was needed. To this end, the Multiple Uses of Chemicals website

Asia and the autobiographical picture book

The Asia literacy curriculum objectives in Australian primary school classrooms are currently hampered by the scarcity of quality narrative picture books about Asian countries. Few books engage children without also representing Asia problematically. Anh Do’s The Little Refugee asserts an authentic cultural insider perspective on both Vietnam and Australia. In fact, it presents a paternalistic view of Asia and a self-congratulatory vision of Australia. This presentation engages with the picture book and life-writing genres to highlight the pitfalls and possibilities of using the autobiographical picture book to promote Asia literacy.

Public relations practice in ASEAN nations: local, regional, global visions

 This thesis examines the views, concerns and outlooks of public relations practitioners in six countries of South East Asia, seeking to understand the extent to which their views about their work and their world correspond with those of practitioners in the developed countries of the west. It reveals a range of distinctive issues and concerns requiring greater recognition in international public relations literature.

Has China displaced its competitors in high tech trade?

This paper empirically investigated the extent to which China displaced its competitors in high-tech exports using disaggregated data for the period 1992–2013. To address the endogeneity problem, we used a comprehensive set of instruments for Chinese high-tech exports in relevant markets, including China's GDP and distances to those markets. Results of our IV regressions revealed that in most of the high-tech sectors, Chinese exports had displaced the exports of its developing competitors such as India, South American exporters like Brazil and Mexico, and South-East Asian countries like Malaysia, Singapore, Thailand and Vietnam, especially in the period prior to the 2007–08 global financial crisis. Yet, Chinese exports had been associated with more high-tech exports of developed exporters like OECD countries, South Korea and Japan. Our findings suggest that while China became the world's top high-tech exporter, its high-tech exported products had been substitutes to those of other developing and emerging economies but complementary to that of developed economies.

Interview with Dennis Stamper

In his January 12, 2015 interview with Michelle Dubert-Bellrichard, Dennis Stamper shares his memories of being one of the first male, day students from 1969-1972. Stamper details his studies and professors from the Philosophy and Religion Department, as well as the Psychology Department. Stamper includes his perception of the atmosphere at Winthrop during a time of great change in the country, and how that experience coupled with his work in the Wesley Foundation and the influence he received from professors paved the way for he currently lives his life. Stamper concludes his interview detailing his studies and careers after Winthrop. This interview was conducted for inclusion into the Louise Pettus Archives and Special Collections Oral History Program.

Apocalypse now e o coração das trevas: o embate entre indivíduo e sociedade

O filme Apocalypse Now (1979), de Francis Ford Coppola, inspirado no romance O Coração das Trevas (1902), de Joseph Conrad, discute o conflito entre indivíduo e sociedade no contexto da Guerra do Vietnã, nos anos 60 e 70 do século XX. Este trabalho pretende mostrar, embasado pela Semiótica francesa, as estratégias utilizadas pelo diretor para explicitar essa oposição na linguagem cinematográfica e preservar a fidelidade temática em relação às questões abordadas pelo livro, passado durante o Imperialismo britânico na África, no século XIX.

The history of the introduction of the giant river prawn, Macrobrachium cf. rosenbergii (Decapoda, Palaemonidae), in Brazil: new insights from molecular data

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Tecnología de la información y las comunicaciones (TIC) para el fomento de las PYMES exportadoras en América Latina y Asia Oriental

Incluye Bibliografía

Poder e violência: Hannah Arendt e a Nova Esquerda

Pós-graduação em Ciências Sociais - FFC

Morfologia e germinação de sementes de tamareira-anã (Phoenix roebelenii O'Brien)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A reavaliação da Guerra do Vietnã apresentada no romance The short timer (197(), de Gustav Hasford, e em sua adaptação fílmica Fullmetal JAcket (1987), de Stanley Kubrick

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

The history of the introduction of the giant river prawn, Macrobrachium cf. rosenbergii (Decapoda, Palaemonidae), in Brazil: new insights from molecular data

The giant river prawn, Macrobrachium cf. rosenbergii, is one of the most cultivated freshwater prawns in the world and has been introduced into more than 40 countries. In some countries, this prawn is considered an invasive species that requires close monitoring. Recent changes in the taxonomy of this species (separation of M. rosenbergii and M. dacqueti) require a re-evaluation of introduced taxa. In this work, molecular analyses were used to determine which of these two species was introduced into Brazil and to establish the geographic origin of the introduced populations that have invaded Amazonian coastal waters. The species introduced into Brazil was M. dacqueti through two introduction events involving prawns originating from Vietnam and either Bangladesh or Thailand. These origins differ from historical reports of the introductions and underline the need to confirm the origin of other exotic populations around the world. The invading populations in Amazonia require monitoring not only because the biodiversity of this region may be affected by the introduction, but also because admixture of different native haplotypes can increase the genetic variability and the likelihood of persistence of the invading species in new habitats.

As posições políticas de Jean-Paul Sartre e o Terceiro Mundo (1947-1979)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)