984 resultados para Change-points
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The role of interferon-gamma in autoimmune diabetes was assessed by breeding a null mutation of the interferon-gamma receptor alpha chain into the nonobese diabetic mouse strain, as well as into a simplified T cell receptor transgenic model of diabetes. In contrast to a previous report on abrogation of the interferon-gamma gene, mutation of the gene encoding its receptor led to drastic effects on disease in both mouse lines. Nonobese diabetic mice showed a marked inhibition of insulitis-both the kinetics and penetrance-and no signs of diabetes; the transgenic model exhibited near-normal insulitis, but this never evolved into diabetes, either spontaneously or after experimental provocation. This failure could not be explained by perturbations in the ratio of T helper cell phenotypes; rather, it reflected a defect in antigen-presenting cells or in the islet beta cell targets.
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[Bible. A.T. (hébreu-français). 1831-1851]
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[Bible. A.T. (hébreu-français). 1831-1851]
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[Bible. A.T. (hébreu-français). 1831-1851]
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[Bible. A.T. (hébreu-français). 1831-1851]
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[Bible. A.T. (hébreu-français). 1831-1851]
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[Bible. A.T. (hébreu-français). 1831-1851]
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[Bible. A.T. (hébreu-français). 1831-1851]
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[Bible. A.T. (hébreu-français). 1831-1851]
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[Bible. A.T. (hébreu-français). 1831-1851]
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An analysis of the performance of GDP, employment and otherlabor market variables following the troughs in postwar U.S. businesscycles points to much slower recoveries in the three most recentepisodes, but does not reveal any significant change over time in therelation between GDP and employment. This leads us to characterizethe last three episodes as slow recoveries, as opposed to jobless recoveries.We use the estimated New Keynesian model in Galí-Smets-Wouters (2011) to provide a structural interpretation for the slowerrecoveries since the early nineties.