Exploring Technology Evolution Using Patent Classification: A Case of Cochlear Implant Technology Patents

Understanding technology evolution through periodic landscaping is an important stage of strategic planning in R&D Management. In fields like that of healthcare, where the initial R&D investment is huge and good medical product serve patients better, these activities become crucial. Approximately five percentage of the world population has hearing disabilities. Current hearing aid products meet less than ten percent of the global needs. Patent data and classifications on cochlear implants from 1977-2010, show the landscapes and evolution in the area of such implant. We attempt to highlight emergence and disappearance of patent classes over period of time showing variations in cochlear implant technologies. A network analysis technique is used to explore and capture technology evolution in patent classes showing what emerged or disappeared over time. Dominant classes are identified. The sporadic influence of university research in cochlear implants is also discussed.

Unique Covering Problems with Geometric Sets

The Exact Cover problem takes a universe U of n elements, a family F of m subsets of U and a positive integer k, and decides whether there exists a subfamily(set cover) F' of size at most k such that each element is covered by exactly one set. The Unique Cover problem also takes the same input and decides whether there is a subfamily F' subset of F such that at least k of the elements F' covers are covered uniquely(by exactly one set). Both these problems are known to be NP-complete. In the parameterized setting, when parameterized by k, Exact Cover is W1]-hard. While Unique Cover is FPT under the same parameter, it is known to not admit a polynomial kernel under standard complexity-theoretic assumptions. In this paper, we investigate these two problems under the assumption that every set satisfies a given geometric property Pi. Specifically, we consider the universe to be a set of n points in a real space R-d, d being a positive integer. When d = 2 we consider the problem when. requires all sets to be unit squares or lines. When d > 2, we consider the problem where. requires all sets to be hyperplanes in R-d. These special versions of the problems are also known to be NP-complete. When parameterizing by k, the Unique Cover problem has a polynomial size kernel for all the above geometric versions. The Exact Cover problem turns out to be W1]-hard for squares, but FPT for lines and hyperplanes. Further, we also consider the Unique Set Cover problem, which takes the same input and decides whether there is a set cover which covers at least k elements uniquely. To the best of our knowledge, this is a new problem, and we show that it is NP-complete (even for the case of lines). In fact, the problem turns out to be W1]-hard in the abstract setting, when parameterized by k. However, when we restrict ourselves to the lines and hyperplanes versions, we obtain FPT algorithms.

Phytomedicinal importance of Saraca asoca (Ashoka): an exciting past, an emerging present and a promising future

Since the dawn of civilization, natural resources have remained the mainstay of various remedial approaches of humans vis-a-vis a large number of illnesses. Saraca asoca (Roxb.) de Wilde (Saraca indica L.) belonging to the family Caesalpiniaceae has been regarded as a universal panacea in old Indian Ayurvedic texts and has especially been used to manage gynaecological complications and infections besides treating haemmorhagic dysentery, uterine pain, bacterial infections, skin problems, tumours, worm infestations, cardiac and circulatory problems. Almost all parts of the plant are considered pharmacologically valuable. Extensive folkloric practices and ethnobotanical applications of this plant have even lead to the availability of several commercial S. asoca formulations recommended for different indications though adulteration of these remains a pressing concern. Though a wealth of knowledge on this plant is available in both the classical and modern literature, extensive research on its phytomedicinal worth using state-of-the-art tools and methodologies is lacking. Recent reports on bioprospecting of S. asoca endophytic fungi for industrial bioproducts and useful pharmacologically relevant metabolites provide a silver lining to uncover single molecular bio-effectors from its endophytes. Here, we describe socio-ethnobotanical usage, present the current pharmacological status and discuss potential bottlenecks in harnessing the proclaimed phytomedicinal worth of this prescribed Ayurvedic medicinal plant. Finally, we also look into the possible future of the drug discovery and pharmaceutical R&D efforts directed at exploring its pharma legacy.

Anuario Argentino de Derecho Canónico, 2007, Vol. XIV (número completo)

Contenido: La anorexia y la bulimia como causas psicopatológicas de nulidad matrimonial / C. Baccioli – El acuerdo de 1957 / R. Bosca – Algunas consideraciones acerca de las presunciones jurídicas : aportes de la filosofía del derecho canónico / A. D. Busso – Los nuevos movimientos eclesiales y su encuadramiento canónico en la Iglesia particular / M. D. Colombo – Las relaciones diplomáticas entre el gobierno argentino y la Santa Sede : notas históricas sobre un posible concordato (1853-1892) / J. G. Durán – Abusos sexuales cometidos por clérigos y admisión al Orden Sagrado ¿un problema de homosexualidad? / R. D. Medina – Obispos y sexualidad : los cánones de Elvira como instrumento de disciplinamiento social / S. Panzram – Requisitos de prueba, la exigencia de un mínimo de prueba y la notoriedad en el derecho procesal medieval (siglos IX-XII) / M. Schmoeckel – Algunas consideraciones alrededor del canon 221 / H. A. von Ustinov – Notas – Documentos – Sentencias – Actualidad – Recensiones

Validity ranges of interfacial wave theories in a two-layer fluid system

In the present paper, we endeavor to accomplish a diagram, which demarcates the validity ranges for interfacial wave theories in a two-layer system, to meet the needs of design in ocean engineering. On the basis of the available solutions of periodic and solitary waves, we propose a guideline as principle to identify the validity regions of the interfacial wave theories in terms of wave period T, wave height H, upper layer thickness d(1), and lower layer thickness d(2), instead of only one parameter-water depth d as in the water surface wave circumstance. The diagram proposed here happens to be Le Mehautes plot for free surface waves if water depth ratio r = d(1)/d(2) approaches to infinity and the upper layer water density rho(1) to zero. On the contrary, the diagram for water surface waves can be used for two-layer interfacial waves if gravity acceleration g in it is replaced by the reduced gravity defined in this study under the condition of sigma = (rho(2) - rho(1))/rho(2) -> 1.0 and r > 1.0. In the end, several figures of the validity ranges for various interfacial wave theories in the two-layer fluid are given and compared with the results for surface waves.