Nova mappa geographica Sueciae ac Gothiae regna ut et Finlandiae ducatum ac Lapponiam, cum provinciis minoribus, ob oculos ponens, cura et sumtibus Tobiae Conradi Lotter, chalcogr et geogr: Augustae Vindel.

Alareunassa privilegiomerkintä: Cum gratia et privil. s. r. i. vicariatq, in partibq Rheni, Sveviae, et juris Franconici.

Fons lacrymarum Sveo-Gothicae gentis, per theoriam solis ad d. April. 5 anni M.DC.XCVII

Jehovah auxiliante!

De Spiritu Sancto, et aeterna eius divinitate ac processione; nec non officio atque donis

Invokaatio: Sun to Theo trisbeltiso kai megiso.

Fasciculus physicae ejusdem illustriores definitiones, divisiones, atque nobiliores controversias axiomatibus nonnullis insertas brevibusque rationibus firmatas ac enodatas continens

Arkit: 4 arkintunnuksetonta lehteä, A-F8 G4.

Zetémata quaedam ex spatioso ac fructuoso philosophiae agro excerpta

Invokaatio: Cum Deo.

De theologiae natura, ad decretum venerandae facultatis theologicae, moderatore plurimum reverendo, amplissimo ac praeclarissimo dn. Abrahamo Thauvonio, s. s. theol. doctore & professore ord: p. t. magnifico rectore, boni ominis [!] causa, ante introductionem suam disputabit Petrus Bång Hels. In auditorio majore die 9. Decemb. anno 1665

Invokaatio: I.N.J.

Themata nonnulla theoretica simul ac practica duabus sectionibus inclusa

Invokaatio: Auxilio Jehovae.

Summa rerum genera esse tantum duo: substantiam nimirum & accidens, ex suffragio ampliss. facult. philos. in florentissimo ad Auram Athenaeo, sub umbone ... dn. mag. Simonis Tålpo, met & log. professoris famigeratissimi, consistorii Acad. assessoris gravissimi nec non annexae Pijkensis pastoris longe fidelissimi. Summos in philosophia honores aditurus dissertatione philosophica ad sobrie philosophantium examen modeste delata statuere conabitur Jeremias Wallenius J. f. Tavastensis. Ad diem 21. Nov. anni redempti orbis M. DC. XC. IV. Horis pomeridianis in auditorio maximo

Invokaatio: A.J.

Transcriptional regulation of bidirectional gene pairs by 17-β-estradiol in MCF-7 breast cancer cells

Using cDNA microarray analysis, we previously identified a set of differentially expressed genes in primary breast tumors based on the status of estrogen and progesterone receptors. In the present study, we performed an integrated computer-assisted and manual search of potential estrogen response element (ERE) binding sites in the promoter region of these genes to characterize their potential to be regulated by estrogen receptors (ER). Publicly available databases were used to annotate the position of these genes in the genome and to extract a 5’flanking region 2 kb upstream to 2 kb downstream of the transcription start site for transcription binding site analysis. The search for EREs and other binding sites was performed using several publicly available programs. Overall, approximately 40% of the genes analyzed were potentially able to be regulated by estrogen via ER. In addition, 17% of these genes are located very close to other genes organized in a head-to-head orientation with less than 1.0 kb between their transcript units, sharing a bidirectional promoter, and could be classified as bidirectional gene pairs. Using quantitative real-time PCR, we further investigated the effects of 17β-estradiol and antiestrogens on the expression of the bidirectional gene pairs in MCF-7 breast cancer cells. Our results showed that some of these gene pairs, such as TXNDC9/EIF5B, GALNS/TRAPPC2L, and SERINC1/PKIB, are modulated by 17β-estradiol via ER in MCF-7 breast cancer cells. Here, we also characterize the promoter region of potential ER-regulated genes and provide new information on the transcriptional regulation of bidirectional gene pairs.

Positiones philosophicae ex fragrantissimo philosophiae viridario carptìm collectae. Quas ex consensu amplissimae [et] venerandae facultatis philosophicae in Regiâ Academiâ Aboënsi. Sub praesidio, ... dn. Michaelis Gyllenstålpes, Wexionii, j. u. & philos: doct: pereximii, ll:m polit: & hist: prof: publ: celeberrimi, p. t. rectoris magnifici, moecenatis, praecept. ac promotoris quovis obsequii & honoris genere plurimùm prosequendi. Liberalis exercitij gratia, publicae eruditorum disquisitioni modestè sistit Daniel B. Rosander Smolandus s. r. m.tis stipendiarius. In auditorio majori ad diem 22. Novemb. anno 1654. Horis ab 8. antemeridianis

Variantti A.

De Sveo-Gothis; qui vixerunt sub periodo Erici I.mi. ad Ericum 2.dum: memorans quomodo restituti sunt primum ab Erico, mox tamen ac multos annos ab incertis ducibus vexati, at nunquam vera religione destituti

Variantti B.

De Sveo-Gothis; qui vixerunt sub periodo Erici I.mi. ad Ericum 2.dum: memorans quomodo restituti sunt primum ab Erico, mox tamen ac multos annos ab incertis ducibus vexati, at nunquam vera religione destituti

Variantti A.

De Sveo-Gothis, qvi vixerunt seculis post natum Christum, duobus primis: tradens fidei eorum articulos, ac conversorum nomina, sed cumprimis probans ecclesiae existentiam apud illos, seculo Christi secundo: docens item modum ejus tam propagatae in omnes provincias, quam auctae plurimum in provinciis cunctis

Variantti A.

Sanctus Ansgarius vulgo Svecorum Danorumque apostolus seu Vita Sancti Ansgarii olim â quodam pontificio latine scripta, ac postea ab alio in svecicum idioma translata: at hic rursus in latinum conversa, abbreviata et sobria censurâ theologicâ passim castigata, lucique publicae data

Invokaatio: I.N.J.

Co-culture of apoptotic breast cancer cells with immature dendritic cells: a novel approach for DC-based vaccination in breast cancer

A dendritic cell (DC)-based vaccine strategy could reduce the risk of recurrence and improve the survival of breast cancer patients. However, while therapy-induced apoptosis of hepatocellular and colorectal carcinoma cells can enhance maturation and antigen presentation of DCs, whether this effect occurs in breast cancer is currently unknown. In the present study, we investigated the effect of doxorubicin (ADM)-induced apoptotic MCF-7 breast cancer cells on the activation of DCs. ADM-induced apoptotic MCF-7 cells could effectively induce immature DC (iDC) maturation. The mean fluorescence intensity (MFI) of DC maturity marker CD83 was 23.3 in the ADM-induced apoptotic MCF-7 cell group compared with 8.5 in the MCF-7 cell group. The MFI of DC co-stimulatory marker CD86 and HLA-DR were also increased after iDCs were treated with ADM-induced apoptotic MCF-7 cells. Furthermore, the proliferating autologous T-lymphocytes increased from 14.2 to 40.3% after incubated with DCs induced by apoptotic MCF-7 cells. The secretion of interferon-γ by these T-lymphocytes was also increased. In addition, cell-cell interaction between apoptotic MCF-7 cells and iDCs, but not soluble factors released by apoptotic MCF-7 cells, was crucial for the maturation of iDCs. These findings constitute a novel in vitro DC-based vaccine strategy for the treatment of breast cancer by ADM-induced apoptotic MCF-7 cells.