A influência da ortografia na percepção e produção do inglês como língua estrangeira

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Proposta curricular do Estado de São Paulo: a relação entre as crenças e a prática de dois professores de inglês

Pós-graduação em Estudos Linguísticos - IBILCE

Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A(2A) receptors and redistribution of synaptic vesicles

The mechanisms underlying improvement of neuromuscular transmission deficits by glucocorticoids are still a matter of debate despite these compounds have been used for decades in the treatment of autoimmune myasthenic syndromes. Besides their immunosuppressive action, corticosteroids may directly facilitate transmitter release during high-frequency motor nerve activity. This effect coincides with the predominant adenosine A(2A) receptor tonus, which coordinates the interplay with other receptors (e.g. muscarinic) on motor nerve endings to sustain acetylcholine (ACh) release that is required to overcome tetanic neuromuscular depression in myasthenics. Using myographic recordings, measurements of evoked [H-3]ACh release and real-time video microscopy with the FM4-64 fluorescent dye, results show that tonic activation of facilitatory A(2A) receptors by endogenous adenosine accumulated during 50 Hz bursts delivered to the rat phrenic nerve is essential for methylprednisolone (03 mM)-induced transmitter release facilitation, because its effect was prevented by the A(2A) receptor antagonist, ZM 241385 (10 nM). Concurrent activation of the positive feedback loop operated by pirenzepine-sensitive muscarinic M-1 autoreceptors may also play a role, whereas the corticosteroid action is restrained by the activation of co-expressed inhibitory M-2 and Al receptors blocked by methoctramine (0.1 mu M) and DPCPX (2.5 nM), respectively. Inhibition of FM4-64 loading (endocytosis) by methylprednisolone following a brief tetanic stimulus (50 Hz for 5 s) suggests that it may negatively modulate synaptic vesicle turnover, thus increasing the release probability of newly recycled vesicles. Interestingly, bulk endocytosis was rehabilitated when methylprednisolone was co-applied with ZM241385. Data suggest that amplification of neuromuscular transmission by methylprednisolone may involve activation of presynaptic facilitatory adenosine A(2A) receptors by endogenous adenosine leading to synaptic vesicle redistribution. (C) 2014 Elsevier Ltd. All rights reserved.

Analysis of generalized interictal discharges using quantitative EEG

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Modulation of synaptic transmission in hippocampal CA1 neurons by a novel neurotoxin (beta-pompilidotoxin) derived from wasp venom

We examined the effects of beta-pompilidotoxin (beta-PMTX), a neurotoxin derived from wasp venom. on synaptic transmission in the mammalian central nervous system (CNS). Using hippocampal slice preparations of rodents, we made both extracellular and intracellular recordings from the CA1 pyramidal neurons in response to stimulation of the Schaffer collateral/commissural fibers. Application of 5-10 muM beta-PMTX enhanced excitatory postsynaptic potentials (EPSPs) but suppressed the fast component of the inhibitory postsynaptic potentials (IPSPs). In the presence of 10 muM bicuculline, beta-PMTX potentiated EPSPs that were composed of both non-NMDA and NMDA receptor-mediated potentials. Potentiation of EPSPs was originated by repetitive firings of the prosynaptic axons, causing Summation of EPSPs. In the presence of 10 muM CNQX and 50 muM APV, beta-PMTX suppressed GABA(A) receptor-mediated fast IPSPs but retained GABA(B) receptor-mediated slow IPSPs. Our results suggest that beta-PMTX facilitates excitatory synaptic transmission by a presynaptic mechanism and that it causes overexcitation followed by block of the activity of some population of interneurons which regulate the activity of GABA(A) receptors. (C) 2001 Published by Elsevier B.V. Ireland Ltd and the Japan Neuroscience Society.

Disintegration of magnetic tablets in human stomach evaluated by alternate current biosusceptometry

Oral administration is the most convenient route for drug therapy. The knowledge of the gastrointestinal transit and specific site for drug delivery is a prerequisite for development of dosage forms. The aim of this work was to demonstrate that is possible to monitor the disintegration process of film-coated magnetic tablets by multi-sensor alternate current Biosusceptometry (ACB) in vivo and in vitro. This method is based on the recording of signals produced by the magnetic tablet using a seven sensors array and signal-processing techniques. The disintegration was confirmed by signals analysis in healthy human volunteers' measurements and in vitro experiments. Results showed that ACB is efficient to characterize the disintegration of dosage forms in the stomach, being a research tool for the development of new pharmaceutical dosage forms.

Nasalance during use of pharyngeal and glottal place of production

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Alternate current biosusceptometry for the assessment of gastric motility after proximal gastrectomy in rats: a feasibility study

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Aplicação do sistema de biosusceptometria AC para monitoramento de nanopartículas magnéticas na circulação sanguínea

Pós-graduação em Biologia Geral e Aplicada - IBB

Material didático para alunos surdos: a literatura infantil em Libras

The storytelling is central to the early literacy of children, part of the objectives for the entire kindergarten. The story circle or storytelling is important and helpful in cognitive and emotional development of children, including the ones with disabilities. Seeking communicational accessibility, the aim of this work is to make the book "O Penuginha" by Luiz Vitor Martinello available in LIBRAS (Brazilian Sign Language). To facilitate the achievement of this objective, it was considered appropriate to develop a descriptive study following the methodology of qualitative research, to search for literature on how learning takes place in the Portuguese language by deaf students. This study resulted in a DVD with video recordings, the translation of the book "O Penuginha" in LIBRAS and the narration of the book in Portuguese. Therefore, this research is relevant because the paradigm of the twenty first century is the inclusion of all people in different scenarios and the school is one of the first places where the removal of barriers is essential.

Baixo desempenho e enriquecimento da interação: propostas de Feuerstein e mediação da aprendizagem

This text is the result of a larger study into the role of the mother tongue in the construction of school knowledge, with a view to promoting gains in the performance of teenagers. The three objectives in this particular paper are: (1) to address Feuerstein's ideas, how the mother tongue interrelates with specific content, and the management of pedagogical interaction; (2) to illustrate enriched interaction during interventions by the researcher; and (3) to point out that supervised internship actions may help underachieving students. This is done in light of an interpretive analysis of the specialized literature, course books, reports and notes concerning interventions with students, and video and audio recordings. The analysis of interactions and student output following the researcher's interventions reveals increased awareness and change regarding school knowledge and how speaking/writing about specific content may enhance their performance in the completion of pedagogical tasks.

The interactive whiteboard in primary school: a case study of a brazilian district school

Interactive whiteboards (IWB) consist of a set of technological equipment organized in order to fulfill a specific task, enabling the development of didactic activities. Because they are associated to computers’ potentiality, interactive whiteboards can provide bigger interactivity between: teacher and students, students and content, and among students. This work’s main objective is to present some of the results yielded from a research related to the way students perceive interactive whiteboards in the classroom. In order to analyze the IWB usage dynamics, some educational applications in the field of mathematics were applied in the 3rd grade of elementary school. Aside from observation, video recordings were made and students were interviewed about the interactive whiteboard, in order to understand how these students observe and engage with the technological tool. IWB do not transform classroom’s reality by themselves, however, their physical presence and usage amount to external reinforcement can change student’s behavior positively.

Língua portuguesa no ensino médio: repertórios de ensino no âmbito do programa São Paulo faz Escola

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Leitura na educação infantil: implicações da Teoria Histórico-Cultural

Pós-graduação em Educação - FFC

Relações entre gerações na dança e na educação: a coeducação em Memorial dos Ossos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)