Targeted cell elimination reveals an auxin-guided biphasic mode of lateral root initiation.

To sustain a lifelong ability to initiate organs, plants retain pools of undifferentiated cells with a preserved proliferation capacity. The root pericycle represents a unique tissue with conditional meristematic activity, and its tight control determines initiation of lateral organs. Here we show that the meristematic activity of the pericycle is constrained by the interaction with the adjacent endodermis. Release of these restraints by elimination of endodermal cells by single-cell ablation triggers the pericycle to re-enter the cell cycle. We found that endodermis removal substitutes for the phytohormone auxin-dependent initiation of the pericycle meristematic activity. However, auxin is indispensable to steer the cell division plane orientation of new organ-defining divisions. We propose a dual, spatiotemporally distinct role for auxin during lateral root initiation. In the endodermis, auxin releases constraints arising from cell-to-cell interactions that compromise the pericycle meristematic activity, whereas, in the pericycle, auxin defines the orientation of the cell division plane to initiate lateral roots.

La conservació-restauració en el préstec de Béns Culturals per a exposicions temporals. Recursos per sistematitzar la documentació i garantir les millors condicions per als Béns Culturals en trànsit

Com a resultat de les práctiques realitzades al Museu Nacional d'Art de Catalunya (MNAC), entrenovembre de 2010 i febrer de 2011, emmarcades dins del Practicum del Màster de Direcció de Projectes de Conservació Restauració (Facultat de Belles Arts, Universitat Barcelona) vaig entraren contacte amb l'activitat del préstec d'obres d'art per a exposicions temporals. L'interès que em va suscitar, juntament amb el desconeixement que tenia en la matèria, em van portar a dedicarel Treball Final de Master a la recerca deis diferents aspectes que envolten el préstec de Béns Culturals en exposicions temporals, començant per una visió més global i acabant de centrar laproposta en l'àmbit de la conservació-restauració (i especialment en l'activitat documental que requereix).El treball pretén demostrar que la sistematització d'aquesta documentació és una eina bàsica per a un bon desenvolupament del procés de préstec, i ho fa fixant-se especialment en la documentació que depen de l'Àrea de Conservació-Restauració que, al cap i a la fi, és la documentació que hade permetre neutralitzar els riscos que pot comportar el préstec per a la integritat de les obres en trànsit...

Compressive neuropathy of the first branch of the lateral plantar nerve: a study by magnetic resonance imaging

Abstract Objective: To assess the prevalence of isolated findings of abnormalities leading to entrapment of the lateral plantar nerve and respective branches in patients complaining of chronic heel pain, whose magnetic resonance imaging exams have showed complete selective fatty atrophy of the abductor digiti quinti muscle. Materials and Methods: Retrospective, analytical, and cross-sectional study. The authors selected magnetic resonance imaging of hindfoot of 90 patients with grade IV abductor digiti quinti muscle atrophy according to Goutallier and Bernageau classification. Patients presenting with minor degrees of fatty muscle degeneration (below grade IV) and those who had been operated on for nerve decompression were excluded. Results: A female prevalence (78.8%) was observed, and a strong correlation was found between fatty muscle atrophy and plantar fasciitis in 21.2%, and ankle varices, in 16.8% of the patients. Conclusion: Fatty atrophy of the abductor digiti quinti muscle is strongly associated with neuropathic alterations of the first branch of the lateral plantar nerve. The present study showed a significant association between plantar fasciitis and ankle varices with grade IV atrophy of the abductor digiti quinti muscle.

Lateral gene exchanges shape the genomes of amoeba-resisting microorganisms.

Based on Darwin's concept of the tree of life, vertical inheritance was thought to be dominant, and mutations, deletions, and duplication were streaming the genomes of living organisms. In the current genomic era, increasing data indicated that both vertical and lateral gene inheritance interact in space and time to trigger genome evolution, particularly among microorganisms sharing a given ecological niche. As a paradigm to their diversity and their survival in a variety of cell types, intracellular microorganisms, and notably intracellular bacteria, were considered as less prone to lateral genetic exchanges. Such specialized microorganisms generally have a smaller gene repertoire because they do rely on their host's factors for some basic regulatory and metabolic functions. Here we review events of lateral gene transfer (LGT) that illustrate the genetic exchanges among intra-amoebal microorganisms or between the microorganism and its amoebal host. We tentatively investigate the functions of laterally transferred genes in the light of the interaction with their host as they should confer a selective advantage and success to the amoeba-resisting microorganisms (ARMs).

Added value of SPECT/CT in addition to whole-body scintigraphy augmented with prone lateral views in patients with well-differentiated thyroid carcinoma

Purpose: We aimed to determine the impact of SPECT/CT performed in addition to whole-­‐body scintigraphy augmented with prone lateral views in patients with well-­‐differentiated thyroid carcinoma. Methods and Materials: This retrospective study included 141 patients (87 female, 54 male, mean age 47 years) with well-­‐differentiated thyroid carcinoma (105 papillary, 31 follicular, 1 Hürthle cell and 4 poorly differentiated) treated with radioiodine therapy (1000-7400 MBq). Patients were referred for either first postsurgical therapy (n=76) or further treatment (n=65). Two nuclear medicine physicians interpreted the scans in consensus (first whole-­‐body scintigraphy with prone lateral view, then SPECT/CT) reporting abnormal iodine uptake in the thyroid bed, lymph nodes and distant metastasis. The corresponding ATA risk score was calculated for each patient before and after SPECT/CT, as well as change in disease extension Results: The analysis showed a difference between scintigraphy and SPECT/CT in n=17 lesions in 14 patients (9.9%): 12 were described as suspicious on scintigraphy and could be considered as benign on SPECT/CT (3 corresponded to local iodine uptake, 6 to lymph nodes metastases and 3 to distant metastases). The others 5 corresponded to metastases (4 lymph nodes and 1 distant) that were not seen on whole-­‐body scintigraphy augmented with prone lateral views. In 10 of 141 (7.1%) patients, we observed a change in ATA risk stratification, with a risk increase in 4 of them (2.8%). Conclusion: SPECT/CT allowed detecting 5 focal lesions missed on planar scintigraphy, and to precise benignity of 12 suspicious lesions on planar scintigraphy. Moreover, SPECT/CT improved the risk stratification in 10 patients with a significant change in the patient management

Sobre la distribucio de Trifolium diffusum Ehrh. als Paisos Catalans

En aquesta nota aportem noves dades corològiques de Trifolium diffusum Ehrh. als Països Catalans i confi rmem la seva presència a Catalunya.

La conservació-restauració en el préstec de Béns Culturals per a exposicions temporals. Recursos per sistematitzar la documentació i garantir les millors condicions per als Béns Culturals en trànsit

Com a resultat de les práctiques realitzades al Museu Nacional d'Art de Catalunya (MNAC), entrenovembre de 2010 i febrer de 2011, emmarcades dins del Practicum del Màster de Direcció de Projectes de Conservació Restauració (Facultat de Belles Arts, Universitat Barcelona) vaig entraren contacte amb l'activitat del préstec d'obres d'art per a exposicions temporals. L'interès que em va suscitar, juntament amb el desconeixement que tenia en la matèria, em van portar a dedicarel Treball Final de Master a la recerca deis diferents aspectes que envolten el préstec de Béns Culturals en exposicions temporals, començant per una visió més global i acabant de centrar laproposta en l'àmbit de la conservació-restauració (i especialment en l'activitat documental que requereix).El treball pretén demostrar que la sistematització d'aquesta documentació és una eina bàsica per a un bon desenvolupament del procés de préstec, i ho fa fixant-se especialment en la documentació que depen de l'Àrea de Conservació-Restauració que, al cap i a la fi, és la documentació que hade permetre neutralitzar els riscos que pot comportar el préstec per a la integritat de les obres en trànsit...

Tuberous sclerosis complex with oral manifestations: A case report and literature review

Introduction: Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome produced by a number of genetic mutations. The disease is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas, gingival hyperplasia and enamel hypoplasia. Clinical Case: A 35-year-old woman diagnosed with TSC presented with a reactive fibroma of considerable size and rapid growth in the region of the right lower third molar. Discussion: In the present case the association of TSC with dental malpositioning gave rise to a rapidly evolving reactive fibroma of considerable diameter. Few similar cases can be found in the literature. Patients with TSC present mutations of the TSC1 and TSC2 genes, which intervene in cell cycle regulation and are important for avoiding neoplastic processes. No studies have been found associating TSC with an increased risk of oral cancer, though it has been shown that the over-expression of TSC2 could exert an antitumor effect. Careful oral and dental hygiene, together with regular visits to the dentist, are needed for the prevention and early detection of any type of oral lesion. The renal, pulmonary and cardiac alterations often seen in TSC must be taken into account for the correct management of these patients.

Lateral periodontal cysts: a retrospective study of 11 cases

Objective: To describe the clinical, radiological and histopathological features of lateral periodontal cysts among patients diagnosed in different centers (Vall d"Hebron General Hospital, Granollers General Hospital, the Teknon Medical Center, and the Master of Oral Surgery and Implantology of the University of Barcelona Dental School; Barcelona, Spain). Study design: A retrospective observational study was made of 11 lateral periodontal cysts, all of which were diagnosed following a thorough clinical examination, radiological study and posterior histological study. Results: The mean patient age was 37 years, and males predominated over females. The mean lesion size was 1.25 cm. A single relapse was recorded 7 years after removal of the initial lesion. All the cysts were surgically removed. Discussion and conclusions: Lateral periodontal cysts are very infrequent, and are characterized by the preserved vitality of the adjacent teeth. Identification of the lesion is initially based on the clinical findings, though histological study is required to confirm the diagnosis. The treatment of choice is the surgical removal, though occasional relapses have been documented

Validação lateral em relações quantitativas entre estrutura e atividade farmacológica, QSAR

The comparative QSAR is a tool for validating any statistical model that seems to be reasonable in describing an interaction between a bioactive new chemical entity, BIONCE, and the biological system. In order to deeper the understanding of the relationships and the meaning of parameters within the model it is necessary some kind of lateral validation. This validation can be accomplished by chemical procedures using physicochemical organic reactions and by means of biological systems. In this paper we review some of such comparisons and also present a lateral validation between the same set of antimicrobial hydrazides acting against Saccharomyces cerevisiae yeast and Escherichia coli bacterium cells. QSARs are presented to shed light in this important way of stating that the QSAR model is not the endpoint, but the beginning.

Fontcuberta i Famadas, Cristina. 'Imatges d'atac. Art i conflicte als segles XVI i XVII'

Durant els darrers anys hem assistit a una ampliació de la perspectiva a través de la qual han estat observades les imatges. Entre els historiadors de l'art, les preguntes tradicionals, centrades en l'autoria o en la seva dimensió estètica, han passat a compartir l'interès amb altres qüestions com ara la del comitent i el seu entorn, la circulació, el mercat o els múltiples usos i significats que aquelles podien adquirir.

La Gestió per competències als llocs de treball de comandament de les policies locals

Les policies són potser un dels sectors de l’administració que més incidència directa té sobre la ciutadania en les seves decisions quotidianes i que, per tant, més han d’evolucionar cap aquests models descentralitzats i horitzontals de decisió i de funcionament en xarxa. Aquesta responsabilitat de millora i adaptació és competència immediata dels comandaments intermedis i als Caps d’aquests Cossos, que hauran de disposar de les capacitats, habilitats i coneixements necessaris (competències) per dur-los a terme. Caldria, doncs, plantejar-nos si un sistema basat en la gestió per competències podria ser idoni per ser aplicat de forma integral: des del reclutament o selecció passant per la definició de perfils competencials per als llocs de treball, per posteriorment poder fer l’avaluació d’acompliment del lloc i atribuir en aquest resultat alguna mena de recompensa o reconeixement en forma de carrera professional vertical o horitzontal. En aquest treball ens centrarem en les dues primeres etapes, és a dir, estudiarem si la gestió per competències podria millorar els mètodes de reclutament i, de forma especial, en la definició del perfil professional idoni, per als Caps i els comandaments intermedis de la Policia Local, per a la qual cosa es durà a terme un treball de camp amb els responsables polítics i comandaments de diferents policies locals de Catalunya.