996 resultados para 7140-234
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M. Hieber, I. Wood: Asymptotics of perturbations to the wave equation. In: Evolution Equations, Lecture Notes in Pure and Appl. Math., 234, Marcel Dekker, (2003), 243-252.
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Gilmore, A.; Gallagher, D.; and Henry, S. (2007). E-marketing and SMEs: Operational lessons for the future. European Business Review. 19(3), pp.234-247 RAE2008
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O'Malley, T. (2007). Typically Anti-American?: The Labour movement, America and Broadcasting in Britain from Beveridge to Pilkington, 1949-62. In J. Wiener and M. Hampton (Eds.), Anglo- American Media Interactions,1850-2000 (pp.234-253). Basingstoke: Palgrave Macmillan. RAE2008
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Książka podzielona została na cztery części. W każdej z nich znajdują się teksty ukazujące inną stronę badań miasta wynikających z odmiennych perspektyw badawczych prezentowanych przez nasz interdyscyplinarny zespół badaczy. Książka dofinansowana ze środków: Prof. dr hab. Jacka Witkosia, prorektora Uniwersytetu im. Adama Mickiewicza w Poznaniu ds. nauki i współpracy międzynarodowej Prof. dr hab. Hanny Kóčki-Krenz, dziekan Wydziału Historycznego Prof. dr hab. Michała Buchowskiego, dyrektora Instytutu Etnologii i Antropologii Kulturowej
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13 hojas : ilustraciones, fotografías
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Poor oxygenation (hypoxia) is a common characteristic of human solid tumours, and is associated with cell survival, metastasis and resistance to radio- and chemotherapies. Hypoxia-induced stabilisation of hypoxia-inducible factor-1α (HIF-1α) leads to changes in expression of various genes associated with growth, vascularisation and metabolism. However whether HIF-1α plays a causal role in promoting hypoxic resistance to antitumour therapies remains unclear. In this study we used pharmacological and genetic methods to investigate the HIF-1α contribution to radio- and chemoresistance in four cancer cell lines derived from cervical, breast, prostate and melanoma human tumours. Under normoxia or hypoxia (<0.2% or 0.5% oxygen) the cells were exposed to either a standard irradiation dose (6.2 Gy) or chemotherapeutic drug (cisplatin), and subsequent cell proliferation (after 7 days) was measured in terms of resazurin reduction. Oxygen-dependent radio- and chemosensitivity was evident in all wild type whereas it was reduced or abolished in HIF-1α (siRNA) knockdown cells. The effects of HIF-1α-modulating drugs (EDHB, CoCl2, deferoxamine to stabilise and R59949 to destabilise it) reflected both HIF-1α-dependent and independent mechanisms. Collectively the data show that HIF-1α played a causal role in our in vitro model of hypoxia-induced radioresistance whereas its contribution to oxygendependent sensitivity to cisplatin was less clear-cut. Although this behavior is likely to be conditioned by further biological and physical factors operating in vivo, it is consistent with the hypothesis that interventions directed at HIF-1α may improve the clinical effectiveness of tumour treatments.
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Urban areas in many developing countries are expanding rapidly by incorporating nearby subsistence farming communities. This has a direct effect on the consumption and production behaviours of the farm households but empirical evidence is sparse. This thesis investigated the effects of rapid urbanization and the associated policies on welfare of subsistence farm households in peri-urban areas using a panel dataset from Tigray, Ethiopia. The study revealed a number of important issues emerging with the rapid urban expansion. Firstly, private asset holdings and consumption expenditure of farm households, that have been incorporated into urban administration, has decreased. Secondly, factors that influence the farm households’ welfare and vulnerability depend on the administration they belong to, urban or rural. Gender and literacy of the household head have significant roles for the urban farm households to fall back into and/or move out of poverty. However, livestock holding and share of farm income are the most important factors for rural households. Thirdly, the study discloses that farming continues to be important source of income and income diversification is the principal strategy. Participation in nonfarm employment is less for farm households in urban than rural areas. Adult labour, size of the local market and past experience in the nonfarm sector improves the likelihood of engaging in skilled nonfarm employment opportunities. But money, given as compensation for the land taken away, is not crucial for the household to engage in better paying nonfarm employments. Production behaviour of the better-off farm households is the same, regardless of the administration they belong to. However, the urban poor participate less in nonfarm employment compared to the rural poor. These findings signify the gradual development of urban-induced poverty in peri-urban areas. In the case of labour poor households, introducing urban safety net programmes could improve asset productivity and provide further protection.
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Measuring the entorhinal cortex (ERC) is challenging due to lateral border discrimination from the perirhinal cortex. From a sample of 39 nondemented older adults who completed volumetric image scans and verbal memory indices, we examined reliability and validity concerns for three ERC protocols with different lateral boundary guidelines (i.e., Goncharova, Dickerson, Stoub, & deToledo-Morrell, 2001; Honeycutt et al., 1998; Insausti et al., 1998). We used three novice raters to assess inter-rater reliability on a subset of scans (216 total ERCs), with the entire dataset measured by one rater with strong intra-rater reliability on each technique (234 total ERCs). We found moderate to strong inter-rater reliability for two techniques with consistent ERC lateral boundary endpoints (Goncharova, Honeycutt), with negligible to moderate reliability for the technique requiring consideration of collateral sulcal depth (Insausti). Left ERC and story memory associations were moderate and positive for two techniques designed to exclude the perirhinal cortex (Insausti, Goncharova), with the Insausti technique continuing to explain 10% of memory score variance after additionally controlling for depression symptom severity. Right ERC-story memory associations were nonexistent after excluding an outlier. Researchers are encouraged to consider challenges of rater training for ERC techniques and how lateral boundary endpoints may impact structure-function associations.
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Lower Extremity Joint Arthroplasty (LEJA) surgery is an effective way to alleviate painful osteoarthritis. Unfortunately, these surgeries do not normalize the loading asymmetry during the single leg stance phase of gait. Therefore, we examined single leg balance in 234 TJA patients (75 hips, 65 knees, 94 ankles) approximately 12 months following surgery. Patients passed if they maintained single leg balance for 10s with their eyes open. Patients one year following total hip arthroplasty (THA-63%) and total knee arthroplasty (TKA-69%) had similar pass rates compared to a total ankle arthroplasty (TAA-9%). Patients following THA and TKA exhibit better unilateral balance in comparison with TAA patients. It may be beneficial to include a rigorous proprioception and balance training program in TAA patients to optimize functional outcomes.
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Relatives to Planetary Nebulae, such as barium stars or symbiotic systems, can shed light on the connection between Planetary Nebulae and binarity. Because of the observational selection effects against direct spectroscopic detection of binary PNe cores with orbital periods longer than a few dozen days, at present these "awkward relatives" are a critical source of our knowledge about the binary PNe population at longer periods. Below a few examples are discussed, posing constraints on the attempts to model nebula, ejection process in a binary. © 2006 International Astronomical Union.
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Dentro de la inmensa gama de recursos naturales identificamos en la ciudad de Abancay - Perú al cuy (Cavia cobayo). Actualmente, se incentiva su producción y crianza en forma masiva por parte de los gobiernos locales, regionales y ONGs, que buscan en un corto y mediano plazo la exportación de estos roedores. Su carne se presenta en diferentes formas: embutidos de cuy, envasados al vacío fresco y otras presentaciones. La ciudad de Abancay se ha constituido como uno de los importantes productores de carne de cuy en el departamento de Apurímac y cuenta con un enorme potencial por sus condiciones climáticas y sociales, por ello se estableció como mercado objetivo a los consumidores de Abancay ubicados en el departamento de Apurímac-Perú con una demanda potencial de 121.524 unidades al año. Las estrategias de marketing para el posicionamiento de la carne de cuy empacada al vacío en Abancay-Perú de la Empresa Embutidos San Juan, fueron basados en el Estudio de Mercado de Carne de Cuy en el departamento de Apurímac - Perú realizado por la ONG Copyme, la segmentación se basó en variables geográficas (Censo-INEI, 2007), psicográficas (donde se determinó la falta de costumbre de consumo de carne de cuy) y demográficas (frecuencia de compra en relación al nivel de ingreso, los consumidores con mayor frecuencia de compra pertenecen a los que tienen ingresos menores de USD 234), el posicionamiento en base a la marca y al lema `Una tradición para compartir en familia` pretende entrar a la mente de los consumidores asociando las costumbres y la tradición con el sabor exquisito y la naturalidad del producto, apartando a los consumidores de la idea errónea de confundirlo con rata.
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p.229-234
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p.229-234
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Ya hace unos años A.K. Dewdney en su libro 200% de nada, se hacia eco de los curiosos usos sociales de los números donde se exagera la precisión de los mismos, en casos donde no tiene sentido (1.234.567 manifestantes, 345.674 peces en el lago, 14 horas 45 minutos 34 segundos andan- do,...), con vistas a dar una versión “mas científica” de la información que se desea transmitir. A este fenómeno lo bautizó Dewdney como “dramadigits”. Una conocida historia de John Allen Paulos es la del vigilante de un museo de ciencias naturales que estando ante un gran esqueleto de dinosaurio fue preguntado por unos visitantes sobre la antigüedad de aquellos restos y contestó con una sorprendente precisión: “90.000.006 años”. Extrañados los visitantes sobre los 6 años pidieron explicaciones al paciente guarda y éste respondió “cuando llegué aquí me dijeron que el dinosaurio tenia 90.000.000 de años y de esto ya hace 6 años”. En este clip me gustaría compartir algunas historias cuyo común denominador es este extraño sentido de la precisión.
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La comisión permanente del comité español del año mundial de las matemáticas 2000 reflexiona sobre el significado de las Matemáticas y su situación actual en España, así como sobre lo que ha supuesto la celebración de este año.