995 resultados para 1995_03232300 TM-33 4501306


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Welsch (Projektbearbeiter): Verurteilung des ehemaligen Versicherungsagenten Padovani (in Umwandlung einer zuvor ausgesprochenen Todesstrafe) zu zwölfjähriger Festungshaft wegen Aufruhrs

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Welsch (Projektbearbeiter): Verurteilung des Handelsagenten Ravaux (Raveaux?), des Buchbinders Schöninger sowie des ehemaligen preußischen Leutnants von Alvensleben (in Umwandlung der zuvor ausgesprochenen Todesstrafe) zu dreijähriger bzw. (im Falle von Alvenslebens) einjähriger Festungshaft wegen bewaffneten Widerstands gegen das Militär

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Welsch (Projektbearbeiter): Starke ungarische Verbände zwischen Gyöngyös und Hatvan; Gefechte bei Tápió-Bicske und Hatvan

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Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood. Interleukin (IL)-33 signaling plays a role in intestinal inflammation, yet its contribution to the pathogenesis of CRC is unknown. Using immunohistochemistry on 713 resected human CRC specimens, we show here that IL-33 and its receptor ST2 are expressed in low-grade and early-stage human CRCs, and to a lesser extent in higher-grade and more advanced-stage tumors. In a mouse model of CRC, ST2-deficiency protects from tumor development. Moreover, bone marrow (BM) chimera studies indicate that engagement of the IL-33/ST2 pathway on both the radio-resistant and radio-sensitive compartment is essential for CRC development. Mechanistically, activation of IL-33/ST2 signaling compromises the integrity of the intestinal barrier and triggers the production of pro-tumorigenic IL-6 by immune cells. Together, this data reveals a tumor-promoting role of IL-33/ST2 signaling in CRC.

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Siegfried Ucko

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Trägerband: Inc. oct. 361; Vorbesitzer: Dominikanerkloster Frankfurt am Main

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G. Marcus

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Vorbesitzer: Bartholomaeusstift Frankfurt am Main