Report on a special investigation of the Monona County Auditor’s Office for the period January 1, 2011 through December 31, 2013

Report on a special investigation of the Monona County Auditor’s Office for the period January 1, 2011 through December 31, 2013

Special investigation of the City of West Liberty for the period July 1, 2010 through January 31, 2014

Special investigation of the City of West Liberty for the period July 1, 2010 through January 31, 2014

Special investigation of the Iowa County Treasurer’s Office for the period January 1, 2005 through June 30, 2011

Special investigation of the Iowa County Treasurer’s Office for the period January 1, 2005 through June 30, 2011

Special investigation of the Sac County Treasurer’s Office Motor Vehicle Department for the period January 1, 2010 through February 27, 2014

Special investigation of the Sac County Treasurer’s Office Motor Vehicle Department for the period January 1, 2010 through February 27, 2014

Emerging functions of myelin associated proteins during development neuronal plasticity and and neurpdegeneration.

Adult mammalian central nervous system (CNS) axons have a limited regrowth capacity following injury. Myelin-associated inhibitors (MAIs) limit axonal outgrowth and their blockage improves the regeneration of damaged fiber tracts. Three of these proteins, Nogo-A, MAG and OMgp, share two common neuronal receptors: NgR1, together with its co-receptors (p75(NTR), TROY and Lingo-1), and the recently described paired immunoglobulin-like receptor B (PirB). These proteins impair neuronal regeneration by limiting axonal sprouting. Some of the elements involved in the myelin inhibitory pathways may still be unknown, but the discovery that blocking both PirB and NgR1 activities leads to near-complete release from myelin inhibition, sheds light on one of the most competitive and intense fields of neuroregeneration study during in recent decades. In parallel with the identification and characterization of the roles and functions of these inhibitory molecules in axonal regeneration, data gathered in the field strongly suggest that most of these proteins have roles other than axonal growth inhibition. The discovery of a new group of interacting partners for myelin-associated receptors and ligands, as well as functional studies within or outside the CNS environment, highlights the potential new physiological roles for these proteins in processes such as development, neuronal homeostasis, plasticity and neurodegeneration.

What's so special about conversion disorder? A problem and a proposal for diagnostic classification.

Conversion disorder presents a problem for the revisions of DSM-IV and ICD-10, for reasons that are informative about the difficulties of psychiatric classification more generally. Giving up criteria based on psychological aetiology may be a painful sacrifice but it is still the right thing to do.

Report on a special investigation of the Martensdale-St. Marys Community School District for the period July 1, 2009 through April 30, 2014

Report on a special investigation of the Martensdale-St. Marys Community School District for the period July 1, 2009 through April 30, 2014

Report on a special investigation of the Mid-Prairie Community School District for the period July 1, 2012 through June 30, 2014

Report on a special investigation of the Mid-Prairie Community School District for the period July 1, 2012 through June 30, 2014

Report on a special investigation of the University of Northern Iowa International Dance Theatre for the period December 1, 2005 through February 28, 2014

Report on a special investigation of the University of Northern Iowa International Dance Theatre for the period December 1, 2005 through February 28, 2014

Report on a special investigation of Café DMACC within Des Moines Area Community College campus in Ankeny, Iowa for the period January 4, 2013 through May 2, 2014

Report on a special investigation of Café DMACC within Des Moines Area Community College campus in Ankeny, Iowa for the period January 4, 2013 through May 2, 2014

Traces of functions in Fock spaces on lattices of critical density

Following a scheme of Levin we describe the values that functions in Fock spaces take on lattices of critical density in terms of both the size of the values and a cancelation condition that involves discrete versions of the Cauchy and Beurling-Ahlfors transforms.

The White Cane Magazine, Special Edition 2014

Quarterly newsletter produced by the Iowa Department of Blind, about the information and activities that are on going in the department.

Uniform estimates in the Poincare-Aronszajn theorem on the separation of singularities of analytic functions

We study the possibility of splitting any bounded analytic function $f$ with singularities in a closed set $E\cup F$ as a sum of two bounded analytic functions with singularities in $E$ and $F$ respectively. We obtain some results under geometric restrictions on the sets $E$ and $F$ and we provide some examples showing the sharpness of the positive results.

Report on a special investigation of the City of Vining for the period May 1, 2008 through May 31, 2014

Report on a special investigation of the City of Vining for the period May 1, 2008 through May 31, 2014

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver.

Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic physiology across most living organisms. Although such rhythms have been extensively studied at the level of transcription and mRNA accumulation, little is known about the accumulation patterns of proteins. Here, we quantified temporal profiles in the murine hepatic proteome under physiological light-dark conditions using stable isotope labeling by amino acids quantitative MS. Our analysis identified over 5,000 proteins, of which several hundred showed robust diurnal oscillations with peak phases enriched in the morning and during the night and related to core hepatic physiological functions. Combined mathematical modeling of temporal protein and mRNA profiles indicated that proteins accumulate with reduced amplitudes and significant delays, consistent with protein half-life data. Moreover, a group comprising about one-half of the rhythmic proteins showed no corresponding rhythmic mRNAs, indicating significant translational or posttranslational diurnal control. Such rhythms were highly enriched in secreted proteins accumulating tightly during the night. Also, these rhythms persisted in clock-deficient animals subjected to rhythmic feeding, suggesting that food-related entrainment signals influence rhythms in circulating plasma factors.