977 resultados para electron paramagnetic resonance (EPR)
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Dissertação para obtenção do Grau de Doutor em Engenharia Biomédica
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Background : The neonatal arterial switch operation (ASO) is now the standard of care for children born with transposition of the great arteries. Stenosis of the neopulmonary artery on long‑term follow up is a known complication. Methods : We performed a retrospective analysis of eleven patients who underwent a cardiac magnetic resonance imaging (MRI) due to echocardiographic evidence suggestive of stenosis of the neopulmonary artery or its branches (mean estimated Doppler gradient 48 mmHg, min 30 mmHg, max 70 mmHg). A comprehensive evaluation of anatomy and perfusion was done by cardiac MRI. Results : The branches of the neopulmonary artery (neo PA) showed decreased caliber in three patients unilaterally and in two patients, bilaterally. Magnetic resonance (MR) perfusion studies showed concomitant decreased flow, with discrepancy between the two lungs of 35/65% or worse, only in the three patients with unilateral obstruction, by two different MR perfusion methods. Conclusions : Cardiac MR can be used as a comprehensive non‑invasive imaging technique to diagnose stenosis of the branches of the neopulmonary after the ASO, allowing evaluation of anatomy and function of the neoPA, its branches, and the differential perfusion to each lung, thus facilitating clinical decision making.
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Based on the report for “Project IV” unit of the PhD programme on Technology Assessment (Doctoral Conference) at Universidade Nova de Lisboa (December 2011). This thesis research has the supervision of António Moniz (FCT-UNL and ITAS-KIT) and Michael Decker (Karlsruhe Institute of Technology-ITAS). Other members of the thesis committee are Carlos Alberto da Silva (University of Évora), José Maria de Albuquerque (Institute of Welding and Quality), Lotte Steuten (University of Twente), Mário Forjaz Secca (FCT-UNL) and Nelson Chibeles Martins (FCT-UNL).
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Based on the report for the unit “Project III” of the PhD programme on Technology Assessment in 2011. The unit was supervised by Prof. António B. Moniz (FCT-UNL).
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J Biol Inorg Chem (2011) 16:1241–1254 DOI 10.1007/s00775-011-0812-9
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Biochem. J. (2011) 438,485–494 doi:10.1042/BJ20110836
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J Biol Inorg Chem (2011) 16:881–888 DOI 10.1007/s00775-011-0785-8
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Biochemistry, 2011, 50 (20), pp 4251–4262 DOI: 10.1021/bi101605p
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J Biol Inorg Chem (2010) 15:409–420 DOI 10.1007/s00775-009-0613-6
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J. Am. Chem. Soc., 2009, 131 (23), pp 7990–7998 DOI: 10.1021/ja809448r
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J Biol Inorg Chem (2007) 12:691–698 DOI 10.1007/s00775-007-0219-9
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J Biol Inorg Chem (2006) 11: 433–444 DOI 10.1007/s00775-006-0090-0
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J Biol Inorg Chem (2004) 9: 839–849 DOI 10.1007/s00775-004-0584-6