New synthetic methodologies from biorenewable resources

Tese de doutoramento, Farmácia (Química Farmacêutica e Terapêutica), Universidade de Lisboa, Faculdade de Farmácia, 2014

Design e auto-produção : novos paradigmas para o design de artefactos na sociedade pós-industrial : a contribuição das tecnologias digitais

Tese de doutoramento, Belas-Artes (Design de Equipamento), Universidade de Lisboa, Faculdade de Belas-Artes, 2015

The "Eco" and "Low-carbon" promise: a critical review of China's experience

The scale and speed of China’s urbanization translate into major challenges for sustainability. Could the ‘eco-city’ and ‘low-carbon’ agendas, and the promotion of related pilot cities drive Chinese urban practice towards more environmentally sustainable solutions? We explore this question through a critical review of experience in China, identifying problems relating to the development of space, the treatment of scale and the pursuit of efficiency (the ‘space-scale-efficiency nexus’). China seeks sustainable solutions through eco and low-carbon agendas, but our review finds that current efforts fall short of expectations, and problematic patterns are repeated. We propose that a geo-administrative notion of functional regions could provide a strategic framework to address the range of design, physical and administrative planning problems, ensuring that eco-city and low-carbon city pilots result in comprehensive solutions that can be effectively replicated.

The Development of Environmental Assessment Tools to Support the Creation of Dementia Friendly Care Environments: Innovative Practice

The need for more dementia friendly design in hospitals and other care settings is now widely acknowledged. Working with 26 NHS Trusts in England as part of a Department of Health commissioned programme, The King’s Fund developed a set of overarching design principles and an environmental assessment tool for hospital wards in 2012. Following requests from other sectors, additional tools were developed for hospitals, care homes, health centres and housing with care. The tools have proven to be effective in both disseminating the principles of dementia friendly design and in enabling the case to be made for improvements that have a positive effect on patient outcomes and staff morale. This paper reports on the development,use and review of the environmental assessment tools, including further work that is now being taken forward by The Association for Dementia Studies, University of Worcester.

Development of user-friendly, high throughput screening for ligands and inhibitors of carbohydrate modifying enzymes

This paper describes the impact of cloud computing and the use of GPUs on the performance of Autodock and Gromacs respectively. Cloud computing was applicable to reducing the ‘‘tail’’ seen in running Autodock on desktop grids and the GPU version of Gromacs showed significant improvement over the CPU version. A large (200,000 compounds) library of small molecules, seven sialic acid analogues of the putative substrate and 8000 sugar molecules were converted into pdbqt format and used to interrogate the Trichomonas vaginalis neuraminidase using Autodock Vina. Good binding energy was noted for some of the small molecules (~-9 kcal/mol), but the sugars bound with affinity of less than -7.6 kcal/mol. The screening of the sugar library resulted in a ‘‘top hit’’ with a-2,3-sialyllacto-N-fucopentaose III, a derivative of the sialyl Lewisx structure and a known substrate of the enzyme. Indeed in the top 100 hits 8 were related to this structure. A comparison of Autodock Vina and Autodock 4.2 was made for the high affinity small molecules and in some cases the results were superimposable whereas in others, the match was less good. The validation of this work will require extensive ‘‘wet lab’’ work to determine the utility of the workflow in the prediction of potential enzyme inhibitors.

Eco city development in China: addressing the policy implementation challenge

Over the last few decades, China has seen a steep rise in diverse eco city and low carbon city policies. Recently, attention has begun to focus on the perceived shortcomings in the practical delivery of related initiatives, with several publications suggesting a gap between ambitious policy goals and the emerging realities of the newly built environment. To probe this further, in this article we examine – based on the policy network approach – how the gap between high-level national policies and local practice implementation can be explained in the current Chinese context. We develop a four-pronged typology of eco city projects based on differential involvement of key (policy) actor groups, followed by a mapping of what are salient policy network relations among these actors in each type. Our analysis suggests that, within the overall framework of national policy, a core axis in the network relations is that between local government and land developers. In some cases, central government agencies– often with buy-in from international architecture, engineering and consulting firms – seek to influence local government planning through various incentives aimed at rendering sustainability a serious consideration. However, this is mostly done in a top-down manner, which overemphasizes a rational, technocratic planning mode while underemphasizing interrelationships among actors. This makes the emergence of a substantial implementation gap in eco city practice an almost predictable outcome. Consequently, we argue that special attention be paid in particular to the close interdependency between the interests of local government actors and those of land and real estate developers. Factoring in this aspect of the policy network is essential if eco city implementation is to gain proper traction on the ground.

Eco-cities: technological showcases or public spaces?

A growing body of critical literature seeks to identify conceptual and practical problems accompanying the realisation of mainstream ‘eco-city’ initiatives around the world. However, little attention has been paid to the status of the ‘city’ itself within the broader discourse. If eco-cities are to be more than experimental ‘technological showcases’, and aim to transform urban life more generally, the question of what types of ‘cityness’ will ensue is of considerable importance. To effect a more significant sustainability transition, eco-city plans and policies may need somehow to encompass a more nuanced conceptualisation of cities as complex, unpredictable, and emergent spaces. The incompatibility of such a conceptualisation with liberal-modernist modes of planning means that radically innovative new approaches to eco-city development may need to be found. This thesis considers whether the eco-city, theorised as a multiple process of real-world experimentation, may shed some light on how ‘cityness’ might better be planned for in future. To do so, it conceptualises cityness through the lens of ‘publicness’. It makes an original contribution to knowledge by developing a new theoretical model of publicness as an ‘assemblage’ of space and behaviour, with an ‘emergent’ and ‘civic’ modality. It thereby extends recent debates over the idea of ‘urban assemblage’, and makes innovative links between theories of planning and of the public. This model informs the analysis of original empirical research, investigating the conceptualisation of the public in an international sample of official eco-city documents, and exploring the publicness of two implemented initiatives, in Portland, Oregon (US) and newly built Sejong City (South Korea). The research finds that publicness tends to be poorly articulated in mainstream eco-city plans and policies, with potentially negative implications for sustainability in the ‘urban age’. However, it also argues that state institution-led planning – even when experimental ‘governance’ approaches are adopted – may inevitably be limited in its ability to encompass the emergent public life of the city. The thesis concludes by considering the prospects for overcoming or more productively acknowledging these limits in future.

Produto Aquaoli: projeto de design industrial em aquariofilia

Esta dissertação de mestrado, apresenta a elaboração de um projeto de design industrial em aquariofilia - Aquaoli. Pretende-se criar uma nova tipologia de aquários inovadora e distinta, projetando o produto com o intuito deste cumprir com todos os parâmetros exigidos pelo mercado e produção do mesmo. Definiu-se a criança entre os 7 e os 11 anos como público-alvo deste projeto. Assim, pretende-se um resultando promissor para a empresa AQUATLANTIS apostar e lucrar com o seu desenvolvimento. Para que este projeto obtivesse bons resultados, foi realizada uma pesquisa aprofundada, desde a aquariofilia (a sua história, biologia e mercado), do aquariófilo atual (psicologia do consumidor e as suas responsabilidades), até ao estado da arte (da AQUATLANTIS e dos produtos existentes no mercado). Este projeto foi desenvolvido em várias vertentes de design, procurando ser o mais completo possível. Isso foi viável com o desenvolvimento do produto e de todos os seus componentes em três dimensões, o desenvolvimento de maquetes e de protótipos do produto, o desenvolvimento do packaging e campanha promocional, a definição de preço custo e métodos de produção dos objetos, entre outros parâmetros. Obteve-se um projeto de design industrial bastante completo e com potencial para ser implementado no mercado, cativando a atenção do público-alvo e obtendo vendas elevadas. O aquário apresenta-se distinto dos existentes, principalmente no facto de ser modular, muito interativo, pedagógico e incorporar uma estrutura invulgar e particularmente cativante para as crianças. Este produto subdivide-se em dois conjuntos vendidos separadamente (Aquarium Pack e Kit-1 Pack), apresentando assim uma estratégia de marketing que pretende que a criança que o adquira pela primeira vez, venha a desejar adquirir mais produtos desta gama, procurando aumentar a sua estante e/ou o número de aquários e animais que incorpora na mesma.

Concepção e implementação do time-driven activity based costing numa PME industrial: evidência de um estudo empírico

Dissertação para obtenção do Grau de Mestre em Contabilidade e Finanças Orientador: Mestre Paulino Manuel Leite da Silva

Desperdícios na cadeia logística no âmbito industrial

Projecto apresentado ao Instituto Politécnico do Porto para obtenção do Grau de Mestre em Logística Orientada por Prof. Doutor Gouveia

Projecto dum laboratório remoto para automação de processos industriais

Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Mecânica

Sistemas de automação e manutenção de edifícios: concepção dos sistemas de detecção e protecção contra incêndios de uma unidade industrial

Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Mecânica

A engenharia Civil e a produção industrial de energia eólica

Dissertação para obtenção do grau de Engenharia Civil na Área de Especialização de Edificações

Construção de um parque eólico industrial

Dissertação de Natureza Científica para obtenção do grau de Mestre em Engenharia Civil na Área de Especialização de Edificações

Análise dos modos de falha e seus efeitos (FMEA) aplicada a um secador industrial

Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Mecânica