Electrochemical, Spectrophotometric and Liquid-Chromatographic Approaches for Analysis of Tropical Disease Drugs

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Lições de coisas: concepção científica e projeto modernizador para a sociedade

O objetivo deste artigo é compreender alguns aspectos da cultura escolar, assinalando a seleção de valores culturais, econômicos e educacionais operada pela instrução escolar, com base na análise de manuais didáticos para uso de professores, elaborados nas décadas finais do século XIX e fundamentados no Método de Ensino Intuitivo ou Lições de Coisas. Embora expressem a mesma fundamentação filosófica, os manuais apresentam diferentes procedimentos para o ensino dos conteúdos escolares que se configuram como visões específicas do progresso científico. Vinculados ao projeto modernizador da sociedade, em curso no século XIX, as diferenças apresentadas pelos manuais nos informam sobre as diversas vertentes constitutivas desse projeto.

ASPECTOS FUNCIONAIS da ORDEM DE CONSTITUINTES

O objetivo deste trabalho é fornecer uma interpretação funcional para a ordem de constituintes da sentença do português falado no Brasil (PB). Segundo a metodologia aqui adotada, as generalizações de natureza sintática decorrem necessariamente de generalizações de natureza semântica e pragmática. Os dados constituem uma amostragem representativa de sentenças do português falado, extraída de inquéritos do Projeto NURC. Como enfoque funcional prevê a coexistência de diferentes padrões de ordenação de constituintes, usados em diferentes condições e para diferentes propósitos, postula-se que o PB dispõe de dois padrões igualmente relevantes: a ordem SVO e a ordem VSO, ambos pragmaticamente motivados. Argumenta-se ainda que tais motivações pragmáticas relaciona, diacronicamente, os padrões funcionais em uso a uma mudança em curso na classificação tipológica do PB de um tipo primitivo VSO para o tipo SVO atualmente predominante.

Parceria intergeracional e formação docente

O artigo focaliza o potencial formativo da parceria intergeracional na formação docente -inicial e continuada -, tendo por pressuposto a existência de uma cultura profissional específica do magistério (JULIA, 2001), o papel dos professores como produtores de saberes sobre o ensino (SHULMAN, 1986; TARDIF; LESSARD; LAHAYE, 1991), bem como a importância da escola como eixo para a formação docente (NÓVOA, 1999; AZANHA, 2000). São apresentados dados sobre um trabalho formativo que, desde 2006, vem sendo desenvolvido na cidade de Rio Claro, reunindo estudantes do curso de Pedagogia da UNESP e professores dos anos iniciais do ensino fundamental. de acordo com a proposta, futuros professores e professores em exercício atuam como parceiros, em uma relação de colaboração nas atividades docentes. Além da formação profissional dos sujeitos envolvidos, o investimento nessas parcerias tem em vista o desenvolvimento de uma dimensão mais colaborativa no seio da cultura do magistério.

Filmes na formação de futuros professores: educar o olhar

Neste artigo, trago parte de minha experiência como professora de futuros professores de Matemática quando ministrei a disciplina Didática, no ano de 2010. Socializo aqui algumas das práticas instituídas nesse contexto e que resgatam a potencialidade dos filmes e da escrita no processo formativo dos alunos. Problematizo a importância de assistir juntos a um filme, já que essa experiência estética possibilita promover o conhecimento, o sentimento e a ação. Trago a voz dos meus alunos, documentada nos registros semanais elaborados por eles, para dizer das marcas que os filmes deixaram no percurso formativo de cada um como futuros professores de Matemática. Ao resgatar essa prática, enfatizo a importância de educar o olhar na busca pela constituição de um professor comprometido com uma educação e uma sociedade mais justa e democrática.

Purification, partial characterization and preliminary X-ray diffraction analysis of a mannose-specific lectin from Cymbosema roseum seeds

A lectin from Cymbosema roseum seeds (CRL) was purified, characterized and crystallized. The best crystals grew in a month and were obtained by the vapour-diffusion method using a precipitant solution consisting of 0.1 M Tris-HCl pH 7.8, 8% (w/v) PEG 3350 and 0.2 M proline at a constant temperature of 293 K. A data set was collected to 1.77 angstrom resolution at a synchrotron-radiation source. CRL crystals are orthorhombic, belonging to space group P2(1)2(1)2(1). Crystallographic refinement and full amino-acid sequence determination are in progress.

A PC compatible Brazilian software for obtaining thermal histories using apatite fission track analysis

In this work a software developed in the Instituto de Fisica Gleb Wataghin, IFGW, UNICAMP, Campinas, SP, Brazil for obtaining thermal histories using apatite fission track analysis is presented. This software works in Microsoft-Windows environment. It will be freely disposable in the web site of the Departamento de Raios Cosmicos, IFGW, UNICAMP. Thermal histories obtained through this software are compared with those deduced using Monte Trax the software compatible with Apple Macintosh developed by Gallagher. (C) 2001 Elsevier B.V. Ltd. All rights reserved.

Crystallization and preliminary X-ray diffraction analysis of XAC1151, a small heat-shock protein from Xanthomonas axonopodis pv. citri belonging to the alpha-crystallin family

The hspA gene (XAC1151) from Xanthomonas axonopodis pv. citri encodes a protein of 158 amino acids that belongs to the small heat-shock protein ( sHSP) family of proteins. These proteins function as molecular chaperones by preventing protein aggregation. The protein was crystallized using the sitting-drop vapour-diffusion method in the presence of ammonium phosphate. X-ray diffraction data were collected to 1.65 angstrom resolution using a synchrotron-radiation source. The crystal belongs to the rhombohedral space group R3, with unit-cell parameters a = b = 128.7, c = 55.3 angstrom. The crystal structure was solved by molecular-replacement methods. Structure refinement is in progress.

Deposition of controlled thickness ultrathin SnO2 : Sb films by spin-coating

The technological interest in transparent conductive oxide films (TCOs) has motivated several works in processing techniques, in order to obtain adequate routes to application. In this way, this work describes a new route to obtain antimony-doped tin oxide (ATO) films, based in colloidal dispersions of oxide nanocrystals. The nanoparticles were obtained by a hydrolisis method, using SnCl2 and SbCl3 in ethanolic solutions. The residual halides were removed by dyalisis, obtaining a limpid and transparent colloidal suspension. By this, the method offers the advantage of producing ultrathin films without organic contaminants. This route was employed to produce films with 5, 10, 14, and 18 mol% Sb doping, with thickness ranging from 40 to 70 nm. The physical characterization of the samples showed a uniform layer deposition, resulting in good packing density and high transmittance. A preliminar electrical study confirmed the low electrical resistivity even in the ultrathin films, in such level similar of reported data. The method described is similar in some aspects to layer-by-layer (LbL) techniques, allowing fine control of thickness and interesting properties for ultrathin films, however, with low cost when compared to similar routes.

What is Consciousness? Towards a Preliminary Definition

There is little or no general agreement about what researchers should focus on when studying consciousness. The most active scientific studies often use the methods of Cognitive Neuroscience and focus mainly on vision. Other aspects and contents of consciousness, namely thoughts and emotions, are much less studied, possibly leading to a biased view of what consciousness is and how it works. In this essay we describe what we call a referential nucleus, implicit in much of consciousness research. In this context, 'consciousness' refers to (partially) reportable content experienced by living individuals. We then discuss the philosophical concept of a phenomenal world and another contemporary view that conscious experience involves, besides integration of information in the brain, participation in action-perception cycles in a natural, social and cultural environment. These views imply a need to reconceptualize 'qualia' as the conscious aspect of subjective experiences, thus stating properties of consciousness that pose serious challenges to an exclusive approach via Cognitive Neuroscience, because experimental settings oversimplify conscious experiences, narrowing them to fragments correlated with measured brain activity and behaviour In conclusion we argue that a science of consciousness requires a broad interdisciplinary range of research, including qualitative methods from the Human Sciences.

Estimativas de parâmetros genéticos e fenotípicos para características de crescimento até a desmama em bovinos da raça Canchim

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Anatomical investigation of the slender catshark Schroederichthys tenuis Springer, 1966, with notes on intrageneric relationships (Chondrichthyes: Carcharhiniformes: Scyliorhinidae)

The slender catshark Schroedericthys tenuis Springer, 1966, originally described from two immature males, is redescribed on the basis of 12 specimens of both sexes, juveniles and adults (as well as the holotype and paratype). The supplementary specimens were collected off the northern coast of Brazil between Amapá and Pará states. Aspects of its external morphology, color pattern, dermal denticles, dentition, vertebral counts, and the cephalic, clasper and pectoral fin skeleton are described in detail and fully illustrated. These features are compared with those of congeneric species. Our observations support preliminary results of work in progress that S. maculatus Springer, 1966, S. tenuis and S. saurisqualus Soto, 2003 form a monophyletic group, mostly on the basis of neurocranial morphology, and that S. bivius (Smith, 1838) and S. chilensis (Guichenot, 1848) should be removed from Schroederichthys. Copyright © 2006 Magnolia Press.

O silêncio das musas: Épico, ciência e poesia em Haroldo de Campos

The epic and science seem to have been the most important concerns of the Brazilian author Haroldo de Campos (1929-2003) in his last twenty years of life. The books Finismundo: a última viagem and A máquina do mundo repensada are two significant works in his aesthetical journey. This paper presents some strategies for reading both books, in which the relationship between those themes is emphasized. As a starting point, it is believed that the analogy between science and the epic does not represent a paradigm of reading on which the poetry of Harold de Campos intends to base itself, but a way of thinking about the political and literary concerns that constitute its own situation. The creation of a poetics of adventure as an alternative to the end of utopia and the affirmation of a principle of indeterminacy as a way to oppose the interpretations immediately available in the present constitute two of the main interests found in this mode of reading.

Recent applications of analytical techniques for quantitative pharmaceutical analysis: A review

The intension of this paper was to review and discuss some of the current quantitative analytical procedures which are used for quality control of pharmaceutical products. The selected papers were organized according to the analytical technique employed. Several techniques like ultraviolet/visible spectrophotometry, fluorimetry, titrimetry, electroanalytical techniques, chromatographic methods (thin-layer chromatography, gas chromatography and high-performance liquid chromatography), capillary electrophoresis and vibrational spectroscopies are the main techniques that have been used for the quantitative analysis of pharmaceutical compounds. In conclusion, although simple techniques such as UV/VIS spectrophotometry and TLC are still extensively employed, HPLC is the most popular instrumental technique used for the analysis of pharmaceuticals. Besides, a review of recent works in the area of pharmaceutical analysis showed a trend in the application of techniques increasingly rapid such as ultra performance liquid chromatography and the use of sensitive and specific detectors as mass spectrometers.

Proposal of an On-demand Software Deployment System Based on Application Streaming, Virtualization Techniques and P2P Transport

This paper presents the work in progress of an on-demand software deployment system based on application virtualization concepts which eliminates the need of software installation and configuration on each computer. Some mechanisms were created, such as mapping of utilization of resources by the application to improve the software distribution and startup; a virtualization middleware which give all resources needed for the software execution; an asynchronous P2P transport used to optimizing distribution on the network; and off-line support where the user can execute the application even when the server is not available or when is out of the network. © Springer-Verlag Berlin Heidelberg 2010.