Instituições universitárias e produção do conhecimento

A produção do conhecimento em universidades é analisada como resultante da experiência individual em contexto histórico e sociocultural. Há fatores determinantes, de base epistemológica, e outros, condicionantes, na produção do conhecimento. Esta passa a adquirir significado estratégico para o país, inserido em uma economia globalizada. A aquisição de competitividade pelas nossas universidades dependerá de formas inovadoras de gestão de talentos.

Modelos explicativos em saúde coletiva: abordagem biopsicossocial e auto-organização

A complexidade do processo saúde-doença tem ensejado a proposição de uma diversidade de modelos explicativos. Fazemos uma breve revisão dessas propostas, confrontando três perspectivas: o modelo oriundo da Medicina do século XIX, a lógica da História Natural da Doença e o debate epidemiológico no contexto da Medicina Social latino-americana. Tomando-se como referência teórica a ideia de causalidade circular presente na teoria da auto-organização, propomos que os fatores causais privilegiados em cada um dos modelos explicativos acima não seriam conflitantes. Uma noção-chave para se pensar o processo de autoorganização biopsicossocial é o efeito baldwiniano, que descreve uma relação dialética ou coevolutiva entre processos naturais e socioculturais.

Coexisting spatio-temporal scales in neuroscience

In this study I propose an epistemological discussion of multiple spatio-temporal scales in neuroscience. Are such scales merely convenient levels of description of structure and function, or do they correspond to irreducible levels of brain organization? What criteria should we employ in order to reduce one level to another, or to identify levels that are not reducible to others? Should we think of these criteria as based on empirical and/or theoretical reasons? Beginning with an empirical criterion - the necessity of different experimental methodologies for the measurement of different phenomena in the same system - I summarize spatial and temporal scales currently used in neuroscience and discuss the possibility of a more general theoretical criterion. I conclude that multiscaling should be recognized as a central concept in the epistemology of neuroscience.

A Comparative Cytogenetic Analysis of 2 Bothriuridae Species and Overview of the Chromosome Data of Scorpiones

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Chloroquine inhibits Paracoccidioides brasiliensis survival within human monocytes by limiting the availability of intracellular iron

The mechanisms used by Paracoccidioides brasiliensis (Pb 18) to survive into monocytes are not clear. Cellular iron metabolism is of critical importance to the growth of several intracellular pathogens, including P. brasiliensis, whose capacity to multiply in mononuclear phagocytes is dependent on the availability of intracellular iron. Chloroquine, by virtue of its basic properties, has been shown to prevent release of iron from holotransferrin by raising endocytic and lysosomal pH, and thereby interfering with normal iron metabolism. Then, in view of this, we have studied the effects of CHLOR on P. brasiliensis multiplication in human monocytes and its effect on the murine paracoccidioidomycosis. CHLOR induced human monocytes to kill P. brasiliensis. The effect of CHLOR was reversed by FeNTA, an iron compound that is soluble at neutral to alkaline pH, but not by holotransferrin, which releases iron only in an acidic environment. CHLOR treatment of Pb 18-infected BALB/c mice significantly reduced the viable fungi recovery from lungs, during three different periods of evaluation, in a dose-dependent manner. This study demonstrates that iron is of critical importance to the survival of P. brasiliensis yeasts within human monocytes and the CHLOR treatment in vitro induces Pb 18 yeast-killing by monocytes by restricting the availability of intracellular iron. Besides, the CHLOR treatment in vivo significantly reduces the number of organisms in the lungs of Pb-infected mice protecting them from several infections. Thus, CHLOR was effective in the treatment of murine paracoccidioidomycosis, suggesting the potential use of this drug in patients' treatment.

O Agronegócio e o problema do trabalho infantil

This article attempts to identify and analyze the motives that led several sectors of agro-business to engage in the struggle for the eradication of child labor in Brazil, as launched by international organizations for the defense of children's and adolescents' rights. It is our hypothesis that economic globalization and the internationalization of children's rights have given visibility to the problem of child labor, thus demanding the mobilization of entrepreneurial sectors linked to agro-business productive chains in Brazil. The article is divided into four inter-related sections. In the first one, we attempt to provide evidence for the interference of social and labor problems within the ambit of the economic activities of the agro-business sector, within the current context of globalization. This is followed by a study of major UN, UNICEF and ILO investments to internalize children's rights and policies to combat child labor, giving salience to their repercussions in Brazil. In the third section, we analyze strategies adopted by firms linked to agro-business with the purpose of avoiding the use of child labor within their productive chains. Finally, we seek to understand the motivations that have led agro-businessmen to take part in the struggle against child labor. We conclude that firms linked to agro-business took up the project of combating child labor in virtue of the internationalization of children and adolescents' rights, the inclusion of social issues in international markets, the intensification of the fiscalization of public power, the growth of action around entrepreneurial social responsibility and increased consumer consciousness.

A contribuição da história dos conceitos à ciência da informação: Dimensões categórico-abstratas e analítico-causais

The history of concepts, albeit still little explored by information science, can provide important contributions for the study of key concepts that constitute the theoretical-conceptual framework in a scientifi c context. Thus, the history of concepts is presented as a tool for the study of diachronic and synchronic features of the scientific concept in Information Science. For such, it was imperative to understand the intersection of the categorical-abstract and analytical-causal dimensions, both relevant for constituting the very proposition of the history of concepts elaborated by Reinhart Koselleck.

Indicators for monitoring the implementation of the Convention on the Elimination of all Forms of Discrimination against Woman

Includes bibliography

Integration and trade diversion

Includes bibliography

Produção do arroz em função da adubação com silício e nitrogênio no sistema de sequeiro e irrigado por aspersão

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Obtenção de micro/nanopartículas poliméricas para o encapsulamento do fármaco bromidrato de galantamina

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Ensaios comparativos de mistura asfáltica pré-misturado a frio com adição de borracha de pneu

Pós-graduação em Ciência e Tecnologia de Materiais - FC

Os descaminhos da bem-aventurança: um estudo sobre a origem e os desdobramentos da concepção de crise paradigmática de Boaventura de Sousa Santos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Obstáculos epistemológicos à integralização das problemáticas sócio-ambientais em Sociologia

Pós-graduação em Ciências Sociais - FFC

Direito previdenciário e tutela urgente: concessão e revogação da tutela antecipada e a irrepetibilidade dos valores recebidos pelos segurados

Pós-graduação em Direito - FCHS