Duration of anticoagulation after venous thromboembolism in real world clinical practice.

INTRODUCTION: Venous thromboembolism (VTE) carries a considerable risk of recurrence and anticoagulants should be administered for a minimum of three months. Since little is known about real life management of VTE, we aimed to describe current practice in the secondary prevention of VTE. MATERIALS AND METHODS: Using the database of an international, prospective registry on patients treated for VTE, RIETE, information was collected on risk factors for VTE and bleeding, anticoagulant treatment, and clinical outcomes during follow up. Multivariate analysis using logistic regression was performed to identify predictors of treatment duration. RESULTS: Of 6944 patients with a first episode of VTE 41.1% had unprovoked VTE, 31.8% had transient risk factors, 27.1% had cancer. After the exclusion of patients who died during the first year of observation, the rate of patients treated for >12 months was 55.1%, 41.9%, and 43.2%, respectively (p<0.001). Pulmonary embolism at presentation, recurrence while on treatment, chronic heart failure and age >65 years were independently associated with treatment for >12 months. Body weight <75 kg, anemia, cancer, and the presence of transient risk factors were associated with treatment for 12 months or less. Major bleeding occurred more frequently than recurrent VTE in patients with VTE secondary to transient risk factors and cancer; fatal bleeding was more frequent than fatal recurrent PE in all subgroups. CONCLUSIONS: We observed heterogeneous duration of anticoagulant treatment for the secondary prevention of VTE. A substantial proportion of patients, in particular those with VTE secondary to transient risk factors, may be exposed to a possibly unnecessary risk of bleeding.

Arxiu de Relacions Laborals Teresa Claramunt

The "Teresa Claramunt Industrial Relations Registry" started as an initiative of the Grup d'Estudis Sociològics sobre la Vida Quotidiana i el Treball (Everyday Life and Work Sociological Research Group), with the aim of starting a compilation where could be centralized the main working papers and publication from enterprise and labour organizations, and to achieve a compilation of the edited production done by the labour ambit.

Diffantom: Whole-Brain Diffusion MRI Phantoms Derived from Real Datasets of the Human Connectome Project.

Food allergies are believed to be on the rise and currently management relies on the avoidance of the food. Hen's egg allergy is after cow's milk allergy the most common food allergy; eggs are used in many food products and thus difficult to avoid. A technological process using a combination of enzymatic hydrolysis and heat treatment was designed to produce modified hen's egg with reduced allergenic potential. Biochemical (SDS-PAGE, Size exclusion chromatography and LC-MS/MS) and immunological (ELISA, immunoblot, RBL-assays, animal model) analysis showed a clear decrease in intact proteins as well as a strong decrease of allergenicity. In a clinical study, 22 of the 24 patients with a confirmed egg allergy who underwent a double blind food challenge with the hydrolysed egg remained completely free of symptoms. Hydrolysed egg products may be beneficial as low allergenic foods for egg allergic patients to extent their diet. This article is protected by copyright. All rights reserved.

Criterios de Selección de Proveedores de Tecnologías de la Información y Comunicaciones en el Sector Financiero consecuencias de su Aplicación y Estudio de un Caso Real

Peer-reviewed

Hacia una teoría general de la Seguridad Marítima (Recensión Discurso ingreso Real Academia de Doctores)

Resumen discurso de ingreso

Capillary thermal desorption unit for near real-time analysis of VOCs at sub-trace levels. Application to the analysis of environmental air contamination and breath samples

A capillary microtrap thermal desorption module is developed for near real-time analysis of volatile organic compounds (VOCs) at sub-ppbv levels in air samples. The device allows the direct injection of the thermally desorbed VOCs into a chromatographic column. It does not use a second cryotrap to focalize the adsorbed compounds before entering the separation column so reducing the formation of artifacts. The connection of the microtrap to a GC–MS allows the quantitative determination of VOCs in less than 40 min with detection limits of between 5 and 10 pptv (25 °C and 760 mmHg), which correspond to 19–43 ng m−3, using sampling volumes of 775 cm3. The microtrap is applied to the analysis of environmental air contamination in different laboratories of our faculty. The results obtained indicate that most volatile compounds are easily diffused through the air and that they also may contaminate the surrounding areas when the habitual safety precautions (e.g., working under fume hoods) are used during the manipulation of solvents. The application of the microtrap to the analysis of VOCs in breath samples suggest that 2,5-dimethylfuran may be a strong indicator of a person's smoking status

Python y OpenCV aplicados a un caso de estudio real

Este trabajo se centra en el uso del lenguaje Python y la librería OpenCV de visión por computador para el seguimiento de crustáceos marinos en condiciones experimentales y determinar su comportamiento en un entorno social.

El Texto literario en el aula de español como lengua extranjera: Propuesta de programación didáctica: Últimas tardes con Teresa, de Juan Marsé

El treball aprofundeix en la importància dels textos literaris originals en les classes d’ELE (Espanyol com a Llengua Estrangera). S’estudien les principals línies de pensament sobre l’ensenyament de la literatura a l’aula d’ELE, i l’evolució de l’ensenyament. Es defensa que mitjançant l’ús de textos literaris originals els estudiants poden percebre una mostra de la diversitat expressiva de la llengua

Acción interpretativa para la finca pública de son real Mallorca

Cualquier acción dinamizadora que tenga como objetivo la desestacionalización turística basada en la explotación del patrimonio de la finca pública de Son Real, debe sustentarse necesariamente en una política gestora explícita, dotada de contenidos e integral.Pero ante todo debe tener una base de conocimiento, de contextualización del territorio y debe recoger todas las incidencias que afectan al bien para desarrollar estrategias consecuentes destinadas al conocimiento, conservación y difusión de este patrimonio, ligándolo a las demandas y necesidades de la sociedad actual y futura.

Comparação de metodologias para a determinação de umidade em geléia real

The aim of this paper was to compare methods of moisture determination to choose the best one for the determination of this parameter in royal jelly samples. Royal jelly is sensitive to high temperatures becoming dark and loosing volatiles in high temperatures. The methods were: vacuum oven at 60 ºC, 70 ºC, conventional oven at 105 ºC, Karl Fisher, dissecator with sulfuric acid and dryness with infrared light at 105 ºC. Based on the results, the best method was the dissecator with sulfuric acid for moisture determination in royal jelly.

Aplicação da CLAE para determinação do ácido 10-Hidróxi-2-decenóico (10-HDA) em geléia real pura e adicionada a mel brasileiro

The aim of this paper was to determine the 10-HDA in pure royal jelly and products containing royal jelly, using HPLC methodology. 10-HDA is the natural indicator of the presence of royal jelly in products and also gives the authenticity of pure royal jelly. The chromatographic conditions used were: isocratic system, C18-H column, auto sampler, diode array UV-VIS detector (225 nm), mobile phase with methanol/water (45:55), pH= 2.5 and a-naphtol as internal standard. The results obtained using laboratory samples for pure royal jelly were 2.37%, varying from 0.15% for honey with 10% of royal jelly to 2.10% for honey with 90% of royal jelly respectivelly. For commercial products, the 10-HDA content varied from no detectable to 0.026%. The recovery test presented a minumum of 100.44% The detection limit was 45.92 ng/mL and the quantification limit was 76.53 ng/mL.

Another Look at the Null of Stationary Real Exchange Rates: Panel Data with Structural Breaks and Cross-section Dependence

This paper re-examines the null of stationary of real exchange rate for a panel of seventeen OECD developed countries during the post-Bretton Woods era. Our analysis simultaneously considers both the presence of cross-section dependence and multiple structural breaks that have not received much attention in previous panel methods of long-run PPP. Empirical results indicate that there is little evidence in favor of PPP hypothesis when the analysis does not account for structural breaks. This conclusion is reversed when structural breaks are considered in computation of the panel statistics. We also compute point estimates of half-life separately for idiosyncratic and common factor components and find that it is always below one year.

El software libre al servicio de la economía productiva : Caso real de implantación de un ERP en una micro PYME

Este trabajo de fin de grado intenta, mediante el caso real de la implantación de un ERP en una micro PYME, ajustar a la realidad socioeconómica de la gran mayoría de empresas españolas las técnicas de implantación de software y de gestión de proyectos, usando como elemento conductor un ERP de software libre, para conseguir el triple objetivo de mantener los ratios de calidad deseados en cualquier proyecto de ingeniería de software, con unos costes asumibles por una micro PYME y satisfaciendo las necesidades de negocio.

Criterios de selección de proveedores de tecnologías de la información y comunicaciones en el sector financiero : Consecuencias de su aplicación y estudio de un caso real

Peer-reviewed

The effects of real time control of welding parameters on weld quality in plasma arc keyhole welding

Joints intended for welding frequently show variations in geometry and position, for which it is unfortunately not possible to apply a single set of operating parameters to ensure constant quality. The cause of this difficulty lies in a number of factors, including inaccurate joint preparation and joint fit up, tack welds, as well as thermal distortion of the workpiece. In plasma arc keyhole welding of butt joints, deviations in the gap width may cause weld defects such as an incomplete weld bead, excessive penetration and burn through. Manual adjustment of welding parameters to compensate for variations in the gap width is very difficult, and unsatisfactory weld quality is often obtained. In this study a control system for plasma arc keyhole welding has been developed and used to study the effects of the real time control of welding parameters on gap tolerance during welding of austenitic stainless steel AISI 304L. The welding tests demonstrated the beneficial effect of real time control on weld quality. Compared with welding using constant parameters, the maximum tolerable gap width with an acceptable weld quality was 47% higher when using the real time controlled parameters for a plate thickness of 5 mm. In addition, burn through occurred with significantly larger gap widths when parameters were controlled in real time. Increased gap tolerance enables joints to be prepared and fit up less accurately, saving time and preparation costs for welding. In addition to the control system, a novel technique for back face monitoring is described in this study. The test results showed that the technique could be successfully applied for penetration monitoring when welding non magnetic materials. The results also imply that it is possible to measure the dimensions of the plasma efflux or weld root, and use this information in a feedback control system and, thus, maintain the required weld quality.