Impaired muscle Ca2+ and K+ regulation contribute to poor exercise performance post-lung transplantation

Lung transplant recipients (LTx) exhibit marked peripheral limitations to exercise. We investigated whether skeletal muscle Ca2+ and K+ regulation might be abnormal in eight LTx and eight healthy controls. Peak oxygen consumption and arterialized venous plasma [K+] (where brackets denote concentration) were measured during incremental exercise. Vastus lateralis muscle was biopsied at rest and analyzed for sarcoplasmic reticulum Ca2+ release, Ca2+ uptake, and Ca2+-ATPase activity rates; fiber composition; Na+-K+-ATPase (K+-stimulated 3-O-methylfluorescein phosphatase) activity and content ([3H]ouabain binding sites); as well as for [H+] and H+-buffering capacity. Peak oxygen consumption was 47% less in LTx (P < 0.05). LTx had lower Ca2+ release (34%), Ca2+ uptake (31%), and Ca2+-ATPase activity (25%) than controls (P < 0.05), despite their higher type II fiber proportion (LTx, 75.0 ± 5.8%; controls, 43.5 ± 2.1%). Muscle [H+] was elevated in LTx (P < 0.01), but buffering capacity was similar to controls. Muscle 3-O-methylfluorescein phosphatase activity was 31% higher in LTx (P < 0.05), but [3H]ouabain binding content did not differ significantly. However, during exercise, the rise in plasma [K+]-to-work ratio was 2.6-fold greater in LTx (P < 0.05), indicating impaired K+ regulation. Thus grossly subnormal muscle calcium regulation, with impaired potassium regulation, may contribute to poor muscular performance in LTx.

Factors influencing skin colour in cultured Australian snapper Pagrus auratus

Sea cage production of Australian snapper has been largely constrained during the past decade by abnormal skin pigmentation which has negatively impacted marketability. The research described in this study identified dietary, environmental and harvesting techniques to successfully alter skin colour to potentially improve the viability of snapper aquaculture in Australia.

Comparing experiments of the stressed skin diaphragm spanning several and few purlins

Concerning the specialty of the testing of stressed skin diaphragm assembly, the current loading method of cantilever beam test is improved by the diagonally loading method. In order to investigate the differences of the shear behavior between the stressed skins spanning several purlins and few purlins , which have the same forms and spaces of the connections and purlins, comparing experiments are carried out. Using the curve fitting method, the test results are quantified. The shear rigidity of two specimens is gained. It shows that the shear rigidity of the diaphragm spanning several purlins is quite higher than that spanning few purlins, but the carrying capacity of the former is a little lower than that of the latter.

Field test study on the shear behaviour of stressed skin diaphragm spanning several purlins

Although profiled steel sheets have the diaphragm effect in steel structure, since there is no specific code to follow in China, it is only used as the reservation of the structural stiffness.So it results in economic wastes.In order to investigate the contribution of stressed skin to the overall stiffness, field tests are carried out to measure the lateral stiffness of the frames with and without stressed skin diaphgram.Based on the superposition principle and using the curve fitting method, the test results are quantified.The shear rigidity of stressed skin diaphgram spanning several purlins is gained indirectly.It shows that the shear rigidity of the diaphragm between two frames is even close to the lateral stiffness of one frame.

The effect of skin passing on the material behavior of metal strip in pure bending and tension

The metal strip used in roll forming has often been preprocessed by (tension or roller) leveling or by skin-pass rolling, and as a consequence, may contain residual stresses. These stresses are not well observed by the tensile test, but could have a significant effect on the bending and springback behavior. With the advent of improved process design techniques for roll forming, including advanced finite element techniques, the need for precise material property data has become important. The major deformation mode of roll forming is that of bending combined with unloading and reverse bending, and hence property data derived from bend tests could be more relevant than that from tensile testing.

This work presents a numerical study on the effect of skin passing on the material behavior of stainless steel strip in pure bending and tension. A two dimensional (2-D) numerical model was developed using Abaqus Explicit to analyze the affect of skin passing on the residual stress profile across a section for various working conditions. The deformed meshes and their final stress fields were then imported as pre-defined fields into Abaqus Standard, and the post-skin passing material behavior in pure bending was determined. The results show that a residual stress profile is introduced into the steel strip during skin passing, and that its shape and stress level depend on the overall thickness reduction as well as the number of rolling passes used in the skin passing process. The material behavior in bending and the amount of springback changed significantly depending on the skin pass condition.

Skin pedagogies and abject bodies

How does the beauty industry ‘narrate the skin’? What does it teach women from different cultural groups about the female body? How does skin function as a site where female subjection and abjection are produced and reproduced? In this paper we examine the skin industry pointing to its extreme commodification of the female body and to the inexcusable pressure this places on females of most age and cultural groups.We focus on two examples. Firstly, we show what the skin industry teaches girls and women about both their skin colour ‘problems’ and desirable practices of whitening and, secondarily, tanning. Secondly, we consider what the cosmetic surgery industry teaches us about female bodily ‘imperfections’ linked to certain ethnic and racial groups and the necessary ‘remedies’. Overall we show how the socio-cultural normalization of perfect skin is a product of a range of contemporary and enduring social and cultural forces overlain by complex pedagogies of power, expertise and affect.

Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in type 1 diabetes: a systematic review

Aims For selected individuals with complex Type 1 diabetes, pancreatic islet transplantation (IT) offers the potential of excellent glycaemic controlwithout significant hypoglycaemia, balanced by the need for ongoing systemic immunosuppression. Increasingly, patient-reported outcomes (PROs) are considered alongside biomedical outcomes as a measure of transplant success. PROs in IT have not previously been compared directlywith the closest alternate treatment option, pancreas transplant alone (PTA) or pancreas after kidney (PAK).

Methods We used a Population, Intervention, Comparisons, Outcomes (PICO) strategy to search Scopus and screened 314 references for inclusion.

Results Twelve studies [including PRO assessment of PAK, PTA, islet-after kidney (IAK) and islet transplant alone (ITA); n = 7–205] used a total of nine specified and two unspecified PRO measures. Results were mixed but identified some benefits which remained apparent up to 36 months post-transplant, including improvements in fear of hypoglycaemia, as well as some aspects of diabetes-specific quality of life (QoL) and general health status. Negative outcomes included short-term pain associated with the procedure, immunosuppressant side effects and depressed mood associated with loss of graft function.

Conclusions The mixed resultsmay be attributable to limited sample sizes. Also, some PROmeasures may lack sensitivity to detect actual changes, as they exclude issues and domains of life likely to be important forQoL post-transplantation and when patients may no longer perceive themselves to have diabetes. Thus, the full impact of islet ⁄ pancreas transplantation (alone or after kidney) on QoL is unknown. Furthermore, no studies have assessed patient satisfaction, which may highlight further advantages and disadvantages of transplantation.