Neogene diatoms of the Japan Sea

A series of excellent upper Miocene through Quaternary diatomaceous sequences recovered at four sites during Leg 127 was examined for diatoms. The diagenetic transition from opal-A to opal-CT is a diachronic horizon from the uppermost part of the Denticulopsis katayamae Zone (8.5 Ma) at Hole 797B to the uppermost part of the Neodenticula kamtschatica Zone (5.73 Ma) at Hole 795A. The diatom zonation of Koizumi (1985) best divides the upper Miocene to Quaternary sequences above the opal-A/opal-CT boundary and also is useful to date carbonate concretions including diatoms below the boundary. Forty diatom datum levels were evaluated biostratigraphically based on the sediment accumulation rate curve, and several isochronous datum levels are newly proposed for the Japan Sea area. A warm-water current did not penetrated into the Japan Sea through the Tsushima strait during the late Miocene and Pliocene time, because subtropical warm-water diatoms are essentially not present in such sediment samples. The occurrences of diatom are cyclic throughout the Quaternary sediments and are affected by eustatic sea level changes.

A deep-sea coral record of the North Atlantic

Our record of Younger Dryas intermediate-depth seawater D14C from North Atlantic deep-sea corals supports a link between abrupt climate change and intermediate ocean variability. Our data show that northern source intermediate water (~1700 m) was partially replaced by 14C-depleted southern source water at the onset of the event, consistent with a reduction in the rate of North Atlantic Deep Water formation. This transition requires the existence of large, mobile gradients of D14C in the ocean during the Younger Dryas. The D14C water column profile from Keigwin (2004) provides direct evidence for the presence of one such gradient at the beginning of the Younger Dryas (~12.9 ka), with a 100 per mil offset between shallow (<~2400 m) and deep water. Our early Younger Dryas data are consistent with this profile and also show a D14C inversion, with 35 per mil more enriched water at ~2400 m than at ~1700 m. This feature is probably the result of mixing between relatively well 14C ventilated northern source water and more poorly 14C ventilated southern source intermediate water, which is slightly shallower. Over the rest of the Younger Dryas our intermediate water/deepwater coral D14C data gradually increase, while the atmosphere D14C drops. For a very brief interval at ~12.0 ka and at the end of the Younger Dryas (11.5 ka), intermediate water D14C (~1200 m) approached atmospheric D14C. These enriched D14C results suggest an enhanced initial D14C content of the water and demonstrate the presence of large lateral D14C gradients in the intermediate/deep ocean in addition to the sharp vertical shift at ~2500 m. The transient D14C enrichment at ~12.0 ka occurred in the middle of the Younger Dryas and demonstrates that there is at least one time when the intermediate/deep ocean underwent dramatic change but with much smaller effects in other paleoclimatic records.

A sedimentological, faunal, and isotopic record of the middle-to-late Pliocene transition at DSDP Hole 80-548

Hydraulic piston coring at DSDP Site 548, on the upper continental slope southwest of Ireland, recovered a nearly complete Pliocene section spanning 103 m of sediment. The sediments are greenish gray carbonate-rich hemipelagites containing abundant nannofossils and foraminifers. Grain-size analysis demonstrates that the texture of the section is fairly constant, with most of the variation occurring in 63- to 32-µm and < 2-µm fractions. Previous research has shown that the middle-to-late Pliocene transition in the North Atlantic was marked by the appearance of the planktonic foraminiferal species Globorotalia inflata and by the first occurrence of significant quantities of ice-rafted sediment grains in deep-sea sediments. The latter is taken to represent the first important development of Northern Hemisphere glaciation. The first appearance of G. inflata is carefully documented for Site 548 and is demonstrated to be an evolutionary datum at this site, rather than an ecologically controlled first appearance. Surface ocean conditions represented in the sediment section spanning the appearance of G. inflata were strongly cyclic, resulting in large periodic changes in the abundances of Globorotalia puncticulata and N. acostaensis. The benthic foraminiferal population was studied in detail over the middle-to-upper Pliocene transition to establish the nature and behavior of the intermediate-depth water mass in the northeastern Atlantic at the time of ice-sheet growth in the Northern Hemisphere. This water mass is presently warm and saline, having its source in the Mediterranean Sea. The benthic data show that the intermediate-depth water mass was undergoing a series of progressive changes over the interval including the first appearance of G. inflata. These changes are particularly reflected in the relative abundances of Globocassidulina subglobosa (Brady), Uvigerina, and Ehrenbergina. Also, the mean size of individuals in the G. subglobosa populations shows systematic variation, indicating changing intermediate-depth water properties. Oxygen-isotope analyses show that the intermediate-depth water mass was cold during the middle-to-late Pliocene transition. This interpretation is supported by the relative abundances of benthic foraminiferal species. Hence, the intermediate-depth northeastern Atlantic water mass of the middle to late Pliocene was considerably different from the intermediate-depth water mass of the present.

Measurement of the electron neutrino charged-current interaction rate on water with the T2K ND280 π0 detector

This paper presents a measurement of the charged current interaction rate of the electron neutrino beam component of the beam above 1.5 GeV using the large fiducial mass of the T2K π0 detector. The predominant portion of the νe flux (∼85%) at these energies comes from kaon decays. The measured ratio of the observed beam interaction rate to the predicted rate in the detector with water targets filled is 0.89 ± 0.08 (stat.) ± 0.11 (sys.), and with the water targets emptied is 0.90 ± 0.09 (stat.) ± 0.13 (sys.). The ratio obtained for the interactions on water only from an event subtraction method is 0.87 ± 0.33 (stat.) ± 0.21 (sys.). This is the first measurement of the interaction rate of electron neutrinos on water, which is particularly of interest to experiments with water Cherenkov detectors.

Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs.

BACKGROUND Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving IgE antibodies directed towards environmental allergens. We previously identified a ~1.5 Mb locus on canine chromosome 27 associated with CAD in German shepherd dogs (GSDs). Fine-mapping indicated association closest to the PKP2 gene encoding plakophilin 2. RESULTS Additional genotyping and association analyses in GSDs combined with control dogs from five breeds with low-risk for CAD revealed the top SNP 27:19,086,778 (p = 1.4 × 10(-7)) and a rare ~48 kb risk haplotype overlapping the PKP2 gene and shared only with other high-risk CAD breeds. We selected altogether nine SNPs (four top-associated in GSDs and five within the ~48 kb risk haplotype) that spanned ~280 kb forming one risk haplotype carried by 35 % of the GSD cases and 10 % of the GSD controls (OR = 5.1, p = 5.9 × 10(-5)), and another haplotype present in 85 % of the GSD cases and 98 % of the GSD controls and conferring a protective effect against CAD in GSDs (OR = 0.14, p = 0.0032). Eight of these SNPs were analyzed for transcriptional regulation using reporter assays where all tested regions exerted regulatory effects on transcription in epithelial and/or immune cell lines, and seven SNPs showed allelic differences. The DNA fragment with the top-associated SNP 27:19,086,778 displayed the highest activity in keratinocytes with 11-fold induction of transcription by the risk allele versus 8-fold by the control allele (pdifference = 0.003), and also mapped close (~3 kb) to an ENCODE skin-specific enhancer region. CONCLUSIONS Our experiments indicate that multiple CAD-associated genetic variants located in cell type-specific enhancers are involved in gene regulation in different cells and tissues. No single causative variant alone, but rather multiple variants combined in a risk haplotype likely contribute to an altered expression of the PKP2 gene, and possibly nearby genes, in immune and epithelial cells, and predispose GSDs to CAD.

Composition of rocks and minerals from the Mid-Atlantic Ridge 5-7°N

The monograph summarizes geological and metallogenic data on the Mid-Atlantic Ridge obtained during research expeditions of the Geological Institute RAS in 2000-2003. Formation of the earth crust in the region, structure of the rift zone, structure of the newly discovered Bogdanov Fracture Zone, neotectonic deformations, metallogenic peculiarities, prospecting criteria of ocean ore mineralization are under consideration.

A history of the Office of Censorship [microform].

Accompanied by: A guide to History of the Office of Censorship / edited by Paul Kesaris (6 p. ; 22 cm.).

Treasury, Postal Service, and general government appropriations for fiscal year 1982 [microform] : hearings before a subcommittee of the Committee on Appropriations, House of Representatives, Ninety-seventh Congress, first session /

Includes index.

Ḥilyat al-ʻaṣr al-jadīd fī shamāʼil al-malik al-ḥamīd [microform] /

Microfilm.

The world's orators : comprising the great orations of the world's history with introductory essays, biographical sketches and critical notes /

v. 1. Orators of ancient Greece.--v. 2. Orators of ancient Rome.--v. 3. Orators of the early and mediaeval church.--v. 4. Orators of the reformation era.--v. 5. Orators of modern Europe.--v. 6-7. Orators of England.--v. 8-10. Orators of America.

Notice sur la cour du grand-seigneur, son sérail, son harem, la famille du sang impérial, sa maison militaire, etc. : suivie d'un essai historique sur la religion mahométane, son culte et ses ministres /

Mode of access: Internet.