989 resultados para Reduced Neutral Red


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En la era digital actual, Internet forma parte de nuestras vidas, y ha aportado cambios a lasociedad globalizada. Algunos de estos cambios nos permiten nuevas formas de relacionarnos y degestionar el conocimiento, dando sentido al término que hoy entendemos como sociedad-red.Por eso, en el entorno que nos envuelve existen continuamente acciones colaborativas globales quefomentan la comunicación y se comparte información de diversos tipos, con la finalidad deaprender y mantenerse constantemente informado. Específicamente, los centros educativos no sequedan al margen ya que requiere preparar estudiantes para esta sociedad.Estos cambios en la sociedad presentan grandes desafíos para el centro educativo, que nopermiten ser afrontados solamente desde el aula. Los centros requieren adaptarse a un modelocompatible con la sociedad-red, y por ello, se sugieren un modelo centro-red, que presente unaestructura de una organización compatible con la era en el que estamos inmersos.Las redes de colaboración en los centros permite intercambiar información y aportar valor a laeducación con el objetivo de la mejora educativa. En este sentido, los centros educativos debendisponer de características que permitan ser flexibles, adaptarse a los agentes y organizaciones quele envuelven. Pero la estructura actual de un centro educativo es rígida y por tanto esta evoluciónrepresenta uno de los mayores desafíos para el sistema educativo.En esta linea, en los centros de Formación Profesional existe una tendencia hacia modeloscolaborativos con el tejido empresarial, entre otros agentes, y es en este punto donde este proyectopretende centrar el foco de la investigación. Con más exactitud, en la creación de una red decolaboración con el agente que el centro educativo seleccione.Específicamente las TIC forman un papel esencial, y se deben poner al servicio del problemaque apuntábamos para ayudar a solventarlo. En este sentido, es adecuado un diseño del artefactocon Software Libre que tiene múltiples beneficios para este objetivo, pero que destacamos el que ami parecer es el más importante; la vinculación con la filosofía de compartir el conocimiento, quegarantiza la simbiosis con la red colaborativa y es por esta razón que el tema de la investigación esrelevante para el centro educativo.Tal y como se mencionaba previamente, las TIC pueden ayudar a fomentar la red colaborativa,pero no sólo el artefacto TIC generado en este proyecto debe cumplir características como laflexibilidad, también es crítico que el centro educativo y los agentes de la red interioricen la culturacolaborativa en sus acciones con la implicación y compromiso que se requiere. Pero como podemosPágina 6Universitat Oberta de Catalunya Trabajo Final de Máster - Software Libreimaginar, ese cambio de cultura, no es una tarea sencilla y presenta problemas. Para mitigarlos yfomentar la cultura en red, se requieren procesos específicos que permitan incorporarla en la medidade lo posible. Para ello, la combinación de la innovación sistémica y el diseño de la investigación eneducación resultan metodologías apropiadas.Por eso, investigaremos durante este proceso cómo las redes de colaboración y el SoftwareLibre permiten adaptar el centro al entorno, cómo pueden ayudar al centro a potenciar la FormaciónProfesional y garantizar la durabilidad de las acciones, con el objetivo que perdure el conocimientoy la propia red de colaboración para una mejora educativa.

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Parental effort is usually associated with high metabolism that could lead to an increase in the production of reactive oxidative species giving rise to oxidative stress. Since many antioxidants involved in the resistance to oxidative stress can also enhance immune function, an increase in parental effort may diminish the level of antioxidants otherwise involved in parasite resistance. In the present study, we performed brood size manipulation in a population of great tits (Parus major) to create different levels of parental effort. We measured resistance to oxidative stress and used a newly developed quantitative PCR assay to quantify malarial parasitaemia. We found that males with an enlarged brood had significantly higher level of malarial parasites and lower red blood cell resistance to free radicals than males rearing control and reduced broods. Brood size manipulation did not affect female parasitaemia, although females with an enlarged brood had lower red blood cell resistance than females with control and reduced broods. However, for both sexes, there was no relationship between the level of parasitaemia and resistance to oxidative stress, suggesting a twofold cost of reproduction. Our results thus suggest the presence of two proximate and independent mechanisms for the well-documented trade-off between current reproductive effort and parental survival.

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The first phase of the study of intersection lighting and accidents conducted using data from 1964 through 1971 yielded the conclusion that the installation of intersection lighting reduced the nighttime accident frequency by 52%. With this conclusion, this project (the second phase), was initiated to determine the relative benefit of a higher level of lighting as opposed to minimum lighting. Twenty pairs of intersections with similar geometrics were selected. Some lights were turned out at one intersection of each pair to produce a lighting level differential. Based on the results of this research, the lighting level of lighted rural at-grade intersections does not have a significant effect on the accident frequency. At the nineteen "reduced lighting" intersections, the number of lighted luminaires was reduced from 101 to 46 with a corresponding reduction in energy consumption of over 100,000 Kilowatt hours per year. This energy conservation measure could reduce consumption by an estimated 1,000,000 Kilowatt hours per year if initiated on more than 200 earlier primary, rural installations.

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Introduction: In children with cystic fibrosis (CF), low immunoglobulin (IgG) levels have been reported to be associated with significantly less severe lung disease. However, decreased IgG can be a sign for common variable immunodeficiency (CVID) and affect clinical outcome. The aim of this study was to analyze clinical and serological data of patients having low IgG levels in routine blood tests at annual assessment, particularly their antibody response to polysaccharide antigens. Method: Retrospective chart review of demographic data of CF patients followed at the pediatric CF clinic throughout 2009. Clinical parameters (genotype, pancreas sufficiency, FEV1), presence of Pseudomonas aeruginosa (PA) and number of exacerbations per year were correlated with immunoglobulin and vaccination antibodies levels (antibodies to pneumococcal serotypes 14, 19, 23, 1, 5 and 7F measured by enzyme-linked immune-sorbent assay). Results: 4 out of 60 patients (6.7%) had lower IgG-levels for age. Ages ranged from 1 year 8 months to 11 years, 2 boys, 2 girls. Three patients were delF508 homozygotes, one heterozygote composite delF508/G542X. All were pancreatic insufficient. FEV1 ranged from 74 to 108%. One patient never had colonization by PA, 2 had intermittent PA colonization and one was chronically infected. After conjugated vaccination all patients had protective antibodies against serotypes 14, 19, 23F. For serotypes not included in the vaccine, only one patient had protective titers for 1 out of 3 serotypes. None of the patients had received unconjugated pneumococcal vaccine. There was no significant clinical difference in FEV1, PA colonization or number of exacerbations according to IgG and vaccination antibody levels. Conclusion: Cystic Fibrosis patients with low immunoglobulin levels have normal antibody response to protein antigens. However, despite recurrent infections, there seems to be delayed or deficient antibody response to polysaccharide antigens. Prospective studies are needed to evaluate the development of polysaccharide antibody responses in CF-patients to monitor for CVID. With early detection of CF by newborn screening program, long term follow up could be started early in childhood.

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Problem solving (including insight, divergent thinking) seems to rely on the right hemisphere (RH). These functions are difficult to assess behaviorally. We propose anagram resolution as a suitable paradigm. University students (n=32) performed three tachistoscopic lateralized visual half-field experiments (stimulus presentation 150ms). In Experiment 1, participants recalled four-letter strings. Subsequently, participants provided solutions for four-letter anagrams (one solution in Experiment 2; two solutions in Experiment 3). Additionally, participants completed a schizotypy questionnaire (O-LIFE). Results showed a right visual field advantage in Experiment 1 and 2, but no visual field advantage in Experiment 3. In Experiment 1, increasing positive schizotypy associated with a RH performance shift. Problem solving seems to require increasingly the RH when facing several rather than one solution. This result supports previous studies on the RH's role in remote associative, metaphor and discourse processing. The more complex language requirements, the less personality traits seem to matter.

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Selostus: Puna-apilan pysyvyys apila-heinänurmessa sekä seosnurmen satoisuus ja laadun muutokset erilaisissa kasvuoloissa

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The objective of this study was to assess the development response of cultivated rice and red rice to different increases in minimum and maximum daily air temperatures, in Santa Maria, Rio Grande do Sul State, Brazil. One hundred years climate scenarios of temperatures 0, +1, +2, +3, +4, and +5ºC, with symmetric and asymmetric increases in minimum and maximum daily air temperatures were created, using the LARS-WG Weather Generator, and a 1969-2003 database. Nine cultivated rice genotypes (IRGA 421, IRGA 416, IRGA 417, IRGA 420, BRS 7 TAIM, BR-IRGA 409, EPAGRI 109, EEA 406 and a hybrid), and two red rice biotypes (awned black hull-ABHRR, and awned yellow hull-AYHRR) were used. The dates of panicle differentiation (R1), anthesis (R4), and all grains with brown hulls (R9) were estimated with a nonlinear simulation model. Overall, the duration of the emergence-R1 phase decreased, whereas the duration of the R1-R4 and R4-R9 phases most often increased, as temperature increased in the climate change scenarios. The simulated rice development response to elevated temperature was not the same, when the increase in minimum and maximum temperature was symmetric or asymmetric.

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Specialization is common in most lineages of insect herbivores, one of the most diverse groups of organisms on earth. To address how and why specialization is maintained over evolutionary time, we hypothesized that plant defense and other ecological attributes of potential host plants would predict the performance of a specialist root-feeding herbivore (the red milkweed beetle, Tetraopes tetraophthalmus). Using a comparative phylogenetic and functional trait approach, we assessed the determinants of insect host range across 18 species of Asclepias. Larval survivorship decreased with increasing phylogenetic distance from the true host, Asclepias syriaca, suggesting that adaptation to plant traits drives specialization. Among several root traits measured, only cardenolides (toxic defense chemicals) correlated with larval survival, and cardenolides also explained the phylogenetic distance effect in phylogenetically controlled multiple regression analyses. Additionally, milkweed species having a known association with other Tetraopes beetles were better hosts than species lacking Tetraopes herbivores, and milkweeds with specific leaf area values (a trait related to leaf function and habitat affiliation) similar to those of A. syriaca were better hosts than species having divergent values. We thus conclude that phylogenetic distance is an integrated measure of phenotypic and ecological attributes of Asclepias species, especially defensive cardenolides, which can be used to explain specialization and constraints on host shifts over evolutionary time.

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Investigaremos cómo las redes de colaboración y el softwarelibre permiten adaptar el centro educativo al entorno, cómo pueden ayudar al centro a potenciar la formación profesional y garantizar la durabilidad de las acciones, con el objetivo que perdure el conocimiento y la propia red de colaboración para una mejora educativa.

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Abstract The giant hogweed (Heracleum mantegazzianum) has successfully invaded 19 European countries as well as parts of North America. It has become a problematic species due to its ability to displace native flora and to cause public health hazards. Applying population genetics to species invasion can help reconstruct invasion history and may promote more efficient management practice. We thus analysed levels of genetic variation and population genetic structure of H. mantegazzianum in an invaded area of the western Swiss Alps as well as in its native range (the Caucasus), using eight nuclear microsatellite loci together with plastid DNA markers and sequences. On both nuclear and plastid genomes, native populations exhibited significantly higher levels of genetic diversity compared to invasive populations, confirming an important founder event during the invasion process. Invasive populations were also significantly more differentiated than native populations. Bayesian clustering analysis identified five clusters in the native range that corresponded to geographically and ecologically separated groups. In the invaded range, 10 clusters occurred. Unlike native populations, invasive clusters were characterized by a mosaic pattern in the landscape, possibly caused by anthropogenic dispersal of the species via roads and direct collection for ornamental purposes. Lastly, our analyses revealed four main divergent groups in the western Swiss Alps, likely as a consequence of multiple independent establishments of H. mantegazzianum.

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Aspergillus fumigatus grows well at neutral and acidic pH in a medium containing protein as the sole nitrogen source by secreting two different sets of proteases. Neutral pH favors the secretion of neutral and alkaline endoproteases, leucine aminopeptidases (Laps) which are nonspecific monoaminopeptidases, and an X-prolyl dipeptidase (DppIV). Acidic pH environment promotes the secretion of an aspartic endoprotease of pepsin family (Pep1) and tripeptidyl-peptidases of the sedolisin family (SedB and SedD). A novel prolyl peptidase, AfuS28, was found to be secreted in both alkaline and acidic conditions. In previous studies, Laps were shown to degrade peptides from their N-terminus until an X-Pro sequence acts as a stop signal. X-Pro sequences can be then removed by DppIV, which allows Laps access to the following residues. We have shown that at acidic pH Seds degrade large peptides from their N-terminus into tripeptides until Pro in P1 or P'1 position acts as a stop for these exopeptidases. However, X-X-Pro and X-X-X-Pro sequences can be removed by AfuS28 thus allowing Seds further sequential proteolysis. In conclusion, both alkaline and acidic sets of proteases contain exoprotease activity capable of cleaving after proline residues that cannot be removed during sequential digestion by nonspecific exopeptidases.