Rossignols amoureux : extrait d'"Hippolyte et Aricie" / Rameau, comp. ; Leïla Ben Sedira, S ; Quintette [i.e.] instrumental Pierre Jamet. Psyché / Manuel de Falla, comp. ; Leïla Ben Sedira, S ; G. Crunelle, fl. ; P. Jamet, hrp

Comprend : Rossignols amoureux / Rameau, comp. ; Leïla Ben Sedira, S ; G. Crunelle, fl. ; P. Jamet, hrp ; Psyché / Manuel de Falla, comp. ; Leïla Ben Sedira, S ; Quintette [i.e.] instrumental Pierre Jamet

G-1 Appeal Activity in the Public Assistance Programs, October 2005

G-1 Appeal Activity in the Public Assistance Programs - October 2005

G-1 Appeal Activity in the Public Assistance Programs, November 2005

G-1 - Appeal Activity in the Public Assistance - November, 2005

IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction.

Approximately 3% of the world population is chronically infected with the hepatitis C virus (HCV), with potential development of cirrhosis and hepatocellular carcinoma. Despite the availability of new antiviral agents, treatment remains suboptimal. Genome-wide association studies (GWAS) identified rs12979860, a polymorphism nearby IL28B, as an important predictor of HCV clearance. We report the identification of a novel TT/-G polymorphism in the CpG region upstream of IL28B, which is a better predictor of HCV clearance than rs12979860. By using peripheral blood mononuclear cells (PBMCs) from individuals carrying different allelic combinations of the TT/-G and rs12979860 polymorphisms, we show that induction of IL28B and IFN-γ-inducible protein 10 (IP-10) mRNA relies on TT/-G, but not rs12979860, making TT/-G the only functional variant identified so far. This novel step in understanding the genetic regulation of IL28B may have important implications for clinical practice, as the use of TT/G genotyping instead of rs12979860 would improve patient management.

Carte muette de France : autorisée par l'université / Lithographie de F.G. Levrault

Échelle(s) : [ca 1: 1 418 000], échelle de 20 myriamètres [= 14,1 cm]

G-1 Appeal Activity in the Public Assistance Programs, December 2005

Appeal Activity in the Public Assistance Programs - December 2005

G-1 Appeal Activity in the Public Assistance Programs, January 2006

Appeal Activity in the Public Assistance Programs, January 2006

G-1 Appeal Activity in the Public Assistance Programs, February 2006

Appeal Activity in the Public Assistance Programs, February 2006

G-1 Appeal Activity in the Public Assistance Programs, March 2006

G-1 - March 2006 - Appeal Activity in the Public Assistance Programs