The last thoughts of a naval officer, on the unlawfulness of war, &c., in a letter to his late Majesty, George the Fourth; and a series of letters to his Grace, the Archbishop of Canterbury ...

Mode of access: Internet.

The life of Saint Patrick, Apostle of Ireland, to which is added Saint Fiech's Irish Hymn; also a copious appendix of the various ecclesiastical institutions, &c. in Ireland,

Includes a hymn on the life, virtues and miracles of St. Patrick, composed by St. Fiech.

The history of the martyrs epitomised : A cloud of witnesses, or, The sufferers mirrour : made up of the swanlike songs, and other choice passages of a great number of martyrs and confessors, to the end of the sixteenth century, in their treatises, speeches, letters, prayers, &c. ... the whole alphabetically disposed /

LC copy bound in one volume.

Catalogue of a most interesting collection of manuscripts and books, of the poet Gray : the whole in beautiful condition : also of various editions of his works; a posthumous bust; a painting, "View of Gray's tomb and churchyard", by Baron; five original drawings by Westall, R. A.; &c. &c. which will be sold by auction, by Messrs. S. Leigh Sotheby & John Wilkinson ... at their house ... on Thursday, August 28th, 1851.

Library copy includes pen notations of prices realized.

The American gazetteer, exhibiting a full account of the civil divisions, rivers, harbors, Indian tribes, &c. of the American continent: also of the West-India, and other appendant islands: with a particular description of Louisiana.

Atlas issued separately. cf. Sabin, Bibl. Amer., 50939.

A rational account of the grounds of Protestant religion; being a vindication of the Lord Archbishop of Canterbury's Relation of a conference, &c. from the pretended answer by T. C. ...

An answer to Labyrinthus Cantuariensis by T. Carwell.

Theodore Thomas, a musical autobiography;

Mode of access: Internet.

A compendious system of anatomy : In six parts. Part I. Osteology. II. Of the muscles, &c. III. Of the abdomen. Part IV. Of the thorax. V. Of the brain and nerves. VI. Of the senses. From the Encyclopaedia. Illustrated with twelve large copperplates.

Austin

Beyond subsistence : labor standards and Third World development : report of the symposium co-convened by the Bureau of International Labor Affairs of the U.S. Department of Labor and by the Overseas Development Council, December 12-13, 1988, Washington, D.C.

Includes bibliographical references.

The life and letters of Lady Sarah Lennox, 1745-1826, daughter of Charles, 2nd Duke of Richmond, and successively the wife of Sir Thomas Charles Bunbury, Bart., and of the Hon. George Napier; also a short political sketch of the years 1760 to 1763,

Mode of access: Internet.

The life of Sir John Fowler, engineer, bart., K.C.M.G., etc.;

Mode of access: Internet.

Memoirs of the life and writings of Thomas Carlyle, with personal reminiscences and selections from his private letters to numerous correspondents,

v. 1, 1795-1846 v. 2, 1847-1881.

A pathology of the animal spirits – the clinical neurology of Thomas Willis (1621–1675) Part II – Disorders of intrinsically abnormal animal spirits

Thomas Willis (1621-1675), author of the classical work Cerebri Anatome (1664), was arguably the father of the modern era of neurology. His clinical neurology, as described in his Pathologiae Cerebri (1667) and De Anima Brutorum (1672), was largely derived from personal observations and not from traditional authorities and was based around his concept of the animal spirits, a fictitious entity in many ways analogous to the present day idea of the nerve impulse. This concept allowed him to develop a pathology of the animal spirits which embraced the whole content of the clinical neurology and psychiatry of his times. The anatomical and physiological background to Willis' concepts of animal spirit dysfunction, and those disorders he regarded as due to disturbed function of intrinsically normal animal spirits, have been dealt with in the previous part of this paper. The disorders he attributed to intrinsically abnormal animal spirits, dealt with in this part of the paper, comprised two categories. In one, the animal spirits possessed explosive properties, whilst in the other the abnormalities were non-explosive in their nature. The former category included epilepsy, hysteria and hypochondriasis, whilst the latter included mainly disorders now considered psychiatric e.g. delirium, melancholy, madness and stupidity. Willis' ideas about the pathogenesis of nervous system disorder seem never to have been generally accepted, partly because they appeared at a time when others were increasingly calling into question the existence of the animal spirits. Nevertheless, Willis' attempt to record and interpret all nervous system disease on the basis of disorder of function of a single underlying mechanism represents a formidable synthetic intellectual endeavour on the part of a very busy physician. (C) 2002 Elsevier Science Ltd. All rights reserved.

Serum procalcitonin and C-reactive protein as markers of sepsis and outcome in patients with neurotrauma and subarachnoid haemorrhage

This prospective study evaluated serum procalcitonin (PCT) and C-reactive protein (CRP) as markers for systemic inflammatory response syndrome (SIRS)/sepsis and mortality in patients with traumatic brain injury and subarachnoid haemorrhage. Sixty-two patients were followed for 7 days. Serum PCT and CRP were measured on days 0, 1, 4, 5, 6 and 7. Seventy-seven per cent of patients with traumatic brain injury and 83% with subarachnoid haemorrhage developed SIRS or sepsis (P= 0.75). Baseline PCT and CRP were elevated in 35% and 55% ofpatients respectively (P=0.03). There was a statistically non-significant step-wise increase in serum PCT levels from no SIRS (0.4 +/- 0.6 ng/ml) to SIRS (3.05 +/- 9.3 ng/ml) to sepsis (5.5 +/- 12.5 ng/ml). A similar trend was noted in baseline PCT in patients with mild (0.06 +/- 0.9 ng/ml), moderate (0.8 +/- 0.7 ng/ml) and severe head injury (1.2 +/- 1.9 ng/ml). Such a gradation was not observed with serum CRP There was a non-significant trend towards baseline PCT being a better marker of hospital mortality compared with baseline CRP (ROC-AUC 0.56 vs 0.31 respectively). This is the first prospective study to document the high incidence of SIRS in neurosurgical patients. In our study, serum PCT appeared to correlate with severity of traumatic brain injury and mortality. However, it could not reliably distinguish between SIRS and sepsis in this cohort. This is in pan because baseline PCT elevation seemed to correlate with severity of injury. Only a small proportion ofpatients developed sepsis, thus necessitating a larger sample size to demonstrate the diagnostic usefulness of serum PCT as a marker of sepsis. Further clinical trials with larger sample sizes are required to confirm any potential role of PCT as a sepsis and outcome indicator in patients with head injuries or subarachnoid haemorrhage.

A pathology of the animal spirits - the clinical neurology of Thomas Willis (1621-1675) Part I - Background, and disorders of intrinsically normal animal spirits

Thomas Willis (1621-1675), author of the classical work Cerebri Anatome (1664), was arguably the father of the modem era of neurology. As compared with his neuroanatomy, relatively little attention has been paid to Willis' clinical neurology, as described in his Pathologiae Cerebri (1667) and Do Anima Brutorum (1672), where he gave a structured account of disease of the nervous system as it was known in his day. His account was largely derived from personal observations and not from traditional authorities and was based around his concept of the animal spirits, a fictitious entity in many ways analogous to the present day idea of the nerve impulse. This concept allowed him to develop a pathology of the animal spirits which embraced the whole content of the clinical neurology and psychiatry of his times. The anatomical and physiological background to Willis! concepts of animal spirit dysfunction, and those disorders he regarded as due to disturbed function of intrinsically normal animal spirits (mainly headache, disorders of consciousness, apoplexy and palsy) are dealt with in the present paper. The disorders he attributed to inherently abnormal animal spirits are considered in a second part of the paper. (C) 2002 Elsevier Science Ltd. All eights reserved.