Baserrietara egindako eskola bisitak: lehen hezkuntzarako material didaktikoen diseinua, ezarpena eta ebaluazioa

58 p.

Restricciones de igualdad sobre el dominio de los naturales

El objetivo de este proyecto consiste en implementar una aplicación que busca todos los modelos de una fórmula recibida como entrada. Esta fórmula de entrada pertenece a la lógica NatEq, la cual es un subconjunto de la lógica de primer orden. Esta lógica consta de un sólo predicado, que es la igualdad. Además, no contiene símbolos de funciones, incluye los cuantificadores universal y existencial, y se interpreta sobre el dominio de los números naturales N.

On the Dynamics of the Adenylate Energy System: Homeorhesis vs Homeostasis

Biochemical energy is the fundamental element that maintains both the adequate turnover of the biomolecular structures and the functional metabolic viability of unicellular organisms. The levels of ATP, ADP and AMP reflect roughly the energetic status of the cell, and a precise ratio relating them was proposed by Atkinson as the adenylate energy charge (AEC). Under growth-phase conditions, cells maintain the AEC within narrow physiological values, despite extremely large fluctuations in the adenine nucleotides concentration. Intensive experimental studies have shown that these AEC values are preserved in a wide variety of organisms, both eukaryotes and prokaryotes. Here, to understand some of the functional elements involved in the cellular energy status, we present a computational model conformed by some key essential parts of the adenylate energy system. Specifically, we have considered (I) the main synthesis process of ATP from ADP, (II) the main catalyzed phosphotransfer reaction for interconversion of ATP, ADP and AMP, (III) the enzymatic hydrolysis of ATP yielding ADP, and (IV) the enzymatic hydrolysis of ATP providing AMP. This leads to a dynamic metabolic model (with the form of a delayed differential system) in which the enzymatic rate equations and all the physiological kinetic parameters have been explicitly considered and experimentally tested in vitro. Our central hypothesis is that cells are characterized by changing energy dynamics (homeorhesis). The results show that the AEC presents stable transitions between steady states and periodic oscillations and, in agreement with experimental data these oscillations range within the narrow AEC window. Furthermore, the model shows sustained oscillations in the Gibbs free energy and in the total nucleotide pool. The present study provides a step forward towards the understanding of the fundamental principles and quantitative laws governing the adenylate energy system, which is a fundamental element for unveiling the dynamics of cellular life.

Methods and tools for the assessment of daylight transmittance through expanded metal meshes

306 p.

Proficiency, Attitude and Conventions in Minority Languages

In this paper we study a simple mathematical model of a bilingual community in which all agents are f luent in the majority language but only a fraction of the population has some degree of pro ficiency in the minority language. We investigate how different distributions of pro ficiency, combined with the speaker´attitudes towards or against the minority language, may infl uence its use in pair conversations.

Justicia penal restaurativa y justicia penal negociada, retórica y práctica. Estudio empírico del programa de mediación intrajudicial penal en Bizkaia

633 p.

Fresadora C.N.C. de tres ejes

Tras la aparición de Arduino en el año 2002, emergió un fuerte movimiento concienciado con las plataformas libres, tanto en software como en hardware. Este movimiento junto con la filosofía del hágalo usted mismo (Do It Yourself) hizo que surgieran un sin fin de proyectos de todas las índoles, desde proyectos simples, como robots cartesianos, hasta proyecto más serios, como puede ser una máquina de control numérico. Todo esto es posible ya que junto con Arduino, han surgido infinidad de complementos y sensores asociados, fáciles de conseguir, baratos y que hacen que casi cualquier proyecto sea fácil de llevar a cabo y además económicamente viable. Lo que el autor de este proyecto fin de grado quiere hacer llegar al lector, es que un proyecto tan abrumador como puede ser una máquina de control numérico, puede ser perfectamente factible gracias a las bondades de una placa de un precio ínfimo y el ecosistema generado en torno a él.

Coherencia de Políticas para el Desarrollo en Euskadi: diagnóstico y propuestas

Resumen ejecutivo en euskera, inglés y español. Informe completo en español

Interacciones entre las células madre pluripotentes del carcinoma embrionario y las células mioides peritubulares del testículo

112 p.+ anexos

Frecuencia de la extensión etmoidal de la sinusitis maxilar odontógena y respuesta al tratamiento quirúrgico

126 p.

Factores y condiciones de la formación del jugador de fútbol en Bogotá

280 p.

Las víctimas y el jurado: análisis de algunos sesgos como factores explicativos del veredicto

El presente TFG es un estudio de investigación enfocado a analizar los factores socio-demográficos y psicosociales que pueden tener un impacto o influencia significativos en los veredictos emitidos por el Tribunal del Jurado. Partiendo de un marco teórico actualizado con respecto al tema, se ahonda en la parte empírica en ocho factores susceptibles de estudio,analizando su interacción en sentencias de la Audiencia Provincial de Gipuzkoa y poniéndolos en relación con estudios previos a este respecto.

Perinatal hipoxic ischemic injury in the auditory pathway and the effect of several neuroprotective agents

192 p.

Bipolar disorder comorbid with alcohol use disorder: Focus on neurocognitive correlates

Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more severe neurocognitive deficits than those with a single diagnosis, but there is paucity of research in this area. To explore this hypothesis more thoroughly, we carried out a systematic literature review through January 2015. Eight studies have examined the effect of AUDs on the neurocognitive functioning of BD patients. Most studies found that BD patients with current or past history of comorbid AUDs show more severe impairments, especially in verbal memory and executive cognition, than their non-dual counterparts. Greater neurocognitive dysfunction is another facet of this severe comorbid presentation. Implications for clinical practice and research are discussed. Specifically, the application of holistic approaches, such as clinical staging and systems biology, may open new avenues of discoveries related to the BD-AUD comorbidity.

The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population

We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population (Basques from the North of Spain) and by resequencing the whole coding region and intron 5 of the 34 most and the 34 least pigmented individuals according to the reflectance distribution, we observed that the polymorphism Leu374Phe (L374F, rs16891982) was statistically associated with skin color variability within this sample. In particular, allele 374F was significantly more frequent among the individuals with lighter skin. Further genotyping an independent set of 558 individuals of a geographically wider population with known ancestry in the Spanish population also revealed that the frequency of L374F was significantly correlated with the incident UV radiation intensity. Selection tests suggest that allele 374F is being positively selected in South Europeans, thus indicating that depigmentation is an adaptive process. Interestingly, by genotyping 119 melanoma samples, we show that this variant is also associated with an increased susceptibility to melanoma in our populations. The ultimate driving force for this adaptation is unknown, but it is compatible with the vitamin D hypothesis. This shows that molecular evolution analysis can be used as a useful technology to predict phenotypic and biomedical consequences in humans.