997 resultados para Lockhart, Norman James Alexander Macdonald, 1884-1974
Resumo:
Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study, we show that Notch signaling in T cells is a major player in the development and function of TFH cells. T cell-specific gene ablation of Notch1 and Notch2 impaired differentiation of TFH cells in draining lymph nodes of mice immunized with T-dependent Ags or infected with parasites. Impaired TFH cell differentiation correlated with deficient germinal center development and the absence of high-affinity Abs. The impact of loss of Notch on TFH cell differentiation was largely independent of its effect on IL-4. These results show a previously unknown role for Notch in the regulation of TFH cell differentiation and function with implications for the control of this T cell population.
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This summary of legislation enacted by the General Assembly has been prepared for the use of legislators and other interested parties. The summary of each legislative enactment has been assigned to a major subject category. This compilation provides interested persons with quick reference to legislation enacted in specific areas and generally informs persons of the contents and effective date of the legislation. NOTE: This is a large file and may take a few minutes to load.
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To address safety concerns on James Avenue NW and 250th Street NW, from the North Corporate Limits (NCL) of Tiffin, north and east to I-380 (at North Liberty), the Johnson County engineer requested a road safety audit (RSA). The audit was conducted on September 1, 2010, through a program supported by the Office of Traffic and Safety at the Iowa Department of Transportation (DOT). This road is a seal-coated roadway, about 25-ft wide, but with only about 0-1 ft of earth shoulders. According to 2006 Iowa DOT estimates, traffic volume is about 820 vehicles per day, north from Tiffin to a commercial entrance on 250th Street, then increasing to 2,990 vehicles per day to the on-ramp of Interstate 380 (I-380). Local traffic uses this road as a short-cut to Cedar Rapids, North Liberty, and the I-380/I-80 interchange (to avoid congestion on IA 965). This report outlines the findings and recommendations of the road safety audit team for addressing the safety concerns on this roadway.
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This is the statistical portion of the annual survey results of the State Library of Iowa for 1974.
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This report is a study of the costs, benefits and impacts of dredging programs for eight Iowa Lakes: Backbone Lake, Black Hawk Lake, Blue Lake, Five Island Lake, Lake Manawa, Mill Creek Lake, Rock Lake and Silver Lake. The studies were done by Economics Research Associates (ERA) and Engineering Consultants, Inc. (ECI) and was commissioned by the Iowa General Assembly to assist in determining public policy with respect to the dredging of the subject lakes.
Resumo:
Carcinoembryonic antigen (CEA) was purified from primary tumour or from hepatic metastases obtained from ten cases of carcinoma of the colon. In nine cases the blood group antigens A, B, Lea or Leb were detected in CEA preparations by the binding of 125I-labelled CEA by blood group antibodies. The extent of binding appeared to preclude simple contamination of CEA preparations by blood group glycoprotein. In all cases the blood group antigens detected were consistent with the patients' known blood groups. Blood group I and i activities were not detected. It is concluded that the determinants of A, B and Lewis antigens and of CEA share the same glycoprotein carrier molecules.
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30 janvier 1884 : Lui demande de remettre son billet à la fin du mois suivant. - 18 mars 1884 : Lui demande une avance de 1000 francs pour "Loreley"
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Capítol 12 de 'Josep Carner: l'exili del mite (1945-1970)', sobre el llibre pòstum de refranys i aforismes 'Proverbis d'ací i d'allà' (1974).
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Zusammenfassung: Kirchenpolitik einer Partei oder von Erweckungsbewegungen? : die Entwicklung der Kirchenpolitik der finnischen Zentrumspartei 1973 und 1974
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Collection : Journal officiel de la République française ; brochure 1002