Ant. Iosephi Cavanilles Icones et descriptiones plantarum, quae aut sponte in Hispania crescunt, aut in hortis hospitantur [Texto impreso] : volumen IV

Hay 1 ejemp. encuadernado con: Ant. Iosephi Cavanilles Icones et descriptiones plantarum, quae aut sponte in Hispania crescunt, aut in hortis hospitantur : volumen III (XVIII/2465)

Ant. Iosephi Cavanilles Icones et descriptiones plantarum, quae aut sponte in Hispania crescunt, aut in hortis hospitantur [Texto impreso] : volumen V.

Sign. : []1, [calderón]3, B-T2

Ant. Iosephi Cavanilles Icones et descriptiones plantarum, quae aut sponte in Hispania crescunt, aut in hortis hospitantur [Texto impreso] : volumen VI

Hay 1 ejemp. encuadernado con: Ant. Iosephi Cavanilles Icones et descriptiones plantarum, quae aut sponte in Hispania crescunt, aut in hortis hospitantur : volumen V (XVIII/2466)

[Colección de grabados con planos, detalles y cortes de monumentos españoles] [Material gráfico]

Contiene: Detalles y Cortes de los Templos en TALAVERA la Vieja / Moulinier del. ; N. L. Rousseau sculp. Plano del Monasterio de JUSTE / Moulinier del. ; Kamermann sculp. Plano del Alcazar de la ALAMBRA. Plano del GENERALIFE de GRENADA [sic] / Thierry scup. Plano de los Baños de ALHANGE / Moulinier del. ; Vicq sculp. Plano de la Mezquita de CORDOVA segun su estado actual / Moulinier del. ; [...]. Plano de la Mezquita de CORDOVA en tiempo de los Arabes / Dormier sculp.t

Catàlec bibliogràfic de la prensa valenciana [Texto impreso] : escrita en nostra llengua y publicada en Valencia _ : 1586-1927

Índices

Voyage d' Espagne, curieux, historique et politique fait l' Anne 1655. Relation de Madrid [Texto impreso]

Según Palau, XXVIII, 372950, el autor es Antoine de Brunel

[Retrato de un hombre] [ [Material gráfico].]

Sumario: Figura de hombre de tres cuartos sentado, con las piernas cruzadas, el brazo derecho apoyado en una mesa, y un libro entre las manos, mirando a cámara.

[Retrato de mujer] [ [Material gráfico].]

Sumario: Figura de mujer de tres cuartos de pie, con las manos entrelazadas, mirando a cámara.

[Retrato de mujer con niña] [ [Material gráfico].]

Sumario: Figura de mujer de tres cuartos sentada, a su lado posa de pie una niña de corta edad, las dos mirando a cámara.

[Retrato de dos niñas] [ [Material gráfico].]

Sumario: Figura de una niña de tres cuartos sentada, el brazo derecho apoyado en una mesa cubierta por una tela y en la mano izquierda tiene un libro, sobre su hombro derecho reposa la mano de la otra niña que posa de pie a su lado, mirando a cámara.

[Retrato de un caballero] [ [Material gráfico].]

Sumario: Figura de hombre de tres cuartos sentado, con las piernas cruzadas, el brazo derecho apoyado en una mesa y el izquierdo sobre su pierna, mirando a cámara.

SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia

Retinoic acid receptors (RARs) are hormone-regulated transcription factors that control key aspects of normal differentiation. Aberrant RAR activity may be a causal factor in neoplasia. Human acute promyelocytic leukemia, for example, is tightly linked to chromosomal translocations that fuse novel amino acid sequences (denoted PML, PLZF, and NPM) to the DNA-binding and hormone-binding domains of RARα. The resulting chimeric receptors have unique transcriptional properties that may contribute to leukemogenesis. Normal RARs repress gene transcription by associating with ancillary factors denoted corepressors (also referred to as SMRT, N-CoR, TRAC, or RIP13). We report here that the PML-RARα and PLZF-RARα oncoproteins retain the ability of RARα to associate with corepressors, and that this corepressor association correlates with certain aspects of the leukemic phenotype. Unexpectedly, the PLZF moiety itself can interact with SMRT corepressor. This interaction with corepressor is mediated, in part, by a POZ motif within PLZF. Given the presence of POZ motifs in a number of known transcriptional repressors, similar interactions with SMRT may play a role in transcriptional silencing by a variety of both receptor and nonreceptor transcription factors.

Metabolism to a response pathway selective retinoid ligand during axial pattern formation

We report identification of 9-cis-4-oxo-retinoic acid (9-cis-4-oxo-RA) as an in vivo retinoid metabolite in Xenopus embryos. 9-Cis-4-oxo-RA bound receptors (RARs) α, β, and γ as well as retinoid X receptors (RXRs) α, β, and γ in vitro. However, this retinoid displayed differential RXR activation depending on the response pathway used. Although it failed to activate RXRs in RXR homodimers, it activated RXRs and RARs synergistically in RAR-RXR heterodimers. 9-Cis-4-oxo-RA thus acted as a dimer-specific agonist. Considering that RAR-RXR heterodimers are major functional units involved in transducing retinoid signals during embryogenesis and that 9-cis-4-oxo-RA displayed high potency for modulating axial pattern formation in Xenopus, metabolism to 9-cis-4-oxo-RA may provide a mechanism to target retinoid action to this and other RAR-RXR heterodimer-mediated processes.