938 resultados para Library of Congress. National Library Service for the Blind and Physically Handicapped.
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Includes a "chap. xlv. State papers, laws, journals, &c."
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Mode of access: Internet.
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Includes index.
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"Selected bibliography": p.194-196. Bibliographical "Notes": p.197-229.
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Vols. 1-4, compiled under the direction of P. L. Phillips, chief. Division of Maps and Charts; v. 5- by C.E. LeGear.
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Vols. 1-4, compiled under the direction of P. L. Phillips, chief, Division of Maps and Charts; v. 5-6, by C. E. LeGear, Map Division (v. 7-8, Geography and Map Division)
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Mode of access: Internet.
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Mode of access: Internet.
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Accompanied by "Supplement. 1949-51." (19 p. 26 cm.) Published: Washington, 1952.
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Mode of access: Internet.
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Mode of access: Internet.
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Introduction: Mutation testing for the MEN1 gene is a useful method to diagnose and predict individuals who either have or will develop multiple endocrine neoplasia type 1 ( MEN 1). Clinical selection criteria to identify patients who should be tested are needed, as mutation analysis is costly and time consuming. This study is a report of an Australian national mutation testing service for the MEN1 gene from referred patients with classical MEN 1 and various MEN 1- like conditions. Results: All 55 MEN1 mutation positive patients had a family history of hyperparathyroidism, had hyperparathyroidism with one other MEN1 related tumour, or had hyperparathyroidism with multiglandular hyperplasia at a young age. We found 42 separate mutations and six recurring mutations from unrelated families, and evidence for a founder effect in five families with the same mutation. Discussion: Our results indicate that mutations in genes other than MEN1 may cause familial isolated hyperparathyroidism and familial isolated pituitary tumours. Conclusions: We therefore suggest that routine germline MEN1 mutation testing of all cases of classical'' MEN1, familial hyperparathyroidism, and sporadic hyperparathyroidism with one other MEN1 related condition is justified by national testing services. We do not recommend routine sequencing of the promoter region between nucleotides 1234 and 1758 ( Genbank accession no. U93237) as we could not detect any sequence variations within this region in any familial or sporadic cases of MEN1 related conditions lacking a MEN1 mutation. We also suggest that testing be considered for patients < 30 years old with sporadic hyperparathyroidism and multigland hyperplasia
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It is no secret that computer services came to revolutionize the world. More than a service, have since become an indispensable tool for humanity, because they simplify and make life easier in many of his orders, through its various support options. These advances are added Internet services, so that by the mid 1980's assessed the need for such a research tool in order to apply it in various fields of human knowledge.This research, based on the use and quality of documentary information from the Internet, with application to the students of the Universidad Nacional, Costa Rica, if the Library Board Laboratory Joaquin Garcia Monge, develops in the form of theses.
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v.81 (1983)
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v.91 (1993)