[Certificate of admission of W. P. Alexander], 1866 July 17

Printed copy of an abstract of laws and regulations, and the certificate of admission of undergraduate W. P. Alexander signed by President Thomas Hill on July 17, 1866.

Samuel Hazlet puts in his place James Duane his attorney against Thomas Dignel in a plea of trespass against the case, 1757

Title from verso.

Diary of Thomas Marsh, 1751

Diary kept in an interleaved almanac from 1751. Entries in the diary are brief and sporadic, recording events including travel, visitors, weather, sermons heard, holidays, illnesses and deaths. Occasional expenses are noted, including ones for hay, cider, bottles, shoes, and doctoring. A few dates of college events are noted, including the semi-annual Corporation meeting and Commencement. On the last page is a list of student names, presumably those tutored by Marsh.

Enchiridion ethicum ad theses contractiores redactum in usum pupillorum, p. D. J. L., 1694

Forty-six-page notebook in modern hardcover binding containing John Leverett's edited version of Henry More's "Enchiridion ethicum" transcribed in Latin in 1694. The last page of the document includes entries in Leverett's hands: "Colom // January 17 1690/1," "Winth // January 31 1692/3", and "Vaug // Marty 10 1695/6." The inscriptions and notes likely refer to Benjamin Colman (Harvard AB 1692), Adam Winthrop (Harvard AB 1694), and George Vaughn (Harvard AB 1696).

Student mathematical notebook of Thomas Noyes, 1793

This sewn volume contains Noyes’ mathematical exercises in geometry; trigonometry; surveying; measurement of heights and distances; plain, oblique, parallel, middle latitude, and mercator sailing; and dialing. Many of the exercises are illustrated by carefully hand-drawn diagrams, including a mariners’ compass and moon dials.

Extract from Norwich proprietor's book of records, p. 112, ca. 1775?

Record of parcel of lands in Norwich, CT deeded to a group of individuals including many members of the same families around 1770.

Student essay composed by Thomas Mason, 1796

Three-page folio-sized handwritten student essay composed by Thomas Mason as a Harvard undergraduate. The verso of the last page is inscribed "Mason February 1796." A quotation from Edward Young appears at the top of the first page: "Heaven gives us friends to bless the present science; / Resumes them, to prepare us for the rest." The essay discusses friendship and the death of friends, and begins, "The author of our nature has so constituted it, that pleasure is unknown without the intervention of pain."

Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid

Sterile immunity against malaria can be achieved by the induction of IFNgamma-producing CD8(+) T cells that target infected hepatocytes presenting epitopes of the circumsporozoite protein (CSP). In the present study we evaluate the protective efficacy of a heterologous prime/boost immunization protocol based on the delivery of the CD8(+) epitope of Plasmodium berghei CSP into the MHC class I presentation pathway, by either a type III secretion system of live recombinant Salmonella and/or by direct translocation of a recombinant Bordetella adenylate cyclase toxoid fusion (ACT-CSP) into the cytosol of professional antigen-presenting cells (APCs). A single intraperitoneal application of the recombinant ACT-CSP toxoid, as well as a single oral immunization with the Salmonella vaccine, induced a specific CD8(+) T cell response, which however conferred only a partial protection on mice against a subsequent sporozoite challenge. In contrast, a heterologous prime/boost vaccination with the live Salmonella followed by ACT-CSP led to a significant enhancement of the CSP-specific T cell response and induced complete protection in all vaccinated mice.

The Holy Bible, containing the Old and New Testaments, with copious marginal references : also, the introductions to all the books and chapters in the Bible : with the general preface, as affixed to the commentary of Thomas Scott.

New Testament has special t.p.: The New Testament of our Lord and Saviour Jesus Christ : with copious marginal references by Thomas Scott.

The works of Thomas Middleton, now first collected,

Imperfect: frontpiece wanting. cf. v.1, p. 4211.

The American solution : origins of the U.S. Constitution : an exhibition at the Library of Congress Great Hall of the Thomas Jefferson Building, May 14 through September 17, 1987.

Mode of access: Internet.