Polimorfismos nos genes IL-2, IL-5, IL-8, IL-12 e IFN-y e a resposta a nematoides gastrintestinais em caprinos.

Resumo: Cinco genes candidatos foram selecionados para identificar polimorfismos de nucleotídeo único e sua associação com a resposta de caprinos a nematoides gastrintestinais. Para isso, o DNA genômico dos animais mais resistentes e mais susceptíveis foi extraído e submetido ao sequenciamento de nova geração. Foram observados 71 SNPs, sendo 4 associados à resistência, o que os tornam alvos de estudos em toda a população de caprinos a fim de se confirmar essa associação. [Polymorphisms in IL-2, IL-5, IL-8, IL-12 e IFN-y genes and the response to gastrointestinal nematode in goats]. Abstract: Five candidate genes were selected to identify single nucleotide polymorphisms and its association with goat response to gastrointestinal nematodes. Genomic DNA from resistant and susceptible animals was extracted and submitted to new generation sequencing. It was observed 71 SNPs with 4 associated with resistance, which make them targets for studies on the entire population goats in order to confirm this association.

Natural hydraulic lime (nhl3.5) mortars with scrap tire rubber

The use of wastes and industrial by-products as building materials is an important issue in order to decrease costs with waste management and the embodied energy of building products. In this study scrap tire rubber was used as additional aggregate of mortars based on natural hydraulic lime NHL 3.5 and natural sand. Different particle size fractions and proportions of scrap tire rubber were used: a mix obtained directly from industry and separated fine, medium and coarse fractions; 0 %, 18 %, 36 % and 54 % of the weight of binder, corresponding to 2.5 %, 5 % and 7.5 % of the weight of sand. As mortars based on NHL specifications became stricter with the current version of EN 459–1:2015, the influence of the rubber’s additions on the mortars’ fresh state, mechanical and physical performance is presented in this work: flow table consistency, water retention, dynamic elasticity modulus, flexural and compressive strength, open porosity and bulk density, capillary absorption, drying and thermal conductivity are studied. The use of the rubber mix coming from the waste tire industry seems advantageous and may open possibilities for use as raw material by the mortars industry.

Centrality and rapidity dependence of inclusive jet production in sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Measurements of the centrality and rapidity dependence of inclusive jet production in sNN−−−√=5.02 TeV proton--lead (p+Pb) collisions and the jet cross-section in s√=2.76 TeV proton--proton collisions are presented. These quantities are measured in datasets corresponding to an integrated luminosity of 27.8 nb−1 and 4.0 pb−1, respectively, recorded with the ATLAS detector at the Large Hadron Collider in 2013. The p+Pb collision centrality was characterised using the total transverse energy measured in the pseudorapidity interval −4.9<η<−3.2 in the direction of the lead beam. Results are presented for the double-differential per-collision yields as a function of jet rapidity and transverse momentum (pT) for minimum-bias and centrality-selected p+Pb collisions, and are compared to the jet rate from the geometric expectation. The total jet yield in minimum-bias events is slightly enhanced above the expectation in a pT-dependent manner but is consistent with the expectation within uncertainties. The ratios of jet spectra from different centrality selections show a strong modification of jet production at all pT at forward rapidities and for large pT at mid-rapidity, which manifests as a suppression of the jet yield in central events and an enhancement in peripheral events. These effects imply that the factorisation between hard and soft processes is violated at an unexpected level in proton--nucleus collisions. Furthermore, the modifications at forward rapidities are found to be a function of the total jet energy only, implying that the violations may have a simple dependence on the hard parton--parton kinematics.

Ferroelectric phase transitions studies in 0.5Ba(Zr0.2Ti0.8) O3-0.5(Ba0.7Ca0.3)TiO3 ceramics

The ferroelectric phase transitions in 0.5Ba(Zr0.2Ti0.8)O3-0.5(Ba0.7Ca0.3)TiO3 (BCZT 50/50) ceramics,fabricatedbyasolidstatereaction,werestudiedbyusing X-Ray diffraction, Raman spectroscopy, and measuring electric polarization, dielectric permittivity and pyroelectric current. Xraydiffraction(XRD)confirmsthecoexistenceoftetragonal(T) andrhombohedral(R)phasesatroomtemperature.Thetemperature dependence of the Raman modes frequency reveals the existenceoftwophasetransitionscorrespondingtotherhombohedral – tetragonal, and tetragonal - cubic close to 30 and 100 °C, respectively. The temperature dependence of electric polarization,pyroelectriccurrent,anddielectricpermittivityfurther supports theferroelectric (tetragonal) toparaelectric (cubic) phasetransition.Moreover,thedielectricpermittivityrevealsthe diffuseness of the phase transition and is attributed to the compositional fluctuations of different polar micro-regions.

Measurement of the inclusive jet cross-section in proton--proton collisions at s√=7 TeV using 4.5 fb−1 of data with the ATLAS detector

The inclusive jet cross-section is measured in proton--proton collisions at a centre-of-mass energy of 7 TeV using a data set corresponding to an integrated luminosity of 4.5 fb−1 collected with the ATLAS detector at the Large Hadron Collider in 2011. Jets are identified using the anti-kt algorithm with radius parameter values of 0.4 and 0.6. The double-differential cross-sections are presented as a function of the jet transverse momentum and the jet rapidity, covering jet transverse momenta from 100 GeV to 2 TeV. Next-to-leading-order QCD calculations corrected for non-perturbative effects and electroweak effects, as well as Monte Carlo simulations with next-to-leading-order matrix elements interfaced to parton showering, are compared to the measured cross-sections. A quantitative comparison of the measured cross-sections to the QCD calculations using several sets of parton distribution functions is performed.

Antifungal action of three (Z)-5-amino-N'-aryl-1-methyl-1H-imidazole-4-carbohydrazonamides

[Excerpt] The incidence of fungal infections has greatly increased in patients under sustained immunosuppression with considerable risk associated. Difficulties regarding prompt diagnosis and the limited therapeutic options dictate high mortality rates. Available antifungals display substantial toxicity, a predictable consequence of the cellular structure of the organisms involved, reduced spectrum of activity, and drug interactions. Our group had previously identified three (Z)-5-amino-N'-aryl-1-methyl-1H-imidazole-4-carbohydrazonamides 1 [aryl= phenyl (1a), 4-fluorophenyl (1b), 3fluorophenyl (1c)] as potent antifungal agents.1 (...)

The synthesis of novel 5-aminoimidazoles derivatives with anticancer activity

[Excerpt] The imidazole nucleus is present in a significant number of biomolecules and the inclusion of this moiety in organic scaffolds is considered an important synthetic strategy in drug discovery.[1] 5-Aminoimidazoles are interesting building blocks in medicinal chemistry since they are key components in many bioactive molecules and their derivatives showed a wide pharmacological potential as anticancer drugs.[1] The hydrazones constitute an important class of biological active drug molecules due to their wide range of pharmacological properties that include antitumoral activities.[2] Amidrazone derivatives could be considered very promising in the perspective of new drug discovery, because they are very effective as building blocks to obtain various heterocycles.[2,3] The α-hydrazononitriles are a special case of compounds belonging to the family of hydrazones that is less common in the literature, but has a great interest due to their pharmacological applications.[4] (...)

Sistema reprodutivo e polinização de Lepidagathis sessilifolia (Pohl) Kameyama ex Wassh. & J.R.I. Wood (Acanthaceae), em remanescente florestal da região sudoeste de Mato Grosso, Brasil

O gênero Lepidagathis apresenta distribuição pantropical com cerca de 100 espécies. No Brasil ocorrem 16 espécies, a maioria nas regiões Centro - Oeste e Sudeste. O estudo foi realizado em sub - bosque de remanescente florestal do município de Tangará da Serra - MT e teve como objetivo analisar a fenologia de floração, descrever a morfologia e biologia floral, verificar os visitantes florais e avaliar o sistema e o sucesso reprodutivo por meio de polinizações manuais. Lepidagathis sessilifolia apresenta inflorescências espiciformes, terminais, com cálice de cor rósea vistosa e corola de coloração branco-rósea. A floração ficou restrita aos meses de março a abril, durante a estação chuvosa. A senescência floral ocorreu após 24 ou 48 horas. A viabilidade dos grãos de pólen foi elevada (92,5%). O único polinizador observado visitando as flores de L. sessilifolia foi a abelha Partamona nhambiquara (Apidae - Meliponini). O sistema reprodutivo misto da espécie é caracterizado pela formação de frutos por meio de agamospermia, autopolinização e polinização cruzada. Esse sistema reprodutivo flexível é vantajoso, pois, garante a manutenção da espécie na área de estudo mesmo na ausência de polinizadores.

Erratum to: Measurement of the inclusive jet cross-section in proton-proton collisions at s√=7 TeV using 4.5 fb−1 of data with the ATLAS detector

It was found that the non-perturbative corrections calculated using Pythia with the Perugia 2011 tune did not include the effect of the underlying event. The affected correction factors were recomputed using the Pythia 6.427 generator. These corrections are applied as baseline to the NLO pQCD calculations and thus the central values of the theoretical predictions have changed by a few percent with the new corrections. This has a minor impact on the agreement between the data and the theoretical predictions. Figures 2 and 6 to 13, and all the tables have been updated with the new values. A few sentences in the discussion in sections 5.2 and 9 were altered or removed.

Z boson production in p plus Pb collisions at root S-NN=5.02 TeV measured with the ATLAS detector

The ATLAS Collaboration measures the inclusive production of Z bosons via their decays into electron and muon pairs in p+Pb collisions at sNN−−−√=5.02TeV at the Large Hadron Collider. The measurements are made using data corresponding to integrated luminosities of 29.4 and 28.1 nb−1 for Z→ee and Z→μμ, respectively. The results from the two channels are consistent and combined to obtain a cross section times the Z→ℓℓ branching ratio, integrated over the rapidity region ∣∣y∗Z|<3.5, of 139.8±4.8(statistical)±6.2(systematic)±3.8 (luminosity) nb. Differential cross sections are presented as functions of the Z boson rapidity and transverse momentum and compared with models based on parton distributions both with and without nuclear corrections. The centrality dependence of Z boson production in p+Pb collisions is measured and analyzed within the framework of a standard Glauber model and the model's extension for fluctuations of the underlying nucleon-nucleon scattering cross section.

Ação do mononitrato-5 de isossorbida sublingual durante cinecoronariografia. Comparação com o uso de nitroglicerina sublingual

OBJETIVO: Avaliar o efeito sublingual do mononitrato-5 de isossorbida (MN5IS) e nitroglicerina (NTG) sobre o diâmetro luminal de artérias coronárias epicárdicas, pressão arterial média e efeitos colaterais. MÉTODOS: Cinqüenta pacientes foram submetidos a cateterismo cardíaco e cinecoronariografia, na condição inicial e 5min após administração sublingual de MN5IS grupo A (GA) ou NTG grupo B (GB). RESULTADOS: O diâmetro coronário de referência aumentou em ambos os grupos, sem significância estatística entre os mesmos. Nos GA e GB foram demonstrados uma diminuição (1,66mmHg) e um aumento (0,79mmHg) na pressão arterial média, respectivamente (p=0,123). Não foram observados efeitos colaterais com o uso destas drogas. CONCLUSÃO: MN5IS sublingual é uma alternativa à administração de NTG durante cinecoronariografia e representa uma alternativa terapêutica para o tratamento de doença cardíaca isquêmica.

Síntese e testes in vitro de novas pirimido[5,4-d] pirimidinas em células resistentes do cancro coloretal

Dissertação de mestrado em Química Medicinal

Cinemática e dinâmica de engrenagens - 5. Engrenagens de parafuso sem-fim

[Excerto] 5.1. INTRODUÇÃO As engrenagens de parafuso sem-fim pertencem ao grupo das engrenagens torsas1, em que uma das rodas tem a forma de um parafuso (Branco et al., 2009). As engrenagens de parafuso sem-fim podem também ser consideradas como um caso particular das engrenagens helicoidais cruzadas, sendo que a capacidade de carga é maior no caso do parafuso sem-fim (Flores e Gomes, 2014c). A figura 5.1 ilustra uma engrenagem de parafuso sem-fim com roda helicoidal. Na verdade, esta é uma das formas mais simples e mais frequentemente utilizada na prática corrente e que inclui um parafuso cilíndrico e uma roda cilíndrica de dentes helicoidais, daí a designação de parafuso sem-fim roda helicoidal (Niemann, 1971; Drago, 1988). Na grande maioria das aplicações de parafusos sem-fim o ângulo formado pelos eixos do parafuso e da roda é igual a 90º. As engrenagens de parafuso sem-fim não são, em geral, reversíveis, isto é, funcionam apenas quando o veio motor aciona o parafuso sem-fim, uma vez que quando o sistema é acionado pela roda, a engrenagem tende a bloquear2 (Henriot, 1979; Shigley e Uicker, 1980). (...)

Estudio CLACyD: Lactancia y alimentación, crecimiento y desarrollo en niños de 0 a 5 años de vida, Córdoba

Con el propósito de responder a interrogantes acerca de los perfiles de alimentación y su asociación con los de crecimiento y desarrollo en un núcleo urbano estratificado socialmente, se constituyó en 1992 un equipo interdisciplinario de investigadores, representando a Instituciones Académicas (Facultad de Ciencias Médicas y Ciencias Económicas), de Servicios (Gobiernos Municipal y Provincial) y Sociedades Científicas (de Pediatría y Ginecología). Este equipo elaboró un primer proyecto destinado a estudiar una cohorte infantil desde el nacimiento hasta el año de edad. La propuesta actual es ampliar la delimitación temporal de la investigación, extendiéndola hasta fines de la edad preescolar. Son sus objetivos principales: a) Describir perfiles de lactancia, Introducción de alimentos y Crecimiento y Desarrollo. b) Analizar las relaciones alimentación/crecimiento y desarrollo, atendiendo al origen social, condiciones materiales y familiares de vida, y antecedentes de salud-enfermedad de madres y niños. c) Construir, aplicando el enfoque de riesgo, instrumentos predictivos para actuar con sentido preventivo en salud materno-infantil. Por su estrategia temporal, el diseño de la investigación es de tipo prospectivo; se estudia una cohorte de nacidos en mayo de 1993, en diferentes momentos de sus primeros años de vida. El grupo objeto de estudio se conforma inicialmente con 709 niños y sus madres que completan las condiciones de inclusión. Las etapas cronológicas ya cumplidas corresponden al mes, seis meses y un año de vida. La encuesta del primer mes se completó en 651 binomios y la del año en 575. Las etapas propuestas para la continuación del estudio incluyen mediciones antropométricas, evaluaciones de desarrollo psicomotriz y psicosocial a los 2, 3 y 4 años y registros de la historia alimentaria e información complementaria de carácter biológico, demográfico, familiar, conductual, sociocultural, en todos los momentos de toma de datos. Para la información brindada por la madre se emplean encuestas diseñadas ad-hoc por el equipo de investigación, en consultas con especialistas, según el área de conocimiento involucrada; los Instrumentos son los Formularios que contienen según el caso, preguntas cerradas, abiertas, de selección múltiple, de opinión, en escalas de rango, de actitud, etc. Técnicas medicionales son utilizadas para el registro de los Parámetros Antropométricos y para la evaluación del Desarrollo se aplican pruebas de un Instrumento utilizado en un Estudio Colaborativo Nacional sobre niños de 0 a 5 años. El procesamiento estadístico de la información se realiza en el Instituto de Estadísticas y Demografía de la Facultad de Ciencias Económicas. Se trabaja con el paquete estadístico SPSS y programas ad-hoc confeccionados por el equipo.

¿Murosafuera? locura y desmanicomialización desde el enfoque de derechos humanos. contextualización y análisis de la ley provincial nº 9848 de “protección de la salud mental” promulgada en córdoba el 5 de noviembre de 2010.

El proyecto de investigación se propone el análisis de la Ley 9848 de “Protección de Salud Mental” promulgada en la Provincia de Córdoba a fines del 2010. En ese sentido, se aborda el enfoque de derechos humanos y su contribución al nuevo paradigma de salud mental presente en esa Ley; así como también el movimiento de desmanicomialización, en cuanto anclaje teórico de la misma. Todo lo anterior con el objetivo central de revisar la currícula de la formación de grado de la carrera de psicología en la Facultad de Filosofía y Humanidades de la Universidad Católica de Córdoba, a fin de proponer las transformaciones pertinentes y la posibilidad de una presencia transversal y como contenido específico de esta Ley en ese plan de carrera; toda vez que la hipótesis de trabajo formulada anticipa su ausencia y postula que sólo mediante esta imbricación entre la nueva Ley y la currícula de los alumnos, se logrará formar profesionales capaces de comprender y actuar en base a las profundas implicancias de esta normativa en la práctica profesional de la salud pública. Para propender al cumplimiento de ese propósito, el proyecto examina las concepciones teóricas sobre los procesos de salud-enfermedad; la evolución histórica de la política social sobre salud mental en Argentina; las experiencias nacionales e internacionales de desmanicomialización, y sistematiza los aportes teóricos de Michel Foucault sobre la locura, que sirven de sustento teórico al movimiento social de desmanicomialización.