Die Geschichten der heiligen Schriften mit vielen Nutzanwendungen für die jisraelitische Jugend jedes Alters in Schule und Haus : mit 1 Zeittaf. u. 1 Charte d. heiligen Landes

von J. H. Hirsch

Kulturdefizit am Ende des 19. Jahrhunderts

von Marcus Hirsch

Das ‹Evangelium der Natur› oder: Was hat der Pelikan mit Christus zu tun?, Eine theologische Vortragsreihe. Begleitprogramm zu «Sprachen, Schriften, Zeichen»

Anhand einer über 1000 Jahre alten Berner Handschrift tauchen die Besucherinnen und Besucher sinnlich in die Welt christlicher Natursymbolik ein (Poster).

Nachricht von der Lehr- und Bildungsanstalt für Söhne jüdischer Familien

von M. H. Bock

Dat moseh we jsrael : die mosaisch-rabbinische Religionslehre : katechet. f. d. Unterricht bearb.

von Hirsch B. Fassel

Lehrbuch der israelitischen Religion : nach den Quellen bearbeitet ; zum Gebrauch in den oberen Klassen der Religionsschulen ; mit sehr wichtigen erl. Anmerkungen für Eltern, Lehrer, angehende Theologen

von B. H. Auerbach

Die wichtigsten Institutionen des Judenthums nach der Bibel, dem Talmud und den Aussprüchen der Weisen in Israel

dargest. von M. H. Friedländer

Die Humanität als Religion : in Vorträgen, gehalten in der Loge zu Luxemburg

von Samuel Hirsch

Influence of IFNL3/4 polymorphisms on the incidence of cytomegalovirus infection after solid-organ transplantation

BACKGROUND  Polymorphisms in the interferon-λ (IFNL) 3/4 region have been associated with reduced hepatitis C virus clearance. We explored the role of such polymorphisms on the incidence of CMV infection in solid-organ transplant (SOT) recipients. METHODS  Caucasian patients participating in the Swiss Transplant Cohort Study in 2008-2011 were included. A novel functional TT/-G polymorphism (rs368234815) in the CpG region upstream of IFNL3 was investigated. RESULTS  A total of 840 SOT recipients at risk for CMV were included, among whom 373 (44%) received antiviral prophylaxis. The 12-months cumulative incidence of CMV replication and disease were 0.44 and 0.08, respectively. Patient homozygous for the minor rs368234815 allele (-G/-G) tended to have a higher cumulative incidence of CMV replication (SHR=1.30 [95%CI 0.97-1.74], P=0.07) compared to other patients (TT/TT or TT/-G). The association was significant among patients followed by a preemptive approach (SHR=1.46 [1.01-2.12], P=0.047), especially in patients receiving an organ from a seropositive donor (D+, SHR=1.92 [95%CI 1.30-2.85], P=0.001), but not among those who received antiviral prophylaxis (SHR=1.13 [95%CI 0.70-1.83], P=0.6). These associations remained significant in multivariate competing risk regression models. CONCLUSIONS  Polymorphisms in the IFNL3/4 region influence susceptibility to CMV replication in SOT recipients, particularly in patients not receiving antiviral prophylaxis.

IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid Organ Transplantation.

BACKGROUND  Single nucleotide polymorphisms (SNPs) in immune genes have been associated with susceptibility to invasive mold infection (IMI) among hematopoietic stem cell (HSCT) but not solid organ transplant (SOT) recipients. METHODS  24 SNPs from systematically selected genes were genotyped among 1101 SOT recipients (715 kidneys, 190 liver, 102 lungs, 79 hearts, 15 other) from the Swiss Transplant Cohort Study. Association between SNPs and the endpoint were assessed by log-rank test and Cox regression models. Cytokine production upon Aspergillus stimulation was measured by ELISA in PBMCs from healthy volunteers and correlated with relevant genotypes. RESULTS  Mold colonization (N=45) and proven/probable IMI (N=26) were associated with polymorphisms in interleukin-1 beta (IL1B, rs16944; log-rank test, recessive mode, colonization P=0.001 and IMI P=0.00005), interleukin-1 receptor antagonist (IL1RN, rs419598; P=0.01 and P=0.02) and β-defensin-1 (DEFB1, rs1800972; P=0.001 and P=0.0002, respectively). The associations with IL1B and DEFB1 remained significant in a multivariate regression model (IL1B rs16944 P=0.002; DEFB1 rs1800972 P=0.01). Presence of two copies of the rare allele of rs16944 or rs419598 was associated with reduced Aspergillus-induced IL-1β and TNFα secretion by PBMCs. CONCLUSIONS  Functional polymorphisms in IL1B and DEFB1 influence susceptibility to mold infection in SOT recipients. This observation may contribute to individual risk stratification.

Das Schächten : eine vorläufige Auseinandersetzung

von Hirsch Hildesheimer

Systematischer Katechismus der israelitischen Religion : auf Beschluß des Vorstandes der israelitischen Gemeinde zu Luxemburg

hrsg. von Samuel Hirsch

Ankläger und Vertheidiger des Talmud

nach e. Vortr. von H. Goitein

Das System der religiösen Anschauung der Juden und sein Verhältniß zum Heidenthum, Christenthum und zur absoluten Philosophie : für Theologen aller Konfessionen so wie f. gebildete Nichtheologen dargest. u. mit d. erl. Beweisstellen aus d. heil. Schrift, d. Talmudim u. Midraschim vers.

von Samuel Hirsch

Das Licht! : Verf. u. vorgetr. zur 2000 jährigen Chanuka-Feier ...

von Hirsch Berend Cohen