Necrotizing soft tissue infection of the breast: Case report and literature review

Background: Necrotizing soft tissue infection (NSTI) is characterized by progressive infectious gangrene of the skin and subcutaneous tissue. Its treatment involves intensive care, broad-spectrum antibiotic therapy, and full debridement. Methods: We present two cases of NSTI of the breast, adding these cases to the 14 described in the literature, reviewing the characteristics and evolution of all cases. Case Report: On the fourth day after mastectomy, a 59-year-old woman with ulcerated breast cancer developed Type I NSTI caused by Pseudomonas aeruginosa, which had a favorable evolution after debridement and broad-spectrum antibiotics. The second patient was a 57-year-old woman submitted to a mastectomy and axillary dissection, who had recurrent seromas. On the 32nd post-operative day, after a seroma puncture, she developed Type II NSTI caused by β-hemolytic streptococci. She developed sepsis and died on the tenth day after debridement, intensive care, and broad-spectrum antibiotics. The cases are the first description of breast NSTI after mammary seroma aspiration and the first report of this condition caused by P. aeruginosa. Conclusion: Necrotizing soft tissue infection is rare in breast tissue. It frequently is of Type II, occurring mainly after procedures in patients with breast cancer. The surgeon's participation in controlling the focus of the infection is of fundamental importance, and just as important are broad-spectrum antibiotic therapy and support measures, such as maintenance of volume, correction of electrolytic disorders, and treatment of sepsis and septic shock. Once the infection has been brought under control, skin grafting or soft tissue flaps can be considered. The mortality rate in breast NSTI is 18.7%, all deaths being in patients with the fulminant Type II form. Surgical oncologists need to be alert to the possibility of this rare condition. © 2012, Mary Ann Liebert, Inc.

¿Por qué hay tanta inseguridad económica en América Latina?

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¿Hay espacio para el desarrollo local en la globalización?

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Prestaciones sociales en Uruguay: ¿por qué hay beneficiarios que no las solicitan?

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Modified radical mastectomy: A pilot clinical trial comparing the use of conventional electric scalpel and harmonic scalpel

Background: The aim of this study was to compare the rates of local postoperative complications among women undergoing modified radical mastectomy with an electric scalpel (ES) or a harmonic scalpel (HS). It is thought that HS use has less postoperative complications, mainly seroma formation. Methods: This study was a prospective non-randomised clinical trial (NCT01391988) among consecutive patients, performed in parallel. Patients underwent modified radical mastectomy using an HS or ES. We analysed the following operative variables: time, blood loss and seroma volume drainage. Postoperative complications, including seroma, flap necrosis, haematoma and infection were evaluated on the 7th and 14th days. Results: Forty-six patients underwent a MRM with ES and 49 with HS; no differences were observed between the groups. The rate of local complications was 29% in the HS group and 52% in the ES group (p=0.024). The rates of seroma (16.3% versus 28.3%; p=0.161), necrosis (4.1% vs. 21.7%; p=0.013; OR=0.15), haematoma (2.0% vs. 8.7%; p=0.195) and infection (2.0% vs. 6.5%; p=0.351) were lower in the HS group. Adding the findings of all comparative studies using HSs in MRM to the seroma rates in the current study, the seroma rate, expressed as a categorical variable, did not decrease with HS. Seroma was present in 60/219 cases using an HS and in 69/239 cases utilising an ES (p=0.72). Based on a multivariate analysis, HS decreased the risk of skin necrosis (p=0.015). Conclusions: HSs do not decrease the seroma rate. However, this method may be useful in skin sparing mastectomy because it decreases skin flap necrosis. © 2013 Surgical Associates Ltd.

Nuevos problemas y oportunidades para el desarrollo industrial de América Latina

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A palavra arbitrária: estudo e tradução de Fenêtres dormantes et porte sur le toit, de René Char

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O Correio Braziliense e seu projeto de civilização (1808-1822)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Rios e terras: história ambiental de Goiás (1822-1850)

Pós-graduação em História - FCLAS

Os socorros públicos no Império do Brasil 1822 a 1834

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A instrução como escultora da sociedade: a construção do estado nacional brasileiro em seu primeiro momento de autonomia política 1822-1831

Pós-graduação em História - FCLAS

Dívida pública brasileira (1822-2004): sua história e os efeitos sobre o crescimento econômico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da amonização de fenos de resíduo de pós-colheita de sementes de Brachiaria brizantha, cv. Marandu

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O poder municipal e as práticas mercantilistas no mundo colonial: um estudo sobre a Câmara Municipal de São Paulo – 1780-1822

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A coluna “Reflexões” de Hipólito da Costa no Correio Brasiliense (1808-1822): uma voz pela liberdade de imprensa, união do Brasil com Portugal e contra governos despóticos

Pós-graduação em Letras - FCLAS