O longo caminho: guerreiro ramos e a sociologia da administração antes de a nova ci��ncia das organiza����es

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Alicerces da administração na constru����o do ensino e da pesquisa em Unidades de Informa����o

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Forma����o, fun����o e formas de provimento do cargo do gestor escolar: as diretrizes da pol��tica educacional e o desenvolvimento te��rico da administração escolar

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

As publica����es da ANPAE e a trajet��ria do conhecimento em Administração da educa����o no Brasil

This paper reports on the trajectory of knowledge in educational administration, as published by the Brazilian National Association of Educational Policy and Administration (ANPAE). It reviews four early booklets on school administration ��� Cadernos de Administração Escolar ��� published between 1961 and 1968, and selected issues of ANPAE��s journal ��� Revista Brasileira de Pol��tica e Administração da Educa����o ��� published between 1983 and 2000, under different categories, and analyses those classified under the concepts of administration and management. The author refers to conceptual limitations, but concedes that the publications present relevant contributions on the theoretical development of educational administration in Brazil.

Efeitos da intera����o e solu����es utilizadas na preven����o da forma����o do precipitado originado pela intera����o do hipoclorito de s��dio e do diglunato de clorexidina e a repercurs��o sobre a resist��ncia de uni��o de cimento obturador na dentina do canal radicular

P��s-gradua����o em Odontologia - FOAR

Benef��cios e dificuldades na utiliza����o dos jogos de empresas: survey em cursos de gradua����o em administração na regi��o noroeste do estado de S��o Paulo

P��s-gradua����o em Engenharia de Produ����o - FEB

Semi��tica e administração: a comunica����o e o rela����es-p��blicas como forma de gest��o

This work has as objective understand the role of chief public relations professional in the design of strategies for an organization considering the theories of semiotics, particularly the concepts of Firstness, secondness and Thirdness defended and presented by Charles Sanders Peirce, and business administration. We will give attention to the process that the public relations of an organization sets the detection of a problem / opportunity until the moment that takes science for all individuals and is resolved / utilized in an organization. Then to better illustrate the concepts presented, it has been a case study of the performance of a public relations professional in an organization, and its importance in her career

Desenvolvimento de nanopart��culas de quitosana para adminstra����o nasal de zidovudina

Zidovudine (AZT) is the drug most commonly used in AIDS treatment, isolated or in combination with other antiretroviral agents, but it has certain limitations due to its therapeutic dose-dependent haematological toxicity. In addition, it has low oral bioavailability, since it undergoes pre-systemic metabolism. The nasal route has been used as an alternative route for drug administration, because it can promote its direct absorption to blood circulation, avoiding hepatic metabolism. However, this route presents as a factor limiting the mucociliary clearance mechanisms that remove quickly the formulation of the nasal cavity. To prolong the residence time of formulations, in this direction, has been proposed the development of mucoadhesive systems. Among the various existing systems, the use of chitosan (QS), as mucoadhesive polymer, has been widely exploited in the preparation of nanoparticles (NPs). The objective of this study was to develop and characterize QS���s NPs for intranasal administration of AZT. For both NPs have been developed by ionic crosslinking of QS with sodium tripolyphosphate (TPP). These NPs were characterized by studies of particle size distribution, zeta potential, morphology, mucoadhesion tests, assessing the ability of encapsulation of the drug and permeation profile of AZT. The evaluation of AZT in the NPs was determined by UV-Vis spectroscopy. Mucoadhesion measures were made using a texture analyzer, using a mucin disk and porcine mucous membrane , and permeation assay were conducted using porcine nasal mucous membrane adapted to the Franz cell. These results suggest that the systems in hand have great potential for nasal AZT administration

Estudo do Comportamento da Viscosidade de Sistemas de Carboximetilcelulose de S��dio e Diferentes Componentes nos produtos para industria aliment��cia

Currently, the food market is a great competition. It is no longer unanimously in the CMC powder drinks, as in the past, xanthan gum, always seeking to develop more economic alternatives, such as guar gum. It is clear, therefore, it is of vital importance to understand thoroughly the operation of a particular product in different process conditions and with different materials so that we can develop and adapt both new processes and products to new market reality

Avalia����o da influ��ncia do estresse em modelo experimental de colite por administração de ��cido Trinitrobenzenosulf��nico (TNBS) em concentra����o subinflamat��ria

Inflammatory bowel disease (IBD) is a chronic and relapsing disease caused by exaggerated response of the immune system. It represents a significant health problem by limiting the quality of life and being the main risk factor for colorectal cancer. Despite of its importance, the high worldwide incidence and being the object of research for several decades, the etiology remains unknown. Studies indicates an interaction between genetic and environmental factors which together with the intestinal microbiota, leads to an uncontrolled immune response. One of the aggravating environmental factors often discussed is stress, as the daily life of the population in general is increasingly rushed. In order to demonstrate the influence of stress on IBD, this study aimed to standardize an experimental model of colitis induced by instillation of a trinitrobenzene sulfonic acid (TNBS) noninflammatory concentration plus exposure to stress that intensify the inflammation. Therefore, an experiment was done to determine what would be the noninflammatory concentration. In this step, four different concentrations of TNBS (1, 6, 12.5 or 40mg/ml) were tested and the lowest concentration capable of inducing a noninflammatory response in the gut was defined as 1 mg/ml. Then, a second experiment was performed which induced colitis and exposed the animals to restraint stress. The results, however, showed that this stimulus was not enough to exacerbate the damage caused by the 1 mg/ml concentration of TNBS in the colon. With some changes in the protocol, the third experiment associated cold and restraint, as well as changes on the day of euthanasia, which occurred immediately after the stress session. The results of myeloperoxidase activity measurement were unexpected due to the noninflammatory concentration of TNBS caused an intestinal inflammation similar to the concentration of 40 mg/ml. However, the results of glutathione quantification and the corticosterone ...

Avalia����o do potencial de sistemas nanoestruturados estabilizados com poli��ter funcional siloxano para administração t��pica de metotrexato

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Avalia����o do estado emocional associado �� catalepsia causada pela administração intraperitoneal de haloperidol

Haloperidol is a dopamine receptor antagonist used to treat schizophrenia. When systemically administered in rodents, haloperidol induces catalepsy, a state of immobility very similar to that seen in Parkinson's disease. It is known that many of Parkinson's disease symptoms are dependent on the emotional state since patients are still able to respond to external triggers such as loud noise or visual signaling. Recent data highlighted the importance of glutamatergic neurotransmission in the inferior colliculus (IC) on the cataleptic state induced by haloperidol in rats. Given the importance of IC in the brain aversion system and its connections to motor pathways, and based on the clinical reports of the emotional influence on the motor aspect of Parkinson's disease, the objective of the present study was to evaluate the emotional aspect related to catalepsy induced by intraperitoneal administration of haloperidol. To this end, we analysed ultrasonic vocalizations (UVs) of 22 kHz (indicative of aversion) in rats during the tests of catalepsy, open field and contextual conditioned fear. Systemic administration of haloperidol affected the motor activity, inducing catalepsy and decreasing exploratory activity in the open field. There were no UVs of 22 kHz resulting from treatment with haloperidol in catalepsy or open field tests. In the contextual conditioned fear test, haloperidol increased freezing when administered before the test, but decreased freezing on test day when administered before training. In this same test, haloperidol decreased the UVs on the day it was administered (training or test). The catalepsy induced by systemic administration of haloperidol seems to have also affected the motor aspect of UVs. In this way, it was not possible to clarify the existence of an aversive emotional state associated haloperidol induced catalepsy

Dispers��es s��lidas mucoadesivas para administração oral de zidovudina

A S��ndrome da Imunodefici��ncia Adquirida (AIDS) �� uma doen��a causada pelo v��rus da imunodefici��ncia humana (HIV) e acomete milh��es de indiv��duos pelo mundo todo. Para seu tratamento, utilizam-se antirretrovirais em associa����o ou isoladamente, e um dos mais utilizados �� a zidovudina, 3���-azido-3���-desoxitimidina (AZT). Por��m, sua baixa biodisponibilidade causada pela elevada taxa de metaboliza����o hep��tica e baixa capacidade de permea����o atrav��s das membranas biol��gicas, resulta na necessidade de administração de elevadas doses do f��rmaco, v��rias vezes ao dia, o que acaba gerando n��veis plasm��ticos t��xicos e, consequentemente, efeitos colaterais graves e desconforto ao paciente. Sendo assim existe a necessidade de uma otimiza����o das formula����es orais contendo AZT. Os sistemas de libera����o de f��rmacos com propriedades mucoadesivas podem ser uma alternativa para melhorar as propriedades biofarmac��uticas, pois permitem o contato ��ntimo do f��rmaco com a mucosa intestinal e por um tempo prolongado, o que pode melhorar a biodisponibilidade de determinados f��rmacos, como o AZT. As dispers��es s��lidas (DS) s��o um tipo de sistema de libera����o de f��rmaco que visam melhorar a biodisponibilidade de f��rmacos com baixa biodisponibilidade. Para desenvolvimento destes sistemas, v��rios materiais polim��ricos podem ser utilizados, dentre eles o ftalato de hidroxipropil metilcelulose (HPMCP), com propriedade gastrorresistentes e mucoadesiva e o glicolato s��dico de amido (GSA), que �� um pol��mero intumesc��vel e mucoadesivo. No desenvolvimento do trabalho as dispers��es foram preparadas a partir da t��cnica de evapora����o do solvente, contendo AZT, GSA e HPMCP nas propor����es 1:5:7,5, 1:5:10 e 1:5:15, respectivamente, sendo obtidas com ��xito a partir da t��cnica escolhida. A an��lise granulom��trica e as fotomicrografias das amostras demonstraram uma redu����o no tamanho das part��culas. A an��lise da mucoades��o ...

Avalia����o do potencial de carreadores lip��dicos nanoestruturados para a administração cut��nea de trans-resveratrol

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

A����o antimicrobiana da clorexidina gel e l��quida e do hipoclorito de s��dio

The purpose of this study was to evaluate in vitro antimicrobial activity of chlorhexidine gel and liquid 2%, and 2% sodium hypochlorite on Candida albicans, Enterococcus faecalis, Escherichia coli in root canals. For this, we used 40 human single-rooted teeth were divided into 4 groups (n = 10) according to assist the chemical used: 1) 2% chlorhexidine liquid, 2) 2% chlorhexidine gel, 3) sodium hypochlorite 2%, and 4) physiological saline (control). Content were collected immediately after root canal instrumentation and after 7 days of biomechanical. For the samples was conducted to evaluate the antimicrobial activity and the results were subjected to statistical analysis of Kruskal-Wallis and Dunn's test with a significance of 5%. It was found that chlorhexidine gel and liquid as well as sodium hypochlorite were effective against the microorganisms tested