Natural chromenes and chromene derivatives as potential anti-trypanosomal agents

The aim of the study was to investigate the anti-trypanocidal activities of natural chromene and chromene derivatives. Five chromenes were isolated from Piper gaudichaudianum and P. aduncum, and a further seven derivatives were prepared using standard reduction, methylation and acetylation procedures. These compounds were assayed in vitro against epimastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease. The results showed that the most of the compounds, especially those possessing electron-donating groups as substituents on the aromatic ring, showed potent trypanocidal activity. The most active compound, [(2S)-methyl-2-methyl-8-(3″-methylbut-2″-enyl)-2- (4′-methylpent-3′-enyl)-2H-chromene-6-carboxylate], was almost four times more potent than benznidazole (the positive control) and showed an IC 50 of 2.82 μM. The results reveal that chromenes exhibit significant anti-trypanocidal activities and indicate that this class of natural product should be considered further in the development of new and more potent drugs for use in the treatment of Chagas disease. © 2008 Pharmaceutical Society of Japan.

Foreign Investment in Latin America and the Caribbean 2000

Includes bibliography

Glass-ceramic material from the SiO 2-Al 2O 3-CaO system using sugar-cane bagasse ash (SCBA)

Brazil is the world's largest producer of alcohol and sugar from sugarcane. Currently, sugarcane bagasse is burned in boilers to produce steam and electrical energy, producing a huge volume of ash. The major component of the ash is SiO 2, and among the minor components there are some mineralizing agents or fluxing. Published works have shown the potential of transforming silicate-based residues into glass-ceramic products of great utility. This work reports the research results of SCBA use to produce glass-ceramics with wollastonite, rankinite and gehlenite as the major phases. These silicates have important applications as building industry materials, principally wollastonite, due to their special properties: high resistance to weathering, zero water absorption, and hardness among others. The glasses (frits) were prepared mixing ash, calcium carbonate and sodium or potassium carbonates as flux agents, in different concentrations. X-ray fluorescence was used to determine the chemical composition of the glasses and their crystallization was assessed by using thermal analysis (DTA/DSC/TGA) and X-ray diffraction. The crystallization kinetics was evaluated using the Kissinger method, giving activation energies ranging from 200 to 600 kJ/mol. © 2011 Ceramic Society of Japan.

The motive ideas behind three industrialization processes

Includes bibliography

A crise econômica no Japão após os anos 90

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Final report: national and state policies for micro, small and medium enterprises in Brazil

Includes bibliography

Final report: innovative processes in SMEs: some considerations about the Argentine case

Includes bibliography

O patinho feio e O rouxinol e o imperador da China, de Hans Christian Andersen: a literatura infantil em uma 4ª série do ensino fundamental em Presidente Prudente

Pós-graduação em Educação - FCT

A assistência oficial para o desenvolvimento na política externa japonesa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Capital Flows to Latin America and the Caribbean: Recent Developments

For six years, the global economy has been driven by the U.S. Federal Reserve’s policies of easy money. Liquidity has flowed from developed to developing economies, financing infrastructure and corporate investment and allowing consumers to indulge in credit-fuelled retail spending. Thus the effective ending of the Fed’s third round of asset purchases (QE3) at the end of October represents both a watershed and the beginning of a new stage in the world economy. The end of asset-purchases comes at a challenging time for emerging markets, with China’s economy slowing, the Euro zone struggling to avoid a recession and the Japanese economy already in recession. The unwinding of the U.S. monetary stimulus, while the European Central Bank and the Bank of Japan step up their monetary stimulus, has underpinned an appreciation by the U.S. dollar, in which most commodities are priced. An appreciated dollar makes dollar-denominated commodities more expensive to buyers, thereby creating pressure for sellers to lower their prices. Latin American markets ended the third quarter of 2014 under pressure from a stronger U.S. dollar. In this changing external context, there are many signs that a slowdown in Latin American and Caribbean (LAC) financial markets, particularly debt markets, which have been breaking issuance records for the past six years, may slowdown from now on. Commodity prices – including those of oil, base metals and some goods – are in a prolonged slump. The Bloomberg commodity price index, a benchmark of commodity investments, has fallen to a five-year low as China’s economy slows down, and with it the demand for commodities. Investment into the LAC region has decelerated, in large part because of a deceleration of mining investments. Latin American currencies have suffered depreciations, as current account deficits have widening for a number of countries. And LAC companies, having issued record amounts of foreign currency bonds may now struggle to service their debt. In October, credit-rating agency Moody’s downgraded the bonds of Brazil’s Petrobras to tow notches above speculative grade because of the impact of falling oil prices and the weaker real on its debt. Growth prospects look brighter in 2015 relative to 2014, but a strengthening U.S. dollar, uneven global growth and weakness in commodity prices are skewing the risk toward the downside for the 2015 forecasts across the region. The Institute of International Finance expects the strengthening of the dollar to have a divergent impact across the region, however, depending on trade and financial linkages. The Institute of International Finance, Capital Flows to Emerging Markets, October 2, 2014. A stronger dollar lifts U.S. purchasing power, supporting exports, growth and capital inflows in countries with close trade links to the U.S. economy. However, rising dollar financing costs will increase pressure on countries with weak external positions. Given the effects of falling oil prices and a stronger dollar, some companies in the region, having issued record amounts of foreign currency bonds, may now struggle to service their debts. Prospects of Fed rate hikes resulting in tighter global liquidity amid the rapid rise in the corporate external bond stock has indeed raised concerns over some companies. However, there is still a shortage of bonds at a global level and the region still enjoys good economic policy management for the most part, so LAC debt markets may continue to enjoy momentum despite occasional bursts of high volatility – even if not at the record levels of recent years.

Capital Flows to Latin America and the Caribbean: 2014 Overview

Divergence in macro trends and in monetary policy in advanced economies was a dominant driver of rates and currencies in emerging markets in 2014. Diverging macroeconomic developments were reflected in different monetary policy actions in 2014, with the European Central Bank (ECB) and the Bank of Japan (BOJ) moving in the opposite direction of the U.S. Federal Reserve. The unwinding of the U.S. monetary stimulus, while the ECB and the BOJ step up their monetary stimulus, has underpinned an appreciation by the U.S. dollar, in which most commodities are priced. Latin American markets, which started the year under pressure from fears of the U.S. Federal Reserve tapering off its quantitative easing program and concerns over stability, ended 2014 under pressure from a stronger U.S. dollar. However, there are many signs that a slowdown in LAC financial markets – particularly debt markets, which have been breaking records in debt issuance for the past six years – is under way. The region’s growth prospects look somewhat brighter in 2015 relative to 2014, but a strengthening U.S. dollar, uneven global growth and weakness in commodity prices are skewing the risk toward the downside for the 2015 forecasts across the region.

Imigração e ocupação na fronteira do tapajós: os japoneses em Monte Alegre – 1926-1962

Desde 1925, quando assumiu o comando do governo paraense, Dionísio Bentes procurou incentivar a colonização do “sertão” paraense com o objetivo de dinamizar a produção agrícola. Para efetivar o projeto, o governo esforçou-se para atrair o interesse do Japão, oferecendo gratuitamente terras para o assentamento dos imigrantes japoneses. Como resultado do acordo diplomático firmado entre partes interessadas, a partir do final de 1929, teve início o processo migratório que se estendeu até 1962, com interrupção entre 1937 e 1952. Durante quase três décadas, cerca de 1.600 famílias desembarcaram no porto paraense. A grande maioria fixou-se no Estado do Pará, formando uma significativa comunidade de imigrantes e seus descendentes. Assim, esta dissertação trata do processo que conduziu essa migração, à construção do modo de vida na Amazônia e à elaboração da identidade no novo ambiente. O enfoque principal é a colonização da cidade de Monte Alegre, no Baixo-Amazonas paraense, muito embora essa análise faça referência a outras localidades do Pará e Amazonas e também envolve um esforço para discutir tanto o processo da colonização quanto do exercício da construção da memória por parte dos imigrantes.

Epidemiologia molecular do Vírus linfotrópico de células T humanas - HTLV 1/2 no Estado do Amapá-Brasil

A distribuição geográfica da infecção pelo Vírus Linfotrópico de Células T HTLV 1/2 humanas 1 e 2 é ampla, porém existem áreas de maior endemicidade e também particularidades de acordo com o tipo de HTLV. O HTLV-1 apresenta maior soroprevalência no sudoeste do Japão, no Caribe, na América Central, nas diferentes regiões da América do Sul e nas porções centrais e ocidentais da África e Melanésia. Enquanto o HTLV-2 parece acometer grupos populacionais distintos, como as populações nativas de indígenas das Américas do Norte, Central e Sul, pigmeus da África Central, mongóis na Ásia e também usuários de drogas injetáveis. O trabalho realizado teve como objetivo descrever a epidemiologia molecular do HTLV em três populações distintas do estado do Amapá, que foram: pacientes HIV/AIDS infectado, população afro-descendente e finalmente indivíduos atendidos no Laboratório Central de Saúde Pública do Amapá (LACEN-AP), encaminhados para diagnóstico de HTLV. As amostras foram avaliadas para a presença do vírus por métodos sorológicos (ELISA e Western blot) e moleculares (amplificação gênica e caracterização de segmentos das regiões pX e env pela análise de polimorfismo de fragmentos de restrição por ação de endonuclease. Os resultados obtidos nas diferentes populações foram na população de indivíduos infectados pelo HIV/AIDS, todas as amostras foram negativas, na população afro-descendente, apenas uma amostra apresentou positividade na sorologia pelo método de ELISA, porém foi negativa no Western blot e quando submetida ao método molecular, não houve amplificação. No entanto, entre os indivíduos encaminhados para diagnóstico de HTLV, 06 (seis) amostras foram positivas, e dessas, 05 (cinco) foram confirmadas por Western blot e pelo método molecular. O resultado molecular demonstrou a presença de HTLV-1.

Crise financeira: o caso japonês

This paper aims to analyze the experience of Japan after the collapse of speculative bubbles in assets and the banking crisis in the 1990s. An analysis about the effectiveness of fiscal and monetary policy is conducted and the measures taken with respect to the banking sector are also discussed in this paper. The Japanese financial crisis experience suggests that the nature, speed and order in which the government implements measures determine, in large part, the magnitude and cost of the crisis. Therefore, in hindsight, it can be said that the following tasks were necessary: 1) recapitalize the banking sector; 2) restore credit; and 3) reinvigorate the economic activity through appropriate fiscal measures.

O trágico da leveza

This experimental project was in its effort to academic research to present a photographic essay as a product that represents the interpretation for the modality of social knowledge of journalism in creating an aesthetic directive in vogue for the expertise of fashion. For assigning meaning to photograph fashion templates proposed, a thematic representation of the object placed in a case study was lengthier and depth evidences of the catastrophic occurrence in the geographical context of Japan in March 2011