Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.

The association between increased DNA-methyltransferase (DNA-MTase) activity and tumor development suggest a fundamental role for this enzyme in the initiation and progression of cancer. A true functional role for DNA-MTase in the neoplastic process would be further substantiated if the target cells affected by the initiating carcinogen exhibit changes in enzyme activity. This hypothesis was addressed by examining DNA-MTase activity in alveolar type II (target) and Clara (nontarget) cells from A/J and C3H mice that exhibit high and low susceptibility, respectively, for lung tumor formation. Increased DNA-MTase activity was found only in the target alveolar type II cells of the susceptible A/J mouse and caused a marked increase in overall DNA methylation in these cells. Both DNA-MTase and DNA methylation changes were detected 7 days after carcinogen exposure and, thus, were early events in neoplastic evolution. Increased gene expression was also detected by RNA in situ hybridization in hypertrophic alveolar type II cells of carcinogen-treated A/J mice, indicating that elevated levels of expression may be a biomarker for premalignancy. Enzyme activity increased incrementally during lung cancer progression and coincided with increased expression of the DNA-MTase activity are strongly associated with neoplastic development and constitute a key step in carcinogenesis. The detection of premalignant lung disease through increased DNA-MTase expression and the possibility of blocking the deleterious effects of this change with specific inhibitors will offer new intervention strategies for lung cancer.

Assessment and Promotion of Partner Support: A Prevention-Focused Intervention for Perinatal Depression in Primary Care

Perinatal depression significantly impacts the mother, her partner, the unborn fetus, and the infant/child after delivery. A review of the literature supports the need for preventive intervention methods as research has shown that even with successful treatment, disruptions in attachment, temperament, and cognitive development often remain. Primary care settings are ideal targets for prevention given that they can reach a number of people at low-cost without the stigma associated with seeking help in a mental health facility. This paper purposes a preventive intervention method for perinatal depression that can be implemented in primary care settings in both Western and non-Western countries. The intervention targets two of the primary risk factors for perinatal depression; partner support and relationship quality. The intervention is structured around key target periods in gestational development and during the early weeks after delivery. Suggestions for each target visit are based on prior research that has demonstrated how psychoeducation about the transition to parenthood, as well as increased communication, can positively affect partner support and relationship quality. The ultimate goal of the intervention is not only to prevent perinatal depression but also to improve the mental health and wellbeing of the entire family system.

Developing a Citizen Volunteer Lake Monitoring Program for the Flathead Basin in Northwestern Montana for the early Detection and Prevention of the Introduction of Zebra Mussels and other Aquatic Invasive Species (AIS)

Preventing the introduction of aquatic invasive species (AIS) like zebra and quagga mussels in the U.S. is a high priority. This Capstone demonstrates zebra and quagga mussels are of concern as aquatic invasive species and a volunteer monitoring and intervention program is an effective means for early detection of AIS. This Capstone developed an AIS citizen volunteer lake monitoring program consistent with other programs concerned about AIS prevention and early detection. This Capstone concludes implementing such a voluntary program will help reduce the spread of zebra and quagga mussels and will provide early detection information to appropriate agencies empowered with response actions if species are found.

Estimate to make medical rooms, 26 June 1809

Includes estimates to alter Holden Chapel to accommodate medical classes. Alterations in the $131.50 estimate include building circular seats and installing additional shelves.

A list of books exhibited December 30, 1907--January 4, 1908, including incunabula and other early printed books in the Senn collection.

Mode of access: Internet.

Marketing resource guide for recruitment and retention of providers in the early and periodic screening, diagnosis, and treatment program (EPSDT).

"August 1982"--P. [4] of cover.

A biographical sketch, read pursuant to appointment before the Philadelphia Medical Society, at a stated meeting, on Saturday, 16th February 1810 [i. e. 1816] of their late president, Professor [B. S.] Barton ...

Note concerning portraits of Barton: p. 34.

An eulogy on the character of John Warren, M.D. : delivered at the request of the counsellors of the Massachusetts Medical Society /

Half-title: Eulogy on John Warren, M.D.

Practical observations on insanity : to which are subjoined remarks on medical jurisprudence as connected with diseased intellect /

Includes bibliographical references.

A catalogue of the medical library, belonging to the Pennsylvania Hospital; exhibiting the names of authors and editors, in alphabetical order, and an arrangement of them under distinct heads. Also, a list of articles contained in the anatomical museum; and the rules of the museum, and of the library.

Additions to "Rules" in manuscript on verso of title page.

An eulogium upon Benjamin Rush, M.D. : professor of the institutes and practice of medicine and of clinical practice in the University of Pennsylvania : who departed this life April 19, 1813, in the sixty-ninth year of his age : written at the request of the Medical Society of South Carolina, and delivered before them and others, in the Circular Church of Charleston, on the 10th of June, 1813, and pub. at their request /

Microfilm. Ann Arbor, Mich. : Xerox University Microfilms -- 1 reel ; 35 mm.

Medical sketches of the campaigns of 1812, 13, 14. To which are added, surgical cases; observations on military hospitals; and flying hospitals attached to a moving army. Also, an appendix, comprising a dissertation on dysentery ... and observations on the winter epidemic of 1815-16, denominated peripneumonia notha; as it appeared at Sharon and Rochester, state of Massachusetts.

Austin, R.B. Early Amer. medical imprints,