Jerome Bruner y la organización de las habilidades motrices en la infancia

Bruner (1973a) partió de la idea de que el estudio de las habilidades infantiles no debía ser considerado un capítulo más en la psicología evolutiva sino una cuestión clave para comprender la evolución del ser humano como especie. Entre los asuntos relevantes a estudiar estaban: La intención, las retroalimentaciones y los esquemas de acción que mediaban entre ambas. Es a la intención a la que dedicará parte de su investigación y ha sido asunto tratado por estudiosos posteriores del comportamiento motor (Davids, 2001).

Georges Stephenson [Material gráfico] Ingenieur du chemin de Liverpool, Manchester, père de Robert

Inscripción en al ángulo inferior derecho: "1er. Volume"

James Turrell y Robert Irwin. Coincidencias, Manhattan, 2013

Durante el verano de 2013 Manhattan albergó las muestras de dos artistas que trabajan con la luz y el espacio: una amplia exposición retrospectiva de James Turrell en el Museo Guggenheim y una instalación de Robert Irwin para el Museo Withney de Arte Americano. Ambos han hecho de la percepción el elemento fundamental de sus obras en una investigación que comenzó en los años sesenta y que han continuado desarrollando a lo largo de los últimos cuarenta y cinco años. Los dos compartieron en sus comienzos una línea de investigación conjunta, sis investigaciones sobre las sensaciones en el espacio y su estudio empírico fueron cruciales para el desarrollo de sus obras que hacen de la experiencia espacial un mecanismo de trascendencia. Sus trabajos son de gran interés para la arquitectura poarque los dos hacen de la percepción en el espacio el argumento fundamental de su investigación artística.

Development of pilus organelle subassemblies in vitro depends on chaperone uncapping of a beta zipper

The major subassemblies of virulence-associated P pili, the pilus rod (comprised of PapA) and tip fibrillum (comprised of PapE), were reconstituted from purified chaperone-subunit complexes in vitro. Subunits are held in assembly-competent conformations in chaperone-subunit complexes prior to their assembly into mature pili. The PapD chaperone binds, in part, to a conserved motif present at the C terminus of the subunits via a beta zippering interaction. Amino acid residues in this conserved motif were also found to be essential for subunit–subunit interactions necessary for the formation of pili, thus revealing a molecular mechanism whereby the PapD chaperone may prevent premature subunit–subunit interactions in the periplasm. Uncapping of the chaperone-protected C terminus of PapA and PapE was mimicked in vitro by freeze–thaw techniques and resulted in the formation of pilus rods and tip fibrillae, respectively. A mutation in the leading edge of the beta zipper of PapA produces pilus rods with an altered helical symmetry and azimuthal disorder. This change in the number of subunits per turn of the helix most likely reflects involvement of the leading edge of the beta zipper in forming a right-handed helical cylinder. Organelle development is a fundamental process in all living cells, and these studies shed new light on how immunoglobulin-like chaperones govern the formation of virulence-associated organelles in pathogenic bacteria.

Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens including DNA, ribosomal P, Ro (SS-A), La (SS-B), and the spliceosome. Etiology is suspected to involve genetic and environmental factors. Evidence of genetic involvement includes: associations with HLA-DR3, HLA-DR2, Fcγ receptors (FcγR) IIA and IIIA, and hereditary complement component deficiencies, as well as familial aggregation, monozygotic twin concordance >20%, λs > 10, purported linkage at 1q41–42, and inbred mouse strains that consistently develop lupus. We have completed a genome scan in 94 extended multiplex pedigrees by using model-based linkage analysis. Potential [log10 of the odds for linkage (lod) > 2.0] SLE loci have been identified at chromosomes 1q41, 1q23, and 11q14–23 in African-Americans; 14q11, 4p15, 11q25, 2q32, 19q13, 6q26–27, and 12p12–11 in European-Americans; and 1q23, 13q32, 20q13, and 1q31 in all pedigrees combined. An effect for the FcγRIIA candidate polymorphism) at 1q23 (lod = 3.37 in African-Americans) is syntenic with linkage in a murine model of lupus. Sib-pair and multipoint nonparametric analyses also support linkage (P < 0.05) at nine loci detected by using two-point lod score analysis (lod > 2.0). Our results are consistent with the presumed complexity of genetic susceptibility to SLE and illustrate racial origin is likely to influence the specific nature of these genetic effects.

A distinção entre regras e princípios segundo Robert Alexy : esboço e críticas

Inclui notas explicativas, bibliográficas e bibliografia