The role of B-mode ultrasonography in the musculoskeletal anatomical evaluation of the cervical region of the dog spine

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Um estudo introdutório da literatura de João Carlos Marinho

Pós-graduação em Letras - FCLAS

Os tons de Zé: transformações paradigmáticas na obra de Tom Zé (1967-1976)

Pós-graduação em Música - IA

Estudo do efeito da composição e da nanoestrutura de nanopartículas de 'PT''NI' suportadas em carbono na eletrocatálise da reação de redução do oxigênio

Pós-graduação em Química - IQ

Dinâmica do sistema binário Plutão-Caronte

Pós-graduação em Física - FEG

Anestesia espinhal no lagarto Iguana iguana (Linnaeus, 1758)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Entre improvisos e desafios: do cururu como cosmovisão de grupos caipiras do Médio Tietê, SP

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Falha no bloqueio após anestesia subaracnoidea: frequência e fatores contribuintes

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudo do comportamento de discos abrasivos, em operações do tipo Cut-off por mergulho basculante, submetidos à diversas condições de corte sem lubrificação

O corte de aços por disco abrasivo é um dos processos que apresentam as melhores características de economia, eficiência e rapidez, e ainda hoje é muito utilizado no meio industrial se comparado a outros processos tradicionais de corte como o cisalhamento (tesourão), torneamento (sangramento), serragem com serras metálicas, serragem por atrito com lâminas circulares sem dentes e chama oxi-acetileno. Da literatura formal mais recente, nota-se que durante os últimos anos as máquinas para a realização dos cortes foram inovadas. Entretanto, esta atenção não foi dada à ferramenta de corte abrasiva. A falta de literatura técnica dificulta a escolha das condições de corte e da sua otimização no meio industrial. Este fato é agravado pela grande diversidade de discos abrasivos disponíveis no mercado, com diferentes qualidades e preço. As decisões sobre as condições de corte são baseadas em experiências pessoais, sem critério definido, e freqüentemente desprezam os aspectos de segurança inerentes ao processo. A concorrência estrangeira, através da globalização da economia, está obrigando as indústrias nacionais a atenderem os padrões internacionais de qualidade e desempenho. Uma forma das indústrias nacionais tornarem-se mais competitivas é através do conhecimento detalhado das operações de corte com discos abrasivos. Neste trabalho é apresentado um estudo sobre o comportamento de discos abrasivos, submetidos a diversas condições de corte. Os resultados são discutidos em função da análise da velocidade de corte, velocidade de mergulho do disco abrasivo na peça, força tangencial de corte média, tempo de corte e relação G.

Desenvolvimento de nanopartículas de quitosana para adminstração nasal de zidovudina

Zidovudine (AZT) is the drug most commonly used in AIDS treatment, isolated or in combination with other antiretroviral agents, but it has certain limitations due to its therapeutic dose-dependent haematological toxicity. In addition, it has low oral bioavailability, since it undergoes pre-systemic metabolism. The nasal route has been used as an alternative route for drug administration, because it can promote its direct absorption to blood circulation, avoiding hepatic metabolism. However, this route presents as a factor limiting the mucociliary clearance mechanisms that remove quickly the formulation of the nasal cavity. To prolong the residence time of formulations, in this direction, has been proposed the development of mucoadhesive systems. Among the various existing systems, the use of chitosan (QS), as mucoadhesive polymer, has been widely exploited in the preparation of nanoparticles (NPs). The objective of this study was to develop and characterize QS’s NPs for intranasal administration of AZT. For both NPs have been developed by ionic crosslinking of QS with sodium tripolyphosphate (TPP). These NPs were characterized by studies of particle size distribution, zeta potential, morphology, mucoadhesion tests, assessing the ability of encapsulation of the drug and permeation profile of AZT. The evaluation of AZT in the NPs was determined by UV-Vis spectroscopy. Mucoadhesion measures were made using a texture analyzer, using a mucin disk and porcine mucous membrane , and permeation assay were conducted using porcine nasal mucous membrane adapted to the Franz cell. These results suggest that the systems in hand have great potential for nasal AZT administration

Avaliação de métodos de triagem e de detecção fenotípica de ß-lactamase de espectro ampliado (ESBL)

The catalytic function of extended-spectrum β-lactamases can result in high degrees of bacterial resistance to β-lactamic antimicrobials and in the emergence of ESBL among the members of Enterobacteriaceae family, especially Klebsiella pneumoniae and Escherichia coli. This occurs due to the dissemination and emergence of new variants of these enzymes caused by the high utilization of antibiotics like broad-spectrum cephalosporins. The ESBL are β-lactamases capable of conferring bacterial resistance to the penicillins, 1st, 2nd and 3rd generation cephalosporins, and aztreonam (but not cephamycins and carbapenems) through the hydrolysis of these antibiotics. In view of this phenomenon, the exact screening and detection of the producers of ESBL are essential for the appropriate selection of the antimicrobial therapy. The purposes of this study were to evaluate the best antimicrobial for the selection of ESBL producers and to determine the best method for the detection of such microorganisms. We evaluated 200 sequential bacterial samples including the species Klebsiella pneumoniae (56.5%), Escherichia coli (34%), Proteus mirabilis (8.5%) and Klebsiella oxytoca (1%), previously characterized as ESBL producers between February and September 2008 in the Laboratory of Microbiology, Botucatu Medical School - UNESP, Botucatu, São Paulo State, Brazil. To select the ESBL-producer bacteria, we used the disks recommended by CLSI 2008, aztreonam (ATM), cefpodoxime (CPD), ceftriaxone (CRO), cefotaxime (CTX) and ceftazidime (CAZ), besides cefepime (FEP). ESBL production was confirmed by three methods: double disk screening, ESBL Etest®, and Vitek® automated system. The disks employed in the double disk screening were: penicillin associated with β-lactamase inhibitor, amoxicillin-clavulanic acid, and two β-lactamic antibiotics, ceftazidime and cefotaxime...(Complete abstract click electronic access below)

Comparação das técnicas semi-quantitativa e quantitativa nas infecções relacionadas a cateter em neonatos e determinação da resistência à oxacilina nos Staphylococcus spp

Study the semi-quantitative and quantitative technique in the diagnosis of catheter-related infections in newborns and to determine oxacillin resistance in Staphylococcus isolated. It was analyzed 353 catheter tips from 273 newborns in the Neonatal Unit of Hospital FMB. To confirm the diagnosis of infection, were analyzed the clinical data of newborns, the presence of at least one positive blood culture and growth of ≥ 1000 CFU/mL on quantitative culture and/or ³15 UFC on semiquantitative culture, with the same microorganism isolation (species and drug sensitivity) in blood culture and no other focus of infection except the catheter. The disk diffusion technique was used to check similarity of strains and resistance to oxacillin. Of the 353 tips analyzed, 39 were included in this study as the inclusion criteria. The semiquantitative culture was positive in 26 (66.7%) catheters and quantitative culture was positive in 24 (61.5%). Of 273 patients, 19 (6.9%) had a diagnosis of catheter-related bloodstream Infection (CR-BSI). Of the 19 episodes of CR-BSI, S. epidermidis was the predominant etiological agent (84.2%). The resistance to the antibiotic methicillin was found in 14 (73.7%) strains of Staphylococcus. The semiquantitative method was more sensitive (79%) compared with the quantitative method (63%). The use of antibiotics may have influenced the sensitivity of the quantitative method as the microorganisms present in the lumen are exposed to higher concentrations of antibiotics administered via the catheter

Estudo da deformação heterogênea no ensaio do anel de atrito

The plastic deformation is widely used in the metallurgical market due to its positive factors such as low prices and high speed production. Forming process products are obtained in high quality, both surface quality and mechanical properties. Friction is an importante factor in metal forming. Friction study in metal forming can be accomplished indirectly, such as the ring test of friction. Two samples of different materials being mild steel and copper alloy were used. The results showed the influence of friction in the flow behavior of the deformation of the second phase, as evidenced by standard metallography. It is observed that in the outer regions of the ring, plastic deformation occured in the radial direction. In the central region of the disc deformation occured in the direction of compression and the inner region of the ring flux lines showed a significant deformation in the radial direction towards the center of the ring

Estudo fenotípico e genotípico da produção de biofilme por Staphylococcus aureus isolados de leite bubalino e ambiente de ordenha

Pós-graduação em Microbiologia Agropecuária - FCAV

Fatores e mecanismos que influenciam a resistência em soja a Anticarsia gemmatalis Hübner e Spodoptera frugiperda (J. E. Smith)

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV