Les revendications juives : discours prononcé au nom de la Délégation juive ; 3me Conférence des Nationalités Lausanne, 27-29 juin 1916

par Zevi Aberson

Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative.

OBJECTIVE To provide guidance on standards for reporting studies of diagnostic test accuracy for dementia disorders. METHODS An international consensus process on reporting standards in dementia and cognitive impairment (STARDdem) was established, focusing on studies presenting data from which sensitivity and specificity were reported or could be derived. A working group led the initiative through 4 rounds of consensus work, using a modified Delphi process and culminating in a face-to-face consensus meeting in October 2012. The aim of this process was to agree on how best to supplement the generic standards of the STARD statement to enhance their utility and encourage their use in dementia research. RESULTS More than 200 comments were received during the wider consultation rounds. The areas at most risk of inadequate reporting were identified and a set of dementia-specific recommendations to supplement the STARD guidance were developed, including better reporting of patient selection, the reference standard used, avoidance of circularity, and reporting of test-retest reliability. CONCLUSION STARDdem is an implementation of the STARD statement in which the original checklist is elaborated and supplemented with guidance pertinent to studies of cognitive disorders. Its adoption is expected to increase transparency, enable more effective evaluation of diagnostic tests in Alzheimer disease and dementia, contribute to greater adherence to methodologic standards, and advance the development of Alzheimer biomarkers.

Gedenkschrift zur Erinnerung an die Brüder Jesaia Strassburger s.A., Rabbiner in Ulm 1906-1915, Dr. Ferdinand Strassburger s.A., Rabbiner in Ulm 1916-1927

von A. Tänzer

Gedächtnisrede zu Ehren des verewigten Vorsitzenden der Gesellschaft zur Förderung der Wissenschaft des Judentums, des Prof. Dr. Martin Philippson, gehalten in d. Mitgliederversammlung zu Berlin am 27 Dez. 1916

von Philipp Bloch

From the Sea to Paris and back: On the interdependence of economic warfare, weather conditions and the submarine campaign 1916-1917

Starting of from Avner Offer’s comment that the First World War was not only a war of steel and gold, but also of bread and potatoes (1989: 1) and my own research on British as well as Australian preparations for economic warfare and based on sources from the entente as well as the central powers but also from the United States, Canada and Australia, may presentation will focus on the interdependence of the measures taken by entente as well as central power authorities in the second half of 1916. Already a year before both sides had become aware that this war would not only be decided on the battlefield, but that the issues of primary as well as secondary resources would be decisive. Accordingly measures that could strike the enemy in this field were discussed and put into place more and more and this at time, when weather conditions caused a reduction of harvest all over Europe, Northern America and Argentina.

Die neuesten Verlosungspläne und die arithmetisch geordneten Verlosungen von 1861 bis 1864 mit Angabe der Gewinne

von H. Marcus

Der Talmud : zwei Reden, am Hüttenfeste 5625 (am 16. und 22. Oktober 1864)

gehalten von Alfred Jellinek

Si vous n'avez rien à me dire : Und hast du mir kein Wort zu sagen? Frei nach V. Hugo von Richard Genée. Lied für eine Singstimme mit Begl. de. Pianoforte ; Op. 5 no. 1

von ... W. von Rothschild

Bekanntmachung : Aufruf zur Ablieferung von Brotscheinen für Mazzen ... vom 16. März 1916

der Vorstand der Israelitischen Gemeinde [Frankfurt a. M.]

Spatial genomic heterogeneity within localized, multifocal prostate cancer

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We initially determined the copy number aberration (CNA) profiles of 74 patients with index tumors of Gleason score 7. Of these, 5 patients were subjected to whole-genome sequencing using DNA quantities achievable in diagnostic biopsies, with detailed spatial sampling of 23 distinct tumor regions to assess intraprostatic heterogeneity in focal genomics. Multifocal tumors are highly heterogeneous for single-nucleotide variants (SNVs), CNAs and genomic rearrangements. We identified and validated a new recurrent amplification of MYCL, which is associated with TP53 deletion and unique profiles of DNA damage and transcriptional dysregulation. Moreover, we demonstrate divergent tumor evolution in multifocal cancer and, in some cases, tumors of independent clonal origin. These data represent the first systematic relation of intraprostatic genomic heterogeneity to predicted clinical outcome and inform the development of novel biomarkers that reflect individual prognosis.