Estrutura molecular e citogenética de cromossomos B em Astyanax paranae (Characiformes, Characidae)

Pós-graduação em Ciências Biológicas (Genética) - IBB

Estresse e imuno modulação por beta-glucano em Pacu (Piaractus mesopotamicus)

Pós-graduação em Aquicultura - FCAV

Análise do potencial mutagênico dos esteroides anabólicos androgênicos (EAA) e da l-carnitina mediante o teste do micronúcleo em eritrócitos policromáticos

INTRODUCTION: Anabolic androgenic steroids (AAS) are frequently used by people whose aim to increase muscle mass to obtain a better performance in sports or improve physical appearance. AAS are synthetic derivatives of testosterone, able to promote muscle fibers hypertrophy, increasing intracellular protein synthesis. L-carnitine is a food supplement used to increase energetic production by means of fat acids oxidation. Although there are several works about physiological properties of these drugs, there are few studies about their mutagenic potential. OBJECTIVES: This work evaluated the clastogenicity and genotoxicity of nandrolone decanoate, testosterone decanoate and L-carnitine, in different treatments through the micronucleus test in polychromatic erythrocytes of Wistar rats. METHODS: The animals were submitted to different concentrations and associations of AAS. The positive control received cyclophosphamide 50 mg/kg by intraperitoneal injection and negative control, one ml of saline solution by gavage. The rats were sacrificed after 36 hours of latest application, having the femurs removed and the bone marrow extracted. Material was homogenized and centrifuged. Button cell was pipetted and transferred to slides, which were stained by Giemsa. 1,000 polychromatic erythrocytes were counted per animal, noting the frequency of micronuclei. RESULTS: The Kruskal-Wallis test was performed, with a significance level of 5%, which demonstrated that nandrolone decanoate - three doses of 0,2 mg/kg and 0,6 mg/kg, eight doses of 7,5 mg/kg, L-carnitine - seven doses of 0,4 ml/250 g and 1,5 ml/250 g, testosterone decanoate - 28 doses of 0,075 mg/kg, nandrolone decanoate - eight doses of 7,5 mg/kg associated to L-carnitine and 1 mL and nandrolone decanoate - eight doses of 7,5 mg/kg associated to testosterone decanoate - eight doses of 7,5 mg/kg, showed mutagenic potential. CONCLUSION: The treatments proved to be clastogenic, not being indicated like ergogenic aid.

Fractais no ensino médio

Pós-graduação em Matemática em Rede Nacional - IBILCE

Caracterização da suinocultura em Mossoró, Rio Grande do Norte: aspectos sanitários e riscos de zoonoses

Pós-graduação em Medicina Veterinária - FCAV

Anticorpos contra Leptospira spp. e Brucella spp. em equiídeos da região Sul do Brasil abatidos em matadouro-frigorífico

Pós-graduação em Medicina Veterinária - FCAV

Isolamento e seleção de fungos filamentosos termofílicos produtores de celulases, xilanases e celobiose desidrogenase com potencial para sacarificação do bagaço de cana-de-açúcar

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Papel da matematização nas explicações de professores e alunos em disciplinas de física na formação inicial de professores

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Variação e gramaticalização no uso de preposições em contextos de verbos de movimento no português brasileiro

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Aplicação foliar de indutor de resistência em feijoeiro comum: efeito sobre desempenho da cultura, qualidade fisiológica e sanitária das sementes

Pós-graduação em Agronomia - FEIS

Prevalência e fatores de risco para brucelose suína em Mossoró-RN

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Indícios da presença de fundamentos semióticos na literatura da Ciência da Informação

The interfaces between Semiotics of Information Science must also be analysed from a broader perspective, searching for signs of interdisciplinary involvement. So, as a complement to a theoretical study on the semiotic foundations of document analysis and information mediation, we undertook the analysis of the presence of semiotic perspectives in the Information Science literature —journals papers, conference proceedings and theses. The results showed that the semiotic studies related to the information analysis and information mediation are in an incipient stage, especially in Brazil, in spite of a substantial increase in the number of publications.

Tecnologias de Informação e Comunicação em Bibliotecas Escolares: em busca de um espaço dinâmico

The Information and Communication Technologies (ICT) can be combined with the acquisition of academic knowledge and cultural development of students, as they improve their information literacy, and why not say, also digital. Weaim in this research seek references and present experiences that encourage a new concept of school library with the use of ICT in teaching and learning in individual and collective development of the student community. To complement this study we prioritized the following objectives: to insert the technology into the routine of a school library; identify the informational and technological profile of adolescents; understand the needs and technological resources they use to obtain information in daily life and also analyze the importance the effective participation of the school library in the educational context of the school, through greater interaction between the librarian, teacher and pedagogical coordination seeking a cooperative and informal ICT teaching and learning for along with the students, sharing the search for information and knowledge, in a conscious and responsible way. Chosen as theoretical foundation the cognitive studies of Jean Piaget, witch explains how the stages of assimilation and accommodation of knowledge in cooperative practices work. As a methodology was developed a participatory-action research, to learn the behavioral state of young people and adolescents, based on the model of information search for the everyday life (Everyday Life Information Seeking) – ELIS, developed by Finnish researcher Savoleinen (2006), as well as identify the informational and technological profile of adolescents from two selected approaches in the scientific literature (HUGUES-HASSEL; AGOSTO, 2007; UCL, 2008). Thus, came up the initiative to create a Confraternity of the Library in a collaborative digital environment, providing the participants discussion and learning technologies as well as digital information literacy enhancement.

Variação e gênero textual: o uso das preposições nas cartas de leitoras brasileiras e portuguesas

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Chromosome evolution in fishes: a new challenging proposal from Neotropical species

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)