Desarrollo de dos (2) líneas de nuevos productos.

68 hojas : ilustraciones.

Una (1) línea de producto de exhibición.

21 hojas : ilustraciones.

Cuatro (4) grupos artesanales dotados con sistemas de exhibición creativos y funcionales para eventos comerciales y promocionales.

72 hojas : ilustraciones.

Desarrollo de dos (2) líneas de productos mejorados.

40 hojas : ilustraciones.

Dos (2) localidades con una propuesta implementada de empaque y embalaje para sus productos.

56 hojas : ilustraciones.

C 225 INST-D 2013. 386 Talleres de carpintería con sus dotaciones de equipos y herramientas tradicionales y modernas.

30 fotografías a color

C 227 INST-D 2013. 389 Productos en madera calados y tallados en alto relieve.

8 fotografías a color.

C 232 INST-D 2013. 394 Tallas zoomorfas de productos decorativos elaborados en madera de diversos tipos.

Documento de 76 fotografías, setenta y una a color.

Informe de avance de asesoría en diseño familias vinculadas al programa de desarrollo alternativo-PDA.

40 hojas : ilustraciones, fotografías.

Muestras de productos funcionales y decorativos elaboraos en cerámica esmaltada a color.

27 hojas : ilustraciones, fotografías

Reflections on Children

In the Fall 2004, while preparing my dissertation project “Reflections on children,” I realized that whether art songs, operatic arias or scenes, the classical repertory offers a wide variety of masterpieces regarding all aspects of children’s life. My first dissertation recital is called “Journeys” and was performed on December 6th 2004 at 8:00pm in the Tawes Recital Hall. Change is the only inevitable condition in life and as such, it has been thought-provoking to many poets and composers. The narrator in Mahler’s Wayfarer Songs experiences the pain of love for the first time and emerges transformed into an adult. The narrator in Barber’s Knoxville is an adult looking back at his journey in an attempt to understand himself. The mothers in Britten’s Charm of Lullabies each make every effort to accept the changes in their own life after the birth of her baby. Finally, both Brahms’ songs are about risks and losses. “Destinies” is the title of the second dissertation recital as it attempts to capture the dark fate of Mignon and of Rückert/Mahler’s children. It was performed on April 8th 2005 in the Tawes Recital Hall. Mignon’s grief is portrayed through songs full of sadness and hopelessness in mourning of a long lost childhood. Rückert wrote 425 Kindertotenlieder in memory of his children’s deaths over a period of twenty years and Mahler orchestrated five of them. Mahler’s choices deal with light and darkness, symbolizing eternal life and hope versus despair and death, in both the literal and the literary sense. Finally, the third dissertation recital called “Blessings” was performed on May 19th 2005 in the Tawes Recital Hall. It relies on the evocation of moods and scenes created by a variety of composers and poets. Poulenc’s La Courte Paille are brief works in the style of a child’s song with unrelated and unexpected images juxtaposed, creating a sense of inner monologues. John Greer’s House of Tomorrow, Guastavino’s Cradle Songs and the rest of the composers offer wonderful pieces of immense power and expression in their directness and sensitive contour.

Highlights from the 13th St Gallen International Breast Cancer Conference 2013. Access to innovation for patients with breast cancer: how to speed it up?

The recognition that early breast cancer is a spectrum of diseases each requiring a specific systemic therapy guided the 13th St Gallen International Breast Cancer Consensus Conference [1]. The meeting assembled 3600 participants from nearly 90 countries worldwide. Educational content has been centred on the primary and multidisciplinary treatment approach of early breast cancer. The meeting culminated on the final day, with the St Gallen Breast Cancer Treatment Consensus, established by 40-50 of the world's most experienced opinion leaders in the field of breast cancer treatment. The major issue that arose during the consensus conference was the increasing gap between what is theoretically feasible in patient risk stratification, in treatment, and in daily practice management. We need to find new paths to access innovations to clinical research and daily practice. To ensure that continued innovation meets the needs of patients, the therapeutic alliance between patients and academic-led research should to be extended to include relevant pharmaceutical companies and drug regulators with a unique effort to bring innovation into clinical practice. We need to bring together major players from the world of breast cancer research to map out a coordinated strategy on an international scale, to address the disease fragmentation, to share financial resources, and to integrate scientific data. The final goal will be to improve access to an affordable, best standard of care for all patients in each country.

TWENTIETH CENTURY VARIATIONS ON BORROWED THEMES

Mergers and acquisitions are words that are usually associated with the modern business world. Such joint efforts toward improvement, however, existed long before our time, in the form of musical partnerships. It was not unusual for composers to share in each other's works, borrowing themes and recreating them to generate new meanings; in the process, new masterpieces were often created. My performance project, Twentieth Century Variations on Borrowed Themes, explores the fruits of such labor. The main objective of this project is to demonstrate how certain composers of the twentieth century have taken famous themes and used them to create variations, imbuing their own creative ideas, musical styles and pianistic challenges. This objective was accomplished by performing three recorded public recitals. These programs consisted of early to late twentieth century pieces that are based on borrowed themes, either in theme and variations form, fantasia form, paraphrase form, or transformal variation form. I have selected the pieces based on their artistic merits and technical challenges, thus allowing me to grow as a pianist and artist. In addition, I wanted to choose some pieces that are rarely performed, as I believe the public delights in hearing unfamiliar gems. The first recital consisted of the music of two legendary pianists: Variations on a Theme of Chopin by Rachmaninoff and Goldberg Variations by BachIBusoni. The second program featured Grand Fantasy on Gershwin's Porgy and Bess by Earl Wild, Sonatina No. 6 (Fantasy on Bizet 's "Carmen") by Busoni, and Rhapsody on a Theme by Paganini, op.43 by Rachmaninoff. Some unusual and seldom-performed pieces, as well as a familiar favorite, were spotlighted in the third recital. The pieces performed on this program were John Rea's Twenty-one Transformal Variations on the "Kindersznen " by Robert Schumann (Las Meninas), Muczynski's Desperate Measures (Paganini Variations), Busoni's Elegie No. 3 (Turandot 's room), and Rhapsodie Espagnole by LisztIBuson. These composers artfully breathed new life into the material borrowed from others, and in the process, the "borrowed" themes became undoubtedly and uniquely their own music.

Outer Membrane Vesicle Production in Escherichia coli Relieves Envelope Stress and is Modulated by Changes in Peptidoglycan

Bacterial outer membrane vesicles (OMVs) are spherical buds of the outer membrane (OM) containing periplasmic lumenal components. OMVs have been demonstrated to play a critical part in the transmission of virulence factors, immunologically active compounds, and bacterial survival, however vesiculation also appears to be a ubiquitous physiological process for Gram-negative bacteria. Despite their characterized biological roles, especially for pathogens, very little is known about their importance for the originating organism as well as regulation and mechanism of production. Only when we have established their biogenesis can we fully uncover their roles in pathogenesis and bacterial physiology. The overall goal of this research was to characterize bacterial mutants which display altered vesiculation phenotypes using genetic and biochemical techniques, and thereby begin to elucidate the mechanism of vesicle production and regulation. One part of this work elucidated a synthetic genetic growth defect for a strain with reduced OMV production (ΔnlpA, inner membrane lipoprotein with a minor role in methionine transport) and envelope stress (ΔdegP, dual function periplasmic chaperone/ protease responsible for managing proteinaceous waste). This research showed that the growth defect of ΔnlpAΔdegP correlated with reduced OMV production with respect to the hyprevesiculator ΔdegP and the accumulation of protein in the periplasm and DegP substrates in the lumen of OMVs. We further demonstrated that OMVs do not solely act as a stress response pathway to rid the periplasm of otherwise damaging misfolded protein but also of accumulated peptidoglycan (PG) fragments and lipopolysaccharide (LPS), elucidating OMVs as a general stress response pathway critical for bacterial well-being. The second part of this work, focused on the role of PG structure, turnover and covalent crosslinks to the OM in vesiculation. We established a direct link between PG degradation and vesiculation: Mutations in the OM lipoprotein nlpI had been previously established as a very strong hypervesiculation phenotype. In the literature NlpI had been associated with another OM lipoprotein, Spr that was recently identified as a PG hydrolase. The data presented here suggest that NlpI acts as a negative regulator of Spr and that the ΔnlpI hypervesiculation phenotype is a result of rampantly degraded PG by Spr. Additionally, we found that changes in PG structure and turnover correlate with altered vesiculation levels, as well as non-canonical D-amino acids, which are secreted by numerous bacteria on the onset of stationary phase, being a natural factor to increase OMV production. Furthermore, we discovered an inverse relationship between the concentration of Lpp-mediated, covalent crosslinks and the level of OMV production under conditions of modulated PG metabolism and structure. In contrast, situations that lead to periplasmic accumulation (protein, PG fragments, and LPS) and consequent hypervesiculation the overall OM-PG crosslink concentration appears to be unchanged. Form this work, we conclude that multiple pathways lead to OMV production: Lpp concentration-dependent and bulk driven, Lpp concentration-independent.

THE ART SONG OF SOUTH AMERICA: AN EXPLORATION THROUGH PERFORMANCE

The repertoire included in this dissertation was presented over the course of three recitals, The Songs of Argentina, The Songs of Brazil, Chile and Venezuela, and The Songs of Perú and Colombia. Each recital was supplemented by written program notes and English translations of the Spanish, Portuguese and Quechua texts. The selections presented in this study was chosen in an effort to pair the works of internationally renowned composers like Argentine composers Alberto Ginastera and Carlos Guastavino, and Brazilian composer Heitor Villa-Lobos, with those of lesser-known composers, including Venezuelan composer Juan Bautista Plaza, Peruvian composers Edgar Valcárcel, Theodoro Valcárcel, and Rosa Mercedes Ayarza de Morales, and Colombian composer Jaime Léon. Each composer represents a milestone in the development of art song composition in South America. All three recitals were recorded and are available on compact discs in the Digital Repository at the University of Maryland (DRUM). This dissertation was completed in May, 2011.