Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS

The hydrophobin EAS from the fungus Neurospora crassa forms functional amyloid fibrils called rodlets that facilitate spore formation and dispersal. Self-assembly of EAS into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers. We have used site-directed mutagenesis and peptide experiments to identify the region of EAS that drives intermolecular association and formation of the cross-β rodlet structure. Transplanting this region into a nonamyloidogenic hydrophobin enables it to form rodlets. We have also determined the structure and dynamics of an EAS variant with reduced rodlet-forming ability. Taken together, these data allow us to pinpoint the conformational changes that take place when hydrophobins self-assemble at an interface and to propose a model for the amphipathic EAS rodlet structure.

Is maternal nutrition knowledge more strongly associated with the diets of mothers or their school-aged children?

Objective Maternal nutrition knowledge has frequently been identified as an important target for nutrition promotion interventions. The aim of the present study was to investigate whether maternal nutrition knowledge is more strongly associated with the mother's own diet or that of her child.

Design Cross-sectional multivariate linear regression with interactions analyses of survey data.

Setting Socio-economically disadvantaged neighbourhoods in Victoria, Australia.

Subjects Five hundred and twenty-three mothers and their children who participated in the Resilience for Eating and Physical Activity Despite Inequality (READI) study, a cross-sectional survey study conducted in 2009 among women and their children residing in socio-economically disadvantaged neighbourhoods.

Results In adjusted models, for three (vegetable, chocolate/lollies and soft drink consumption) out of the seven dietary outcomes assessed, there was a significant association between maternal nutrition knowledge and maternal diet, whereas for the children's diets none of the seven outcomes were associated with maternal nutrition knowledge. Statistical comparison of regression coefficients showed no difference between the maternal nutrition knowledge–maternal diet association and the maternal nutrition knowledge–child diet association.

Conclusions Promoting maternal nutrition knowledge may represent an important avenue for improving diet in mothers from socio-economically disadvantaged neighbourhoods, but more information is needed on how and when this knowledge is translated to benefits for their children's diet.

Multi-target tracking via space transformations using a single frequency continuous wave radar

This paper investigates the location and velocity estimation problem involving multiple targets using the phase difference and frequency shift of the returned Doppler modulated signal. The minimal receiver configuration that addresses the data association and missing information problem is presented for the case of linear arrays. Non-linearly modeled Doppler radar measurements are used to obtain an accurate estimate of the target dynamics progressively in a linear framework utilizing a recently developed robust state estimation approach.

Visualizing the core-periphery distinction in theory domains

As specific parts of a theory are refined over time, the aggregated set of variables and associations of multiple theory instances provide the identity of a theory domain. This research applies a meta-theoretical analysis to the problem of theory identity and the core-periphery distinction. The theoretico-empirical network for quantitative publications over a 20 year span of two top Information Systems journals is analysed and visualized to illustrate these aspects of theory. The analysis provides insight into the density of research in specific theory domains, the verisimilitude and explanatory ubiquity of core versus peripheral postulates, and suggests opportunities for increasing explanatory depth and integration in select theory domains.

Need for a cohesive television policy in India

The Indian television industry has been dramatically transformed since 1991 when foreign television channels such as STAR TV and others began beaming their programs into Indian households from foreign soil. The impact of the exponential growth in television channelsi, television viewers and the television software industry in India between 1991 and 2006 has been well documented (Rodrigues, 1998, 2005). This paper analyses whether the Indian government’s television policy during the past decade and a half adequately met the challenge of the entry of private and foreign channels into Indian homes. The paper also makes a set of recommendations to the Government of India with regards to its television policy so that this popular medium can achieve its potential as a catalyst for social change in India (NAMEDIA, 1986).

Risk factors for recurrent Mycobacterium ulcerans disease after exclusive surgical treatment in an Australian cohort

Objective: To describe risk factors for recurrence after exclusive surgical treatment of Mycobacterium ulcerans infection. Design, setting and participants: Prospective observational cohort study of all M. ulcerans cases managed with surgery alone at Barwon Health, a tertiary referral hospital, from 1 January 1998 to 31 December 2011. A random-effects Poisson regression model was used to assess rates and associations of treatment failure. Main outcome measures: Rates of treatment failure and rate ratios (RRs) for factors associated with treatment failure. Results: Of 192 patients with M. ulcerans infection, 50 (26%) had exclusive surgical treatment. Median age was 65.0 years (interquartile range [IQR], 45.5-77.7 years), and median duration of symptoms was 46 days (IQR, 26-90 days). There were 20 recurrences in 16 patients. For first lesions, the recurrence incidence rate was 41.8 (95% CI, 25.6-68.2) per 100 person-years, and median time to recurrence was 50 days (IQR, 30-171 days). Recurrence occurred ≤ 3 cm from the original lesion in 13 cases, and >3 cm in nine. On univariable analysis, age ≥60 years (RR 13.84; 95% CI, 2.21-86.68; P< 0.01), distal lesions (RR, 20.43; 95% CI, 1.97-212.22; P<0.01), positive histological margins (RR, 21.02; 95% CI, 5.51-80.26; P< 0.001), immunosuppression (RR, 17.97; 95% CI, 4.17-77.47; P <0.01) and duration of symptoms >75 days (RR, 10.13; 95% CI, 1.76-58.23; P =0.02) were associated with treatment failure. On multivariable analysis, positive margins (RR, 7.72; 95% CI, 2.71-22.01; P<0.001) and immunosuppression (RR, 6.45; 95% CI, 2.42-17.20; P =0.01) remained associated with treatment failure. Conclusions: Recurrence rates after exclusive surgical treatment of M. ulcerans disease in an Australian cohort are high, with increased rates associated with immunosuppression or positive histological margins.

The limitations of front-end loading in undergraduate university programs

This paper shows how Mead’s theory of emergence can prove explanatory in how the theory-practice gap is co-created and sustained in front-end loading university programs. Taking teacher education as an exemplar, we argue that the trainee teacher encounters different and oft-times conflicting environmental, social and cultural conditions in the two “fields of interaction” of the training program, namely, on-campus work and in-school experience. The argument draws on interview and focus group data collected via a study of first-year graduate teachers of an Australian teacher education program. We conclude that role taking and self-regulated behaviour within the two environmental fields of interaction in front-end loading programs inhibit the trainee professional from exercising the power of agency to implement theory learned at university in practice in the workplace. Further, we propose that Mead’s theory of emergence proves effective in explaining a major limitation of front-end-loaded university programs.

Liberalism

Liberalism as a theory about politics and society supports freedoms of belief, inquiry, expression, action, association, and elections. In liberalism, freedom coalesces with value commitments to equality, individualism, toleration, pluralism, and rationality. These commitments have interacted with science and technology in various ways.

Food insecurity among university students in Victoria: A pilot study

Aims: Susceptibility to food insecurity can vary over a life course; however, a potential period of particular vulnerability is while studying at a tertiary institution. This pilot study aimed to assess the prevalence, severity and potential determinants of food insecurity among tertiary students attending a Victorian-based institution. Methods: The present study employed a cross-sectional design, involving use of a self-reported questionnaire. The survey, conducted in 2012, was administered to a sample of 124 Deakin University students and contains measures of food insecurity status, demographics and other potential explanatory factors. Descriptive and regression analysis was undertaken to investigate the prevalence of food insecurity and associations with factors that may support or hinder a student's ability to procure food, such as living arrangements, income and knowledge of support services. Results: Food insecurity without hunger was reported by 18% of Deakin University students, while an additional 30% reported experiencing the more severe form of food insecurity (with hunger). A lower odds of being food insecure was reported among students living with their family (without hunger OR 0.35; 95% CI 0.12-0.99; with hunger OR 0.29; 95% CI 0.12-0.70), while a higher odds was found among those receiving government support (with hunger OR 2.52; 95% CI 1.05-6.04). Conclusions: The reported prevalence of food insecurity among the tertiary student sample was greater than the general Australian population, suggesting they are a vulnerable group. This may be attributable to financial pressures faced when students are not living with their parents.

Interview with Dr Ray Anere (d. 2015)

The late Dr Ray Anere was a Papua New Guinean who studied in Australia at the Australian National University in 1982 - 1985. He was awarded an Australian International Development Assistance Bureau (AIDAB) scholarship and completed a Master degree in Arts. He later completed a PhD at Claremont University in California, USA under a Fulbright Scholarship. Dr Anere was a Senior Research Fellow at the National Research Institute in PNG and maintained strong connections with Australia and with the USA. Dr Anere was a member of the PNG USA Alumni Association and the PNG Australia Alumni Association. Dr Anere passed away in April 2015. The interview was conducted in English on 17 December 2014 by Dr Musawe Sinebare and Mr Gande James, both of Pacific Adventist University. This set comprises: an interview recording, a timed summary and a photograph.

Everything that matters is silvery white

When Jared Diamond asked acclaimed evolutionary biologist Ernst Mayr why Aristotle didn’t come up with the theory of evolution, Mays answered frage stellen or ‘a way of asking questions’ (ABC 2013). The idea that a particular way-of-asking might generate a particular way-of-knowing is applicable to the practice of creative writing. Modjeska unpacks the concept of ‘temporising’ (2002: 75), inviting us to consider the generative possibilities of the temporising space – as an imaginative space for writers – a way of asking questions.Research contributionThis work enacts the concept of temporising at the level of form and content, interrogating the connection between language and imagery, and the work of association and similarity and, following Aristotle, recognises the temporising space as a metaphorical playground. This method of asking questions involves alogical processes of association: supporting Freud’s ‘reciprocal relations’ between dissimilars (1900: 404) and Froeschels’ observation that ‘the subconscious [mind] considers similarity identical with identity’ (qtd. in Mavromatis 1987: 178).Research significanceThis work uses Modjeska’s analysis, and theories of subconscious processes of association, to enact an inquiry in the performative narrative space of the short story. It has been longlisted for the Australian Book Review’s Elizabeth Jolley Prize (2014) and the Séan Ó Faoláin International Short Story Competition (Ireland) (2015), and was also a finalist in the Glimmer Train International Fiction Open Contest (USA) (2015).

Study protocol: the registrar clinical encounters in training (ReCEnT) study

Background
Patient encounters are the core learning activity of Australian general practice (family practice) training. Exposure to patient demographics and presentations may vary from one general practice registrar (vocational trainee) to another. This can affect comprehensiveness of training. Currently, there is no mechanism to systematically capture the content of GP registrar consultations. The aim of the Registrar Clinical Encounters in Training (ReCEnT) study is to document longitudinally the nature and associations of consultation-based clinical and educational experiences of general practice registrars.
Methods/design
This is an ongoing prospective multi-site cohort study of general practice registrars’ consultations, entailing paper-based recording of consultation data. The study setting is general practices affiliated with three geographically-based Australian general practice regional training providers. Registrars record details of 60 consecutive consultations. Data collected includes registrar demographics, details of the consultation, patient demographics, reasons for encounter and problems managed. Problems managed are coded with the International Classification of Primary Care (second edition) classification system. Additionally, registrars record educational factors related to the encounter. The study will follow the clinical exposure of each registrar six-monthly over the 18 months to two years (full-time equivalent) of their general practice training program.
Conclusions
The study will provide data on a range of factors (patient, registrar and consultation factors). This data will be used to inform a range of educational decisions as well as being used to answer educational research questions. We plan to use ReCEnT as a formative assessment tool for registrars and help identify and address educational needs. The study will facilitate program evaluation by the participating training providers and thus improve articulation of educational programs with practice experience. From the research point of view it will address an evidence gap – the in-practice clinical and educational experience of general practice trainees, determinants of these experiences, and the determinants of registrars’ patterns of practice (for example, prescribing practice) over the course of their training.

The use of mixed methods in drug discovery: integrating qualitative methods into clinical trials

Contemporary methods in clinical trials are pivoted around hypothesis confirmation, not generation. This is a problem for new drug discovery, since the pharmacokinetic or receptor profile of most novel agents do not link to pathophysiology, which is very poorly understood. Therefore, it is difficult to impute the therapeutic potential of a candidate agent. Most psychotropic agents were discovered serendipitously, either through careful clinical observation or by researchers finding unexpected associations in datasets. Methods that increase the ability to detect latent signals in data are needed. These include mixed methods that incorporate qualitative methods into randomized controlled trials.

This chapter proposes a methodology for the integration of mixed methods in clinical trials, fusing qualitative and quantitative methods, and presents an exemplar using this approach.

Mixed methods show potential for signal detection, hypothesis generation, and associations that may be otherwise undetected in traditional clinical trials.

Personality disorders in the community

Just under half of all people with psychiatric disorders, have a co-existing chronic physical illness. However, less attention has been paid the physical health outcomes of
individuals living with these disorders in the general population, or their
treatment seeking behaviors. In absence of these data, we do know those living
with PD encounter disability and suffer significantly. The aims of this thesis,
were to investigate the prevalence of PDs, and associations with physical
health comorbidities, and health service utilization, in population-based
samples (≥20 years), from Australia, and the United States (US).

Ela é carioca: um estudo da imagem da cidade do Rio de Janeiro sob o ponto de vista de cidadãos não-cariocas

The study it was considered to carry through an analysis of the city of Rio de Janeiro using the point of view of not Carioca citizens - in this case Baianos and Paulistas. The optics chosen for the analysis was the image, that is the resultant of aspects such as: mental ideas, feelings, emotions, attitudes, thoughts, cognitions, expectations, representations, perceptions, certainties and associations. A research with qualitative focus was carried through, of exploratory character, with not Carioca individuals, Baianos and Paulistas, with and without experience in Rio de Janeiro. The results point the main reason of the visit - or not - to Rio de Janeiro, the symbol of the city, the perception concerning its image and about its inhabitant - the Carioca.