Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer

BACKGROUND The immune contexture predicts prognosis in human colorectal cancer (CRC). Whereas tumour-infiltrating CD8+ T cells and myeloid CD16+ myeloperoxidase (MPO)+ cells are associated with favourable clinical outcome, interleukin (IL)-17-producing cells have been reported to correlate with severe prognosis. However, their phenotypes and functions continue to be debated. OBJECTIVE To investigate clinical relevance, phenotypes and functional features of CRC-infiltrating, IL-17-producing cells. METHODS IL-17 staining was performed by immunohistochemistry on a tissue microarray including 1148 CRCs. Phenotypes of IL-17-producing cells were evaluated by flow cytometry on cell suspensions obtained by enzymatic digestion of clinical specimens. Functions of CRC-isolated, IL-17-producing cells were assessed by in vitro and in vivo experiments. RESULTS IL-17+ infiltrates were not themselves predictive of an unfavourable clinical outcome, but correlated with infiltration by CD8+ T cells and CD16+ MPO+ neutrophils. Ex vivo analysis showed that tumour-infiltrating IL-17+ cells mostly consist of CD4+ T helper 17 (Th17) cells with multifaceted properties. Indeed, owing to IL-17 secretion, CRC-derived Th17 triggered the release of protumorigenic factors by tumour and tumour-associated stroma. However, on the other hand, they favoured recruitment of beneficial neutrophils through IL-8 secretion and, most importantly, they drove highly cytotoxic CCR5+CCR6+CD8+ T cells into tumour tissue, through CCL5 and CCL20 release. Consistent with these findings, the presence of intraepithelial, but not of stromal Th17 cells, positively correlated with improved survival. CONCLUSIONS Our study shows the dual role played by tumour-infiltrating Th17 in CRC, thus advising caution when developing new IL-17/Th17 targeted treatments.

Detection efficiency of microchannel plates for e(-) and pi(-) in the momentum range from 17.5 to 345 MeV/c

High-energy e(-) and pi(-) were measured by the multichannel plate (MCP) detector at the PiM1 beam line of the High Intensity Proton Accelerator Facilities located at the Paul Scherrer Institute, Villigen, Switzerland. The measurements provide the absolute detection efficiencies for these particles: 5.8% +/- 0.5% for electrons in the beam momenta range 17.5-300 MeV/c and 6.0% +/- 1.3% for pions in the beam momenta range 172-345 MeV/c. The pulse height distribution determined from the measurements is close to an exponential function with negative exponent, indicating that the particles penetrated the MCP material before producing the signal somewhere inside the channel. Low charge extraction and nominal gains of the MCP detector observed in this study are consistent with the proposed mechanism of the signal formation by penetrating radiation. A very similar MCP ion detector will be used in the Neutral Ion Mass (NIM) spectrometer designed for the JUICE mission of European Space Agency (ESA) to the Jupiter system, to perform measurements of the chemical composition of the Galilean moon exospheres. The detection efficiency for penetrating radiation determined in the present studies is important for the optimisation of the radiation shielding of the NIM detector against the high-rate and high-energy electrons trapped in Jupiter's magnetic field. Furthermore, the current studies indicate that MCP detectors can be useful to measure high-energy particle beams at high temporal resolution. (C) 2015 AIP Publishing LLC.

Na 1 Nachlass Max Horkheimer, 16 - Korrespondenzen u.a. mit Gerhart Jacoby Gordon (p. I 8, 202-379)

2 Briefe von A. Gandon an Max Horkheimer, Februrar 1936; 1 Brief von Max Horkheimer an Lloyd K. Garrison, 25.03.1941; 4 Briefe zwischen Moritz Geiger und Max Horkheimer, 01.12.1935, 1935; 1 Lebenslauf von Alvin Johnsson an Friedrich Pollock; 1 Brief von Alvon Johnson an Friedrich Pollock, 39.09.1940; 1 Brief von Max Horkheimer an Harald Genssler, 04.09.1949; 1 Brief von der George Washington University Washington an Max Horkheimer, 01.03.1939; 2 Briefe von Wolfgang Gerloff an Max Horkheimer, 1934, 1939; 2 Briefe zwsichen Hans Gerth und Max Horkheimer, 28.10.1937, 16.11.1937; 1 Brief von M. Getzer anMax Horkheimer, 04.05.1934; 12 Briefe zwsichen Edgar V. M. Gilbert und Max Horkheimer, 1935-1940; 1 Brief von der Gillespie, Kinsports & Bears Travel Agency New York an Max Horkheimer, 16.04.1935; 1 Entwurf von Max Horkheimer an Morris Ginsberg, Dezember 1935; 19 Briefe zwsichen Morris Ginsberg, Ethel Ginsberg und Max Horkheimer, 1935-1938; 2 Briefe zwischen Robert Morrison MacIver und Max Horkheimer, 18.08.1937, 16.08.1937; 1 Brief von H. Girsberger an Max Horkheimer, 17.08.1938; 1 Brief von Max Horkheimer an Glass, 24.12.1940; 1 Brief von der Glidden Buick Corporation New York an Max Horkheimer, 05.06.1940; 1 Heiratsanzeige von Vera Gold; 4 Briefe zwischen Oskar Goldberg und Max Horkheimer, 1941, 27.08.1941; 10 Briefe zwischen Hans Goldmann und Max Horkheimer, 1934-1937; 14 Briefe zwischen Alfons Goldschmidt und Max Horkheimer, 1936-1938; 7 Briefe zwsichen dem Greater New York Coordinating Committee for German Refugees, New York und Max Horkheimer, 1937-1939; 1 Brief von Max Horkheimer an Simon Guggenheim, 24.01.1938; 3 Briefe zwischen Aron Goldschmidt und Max Horkheimer, 02.02.1939, Mai 1942; 2 Briefe zwischen Berta Goldschmidt und Max Horkheimer, 14.01.1941, 25.02.1941; 4 Briefe von Emma Goldschmidt an Juliette Favez, 1938-1940; 5 Briefe zwischen Emma Goldschmidt und Max Horkheimer, 1938-1940; 2 Briefe zwischen Ernst L. Goldschmidt und Max Horkheimer, 08.07.1937, 18.06.1937; 1 Brief von Thea Goldschmidt an Max Horkheimer, 16.04.1935; 14 Briefe zwischen Kurt Goldstein und Max Horkheimer, 1934-1941; 19 Briefe zwsichen Gerhart Jacoby Gordon und Max Horkheimer, 1934-1937;

Na 1 Nachlass Max Horkheimer, 34 - Korrespondenzen u.a. mit Ludwig Marcuse und Henryk Grossmann (p. I 17, 255-472)

1 Brief von Eleanor Wilson MacAdoo an Max Horkheimer, 04.09.1942; 1 Brief von Walter J. Mahoney an Max Horkheimer, 27.03.1941; 6 Briefe zwischen Josef Maier und Max Horkheimer, 1935, 1936; 8 Briefe und 2 Beilagen zwischen Kurt Mandelbaum und Max Horkheimer, 1935, 1936; 1 Brief von Ernest Fred Manfred an Max Horkheimer, 10.07.1948; 1 Brief von Gertrud Marcuse an Max Horkheimer, 31.03.1937; 52 Brief und Beilage zwischen Sascha Marcuse, Ludwig Marcuse und Max Horkheimer, 1936-1943; 1 Brief von Juliette Favez an Sascha und Ludwig Marcuse, 09.09.1937; 2 Briefe von Max Horkheimer an Hendrik W. van Loon, 1940, 1941; 1 Brief von Bruno Frank an John Simon Guggenheim Memorial Foundation New York, 03.12.1940; 3 Briefe zwischen Paul Klapper und Max Horkheimer, 30.08.1939, 1939; 1 Brief von Max Horkheimer an Collector of Customs New York, 04.04.1939; 3 Briefe zwischen Paul Marcuse und Max Horkheimer, 06.06.1939, 1939; 1 brief von Friedrich Pollock an Leon C. Marshall, 05.05.1941; 1 Brief von Max Horkheimer an Marsten, 17.04.1939; 6 Briefe und 1 Beilage zwsichen A. Mansloff und Max Horkheimer, 1941; 1 Brief von Henrik Grossmann an Paul Mettick, 30.10.1935; 11 Briefe zwischen Paul Mattick und Max Horkheimer sowie Briefwechsel mit der John Simon Guggenheim Memorial Foundation, New York, 1935-1937; 4 Briefe zwischen der John Simon Guggenheim Memorial Foundation, New York und Max Horkheimer, 1937, 1938; 1 Brief von Henryk Grossmann an Paul Mattick, 30.10.1935; 2 Briefe zwischen Henryk Grossmann und Max Horkheimer, 15.10.1935, 02.02.1937; 1 Brief von Edith Mautner an Max Horkheimer, 15.06.1944; 2 Briefe zwischen Carl Mayer und Max Horkheimer, 23.10.1940, 22.11.1940; 5 Briefe zwischen Gustav Mayer und Max Horkheimer, 1940 sowie 1 Brief von Ulrich Mayer an Gumperz, 07.06.1940;

Bildnuß des Hoch und Wohlgebohrnen Herrn Herrn Herman Otto Grafens von Styrumb : ... welcher den 13. Februarii Anno 1678 von Neustadt bis auf Wienn 8 teutsche Meilen i[n]nerhalb 7 Viertelstunden ... geritten ...

Text in d. Platte graviert

[Eygentlicher Abriß der geschwinden Eroberung der Stadt Würtzburg] : [von Ihrer Königl. Majest. in Schweden, sampt dem vesten Schloß daselbsten ...] ; 1631, 8. October

Nebst Porträtmedaillon Gustav Adolfs II.

Fragm. lat. II 8 - Moralphilosophischer Text

Trägerband: Ms. Barth. 28; Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Hs. Rothschild 8° 63 - Hertzog Ernst von Bayern. Abschrift der Herzog Ernst-Handschrift D in Gotha

Vorbesitzer: Freiherrlich Carl von Rothschild'sche Bibliothek Frankfurt am Main (Bibliothek für Neuere Sprachen und Musik)

Ms. or. 17 - Gebete der heiligen Jungfrau Maria

Vorbesitzer: Eduard Rüppell;

Ms. var. oct. 8 No. 3a - Einige Grundriße von der Gemeinheit der Duchoborzen

Der Band ist nach der Katalogisierung neu gebunden worden.